@sachin-sharma.bsky.social
• Inducible deletion of aCDase in HSCs promotes MMP-1-mediated collagen degradation and ECM remodeling, leading to fibrosis regression.
• Developed a novel small-molecule aCDase inhibitor, compound 5A, demonstrated efficacy in enhancing ECM degradation and resolving fibrosis in two mouse models.
• Developed a novel small-molecule aCDase inhibitor, compound 5A, demonstrated efficacy in enhancing ECM degradation and resolving fibrosis in two mouse models.
August 28, 2025 at 8:07 PM
• Inducible deletion of aCDase in HSCs promotes MMP-1-mediated collagen degradation and ECM remodeling, leading to fibrosis regression.
• Developed a novel small-molecule aCDase inhibitor, compound 5A, demonstrated efficacy in enhancing ECM degradation and resolving fibrosis in two mouse models.
• Developed a novel small-molecule aCDase inhibitor, compound 5A, demonstrated efficacy in enhancing ECM degradation and resolving fibrosis in two mouse models.
𝗞𝗲𝘆 𝗛𝗶𝗴𝗵𝗹𝗶𝗴𝗵𝘁𝘀:
• Stimulate HSCs to degrade the extracellular matrix (ECM) and promote fibrosis resolution.
• Uncover a key signaling mechanism, protein kinase Cα (PKCα) regulated AP1-MMP1 axis, which induces ECM breakdown.
• Stimulate HSCs to degrade the extracellular matrix (ECM) and promote fibrosis resolution.
• Uncover a key signaling mechanism, protein kinase Cα (PKCα) regulated AP1-MMP1 axis, which induces ECM breakdown.
August 28, 2025 at 8:07 PM
𝗞𝗲𝘆 𝗛𝗶𝗴𝗵𝗹𝗶𝗴𝗵𝘁𝘀:
• Stimulate HSCs to degrade the extracellular matrix (ECM) and promote fibrosis resolution.
• Uncover a key signaling mechanism, protein kinase Cα (PKCα) regulated AP1-MMP1 axis, which induces ECM breakdown.
• Stimulate HSCs to degrade the extracellular matrix (ECM) and promote fibrosis resolution.
• Uncover a key signaling mechanism, protein kinase Cα (PKCα) regulated AP1-MMP1 axis, which induces ECM breakdown.