Biocompatible chemistry merges chemo-catalytic reactions with cellular metabolism for sustainable small-molecule synthesis. Now a biocompatible Lossen rearrangement has been demonstrated to control ba...

Nature Reviews Molecular Cell Biology, Published online: 21 May 2025; doi:10.1038/s41580-025-00862-zIn this Tools of the Trade article, Abdallah (Gilbert lab) describes the development of direct analysis of ribosome targeting (DART), a tool designed to explore 5' UTR sequences for their potential to efficiently initiate translation.

Traditional mass spectrometry (MS)-based proteomics aims to detect and measure protein expression on a global scale and elucidate the link between protein function and phenotypic characteristics. Although advances in MS technology have significantly broadened the scope of detectable proteomes, these methodologies p

Biomacromolecules are delivered into cells using nanoparticles made of elastin and endosomal escape sequences.

Researchers couple AI and chemical know-how to create tools for cyclopropanation and silylation reactions

The biosynthesis of bioorthogonal chemical handles for precise protein labeling remains a significant challenge. In this issue of Chem, Thomas Huber and colleagues report the successful biosynthesis of nitrile-containing amino acids and their site-specific incorporation into proteins, enabling efficient protein conjugation and fluorogenic labeling.

Messenger RNA (mRNA) vaccines hold promise for creating new and improved immunizations; however, their delivery is challenging in terms of compliance, reactogenicity, cost and scalability. In response...

Spatial proteomics is helping biologists to uncover how cells work by mapping where proteins operate.

Mammalian cells present RNA-binding proteins on the cell surface that form clustered domains containing glycoRNAs.

Millions of ribosomes are packed within mammalian cells, yet we lack tools to visualize them in toto and characterize their subcellular composition. In this study, we present ribosome expansion micros...

mRNA with engineered poly(A) tails produces prolonged higher levels of protein.

Biochemical characterization of 66 carbohydrate-active enzymes from the gut microorganism Akkermansia muciniphila reveals that these enzymes can break down a range of host glycans, including mucin, which they degrade to completion.

Cells have evolved mechanisms to distribute ~10 billion protein molecules to subcellular compartments where diverse proteins involved in shared functions must assemble. Here, we demonstrate that prote...