Reposted by Sophie Binder
Happy to share our first foray into the world of AI-based #ProteinDesign. www.biorxiv.org/content/10.1...
Development of AI-designed protein binders for detection and targeting of cancer cell surface proteins
Artificial intelligence (AI)-based protein design opens new avenues for the rapid generation of new research tools and therapeutics, but experimental validation lags behind the computational design th...
www.biorxiv.org
May 18, 2025 at 5:06 PM
Happy to share our first foray into the world of AI-based #ProteinDesign. www.biorxiv.org/content/10.1...
Reposted by Sophie Binder
Out today @ Science: TIR signaling activates caspase-like immunity in bacteria
We report a new immune signaling molecule: N7-cADPR. Produced by phage-induced TIRs and activates a defensive bacterial caspase
Congrats Francois Rousset, Ilya Osterman and coauthors!
www.science.org/doi/10.1126/...
We report a new immune signaling molecule: N7-cADPR. Produced by phage-induced TIRs and activates a defensive bacterial caspase
Congrats Francois Rousset, Ilya Osterman and coauthors!
www.science.org/doi/10.1126/...
January 30, 2025 at 9:57 PM
Out today @ Science: TIR signaling activates caspase-like immunity in bacteria
We report a new immune signaling molecule: N7-cADPR. Produced by phage-induced TIRs and activates a defensive bacterial caspase
Congrats Francois Rousset, Ilya Osterman and coauthors!
www.science.org/doi/10.1126/...
We report a new immune signaling molecule: N7-cADPR. Produced by phage-induced TIRs and activates a defensive bacterial caspase
Congrats Francois Rousset, Ilya Osterman and coauthors!
www.science.org/doi/10.1126/...
Reposted by Sophie Binder
Substrate binding proteins and nanobodies - that’s protein biochemistry heaven. In our new publication we characterized a nanobody that allosterically inhibits the SBP VcSiaP.
Amazing job by @nschneberger.bsky.social and thanks to everyone involved! As always a great team effort!
rdcu.be/d1foN
Amazing job by @nschneberger.bsky.social and thanks to everyone involved! As always a great team effort!
rdcu.be/d1foN
Allosteric substrate release by a sialic acid TRAP transporter substrate binding protein
Communications Biology - Biophysical and structural characterization of the TRAP transporter SBP SiaP in complex with a nanobody provides insights into an allosteric mechanism of inhibition.
rdcu.be
November 24, 2024 at 2:44 PM
Substrate binding proteins and nanobodies - that’s protein biochemistry heaven. In our new publication we characterized a nanobody that allosterically inhibits the SBP VcSiaP.
Amazing job by @nschneberger.bsky.social and thanks to everyone involved! As always a great team effort!
rdcu.be/d1foN
Amazing job by @nschneberger.bsky.social and thanks to everyone involved! As always a great team effort!
rdcu.be/d1foN