🦠Reuben Shaw, cancer biologist who studies the connections between cancer and metabolism

🌿Joseph Nery, research assistant in Ecker's lab where he lends his expertise in single-cell genetic and epigenetic sequencing techniques and computational analyses

🧠Rusty Gage, neuroscientist who studies the plasticity, adaptability, and diversity of the brain

🧠Kay Tye, neuroscientist who studies the neural circuit basis of emotion and how it shapes social interaction, reward-seeking, and avoidance behaviors

🍎Christian Metallo, bioengineer who studies how our body metabolizes molecules like glucose, fats, and amino acids to generate the building blocks and energy we need to perform life-sustaining tasks

💤Satchin Panda, biologist and expert on the cellular and molecular basis of circadian rhythms

🌿Joseph Ecker, plant and molecular biologist who researches genomic and epigenomic regulation in plants and mammals.

🔬Ronald Evans, microbiologist and expert on the role of hormone receptors in reproduction, growth, and metabolism

The highly cited researchers include Salk scientists Joseph Ecker, Ronald Evans, Rusty Gage, Christian Metallo, Satchin Panda, Reuben Shaw, Kay Tye, and Joseph Nery.

Being a highly cited researcher shows how often others build on one’s work, highlighting its influence in advancing knowledge and guiding future discovery. At Salk, our discoveries often serve as a foundation for asking bigger questions that lead to bigger solutions to the world's challenges.

The researchers captured these important structural changes for the first time, creating novel 3D models of integrase in both roles. Now, scientists can connect the dots between integrase’s form and function to develop compounds that more precisely disrupt integrase and treat HIV.

One promising treatment avenue is disrupting HIV replication by impairing the function of integrase, a flexible protein that incorporates viral genetic material into the human host genome early in the HIV replication cycle, then alters its structure to help HIV again later in replication.

#HIV

The findings will help neuroscientists better understand and treat memory issues in mental disorders such as schizophrenia, traumatic brain injury (TBI), and post-traumatic stress disorder (PTSD).

Science is a shared fabric- each generation weaves its discoveries into the fabric of the next. This week's Nobel honors one vital thread in that tapestry. Here’s to the future our Salk immunologists are stitching together.

#Nobel2025 #Immunology #RegulatoryTcells #SalkScience #ScienceCantWait

🥜 Jamie Blum investigates oral tolerance—the immune system’s calm, noninflammatory response to most foods—opening possibilities for new ways to prevent or treat food allergies.

🤰 Deepshika Ramanan studies how maternal immunity during pregnancy and breastfeeding can shape a baby’s regulatory T cells and influence lifelong disease susceptibility.

🧵 Ye Zheng explores how regulatory T cells develop and function, identifying proteins that could be targeted to boost their protective role in autoimmune diseases.

At the Salk Institute, we’re continuing to unravel the intricate threads of immunity that these scientists first revealed. Our researchers are building on that legacy.