Extending nirmatrelvir–ritonavir treatment beyond 5 days resulted in a nominal improvement in the frequency of viral rebound and was generally well tolerated.

i.e: proportion of randomly assigned and dosed participants with sustained nasopharyngeal SARS-CoV-2 RNA concentrations below the lower limit of quantification (2·0 log10 copies per mL) from days 15 to 44.

Thank you Dr Yamey

We find that the closest-inferred ancestors of SARS-CoV-1 likely circulated in western China (Yunnan, Sichuan, or Guizhou), and that of SARS-CoV-2 in Yunnan, China, or Northern Laos, overlapping with contiguous karst and cave landscapes extending through these regions.

“We must actively challenge policies that seek to suppress knowledge, advocate for continued access to research funding, and support journals and institutions that prioritize evidence-based, apolitical dissemination of science. “