Rui Mu
@rui-mu.bsky.social
PhD student in Biomedical Informatics and Data Science program at Washington University school of Medicine
Reposted by Rui Mu
Exciting news! Our new paper is out in Neuron! We discovered how neurons drive brain tumor growth through aberrant glutamate–tyrosine kinase signaling, uncovering novel mechanisms that shape tumor progression. Grateful to our team & collaborators for making this breakthrough possible! 🧠✨
Aberrant coupling of glutamate and tyrosine kinase receptors enables neuronal control of brain-tumor growth
Anastasaki and colleagues establish a previously unknown glutamate growth dependency
in pediatric low-grade brain tumors (gliomas). Glioma cells hijack normal neuron-glial
molecular circuits present d...
www.cell.com
September 3, 2025 at 2:22 PM
Exciting news! Our new paper is out in Neuron! We discovered how neurons drive brain tumor growth through aberrant glutamate–tyrosine kinase signaling, uncovering novel mechanisms that shape tumor progression. Grateful to our team & collaborators for making this breakthrough possible! 🧠✨
Reposted by Rui Mu
We are so proud of Rasha and Rui's new paper! Their single cell reveals hidden diversity in CD8+ exhausted T cells across cancers, shedding light on why patients respond differently to immunotherapy and bringing us closer to more effective therapies. Don’t miss this exciting advance from our team!
Pan-cancer single cell transcriptomic clustering reveals heterogeneous CD8+ exhausted T cell populations with different immune checkpoint inhibitor responses
In most cancers, T lymphocytes comprise an essential cellular component of the non-neoplastic microenvironment, where they have the capacity to both suppress and support tumor growth. One specializ...
www.tandfonline.com
August 4, 2025 at 2:41 PM
We are so proud of Rasha and Rui's new paper! Their single cell reveals hidden diversity in CD8+ exhausted T cells across cancers, shedding light on why patients respond differently to immunotherapy and bringing us closer to more effective therapies. Don’t miss this exciting advance from our team!
Reposted by Rui Mu
Excited to share a new paper from @rashab.bsky.social on exhausted CD8 T cells and low grade brain tumors in #NF1.
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Human single cell RNA-sequencing reveals a targetable CD8+ exhausted T cell population that maintains mouse low-grade glioma growth
Nature Communications - With the emergence of immune checkpoint inhibitor therapies for cancer, the authors use single-cell sequencing to assess exhausted T cell content in human glioma samples and...
nam10.safelinks.protection.outlook.com
November 28, 2024 at 1:34 PM
Excited to share a new paper from @rashab.bsky.social on exhausted CD8 T cells and low grade brain tumors in #NF1.
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