As was often the case before our villains became cartoonish, Watson’s flaws were complex

This is their “gold standard” now.

A website for the MSCA project Waste2Drug

Societies should learn from this and speak up to support inclusion

A direct electroreductive functionalization of tropones employing aldehydes as alkylating agents is reported. This C(sp2)-H functionalization process leverages the mediation of electroactive nickel complexes, enabling a wide range of both native and substituted tropones (44 examples) to be alkylated selectively at the α-position in high yields (up to 90%). Combined electrochemical, spectroelectrochemical, and computational analyses disclosed the whole mechanistic pathway and revealed the key role played by reduced Ni complexes in activating the tropone core toward condensation with the aldehydes.