Roychoudhuri Lab
@roychoudhurilab.bsky.social
Professor of Cancer Immunology and Immunotherapy
University of Cambridge, UK
http://www.roychoudhurilab.org
University of Cambridge, UK
http://www.roychoudhurilab.org
Pinned
Thrilled to share new work led by @jieyang437.bsky.social in the lab published today in @Nature. We find that Aspirin prevents metastasis by releasing T cells from immune suppression by platelet TXA2. @Cambridge_Uni @CRUKCamCentre rdcu.be/eci1U
We're hiring! We are looking for a Research Assistant with protein biochemistry skills to develop novel protein-based immunotherapeutics targeting Treg cells in cancer. You'll join
@roychoudhurilab.bsky.social @campathology.bsky.social @crukcamcentre.bsky.social Apply: jobs.cam.ac.uk/job/53219/
@roychoudhurilab.bsky.social @campathology.bsky.social @crukcamcentre.bsky.social Apply: jobs.cam.ac.uk/job/53219/
November 10, 2025 at 7:40 AM
We're hiring! We are looking for a Research Assistant with protein biochemistry skills to develop novel protein-based immunotherapeutics targeting Treg cells in cancer. You'll join
@roychoudhurilab.bsky.social @campathology.bsky.social @crukcamcentre.bsky.social Apply: jobs.cam.ac.uk/job/53219/
@roychoudhurilab.bsky.social @campathology.bsky.social @crukcamcentre.bsky.social Apply: jobs.cam.ac.uk/job/53219/
Reposted by Roychoudhuri Lab
Interesting how companies and the financial world is racing to spend mindboggling amounts of money to build the infrastructure to train computers. But we are leaving the infrastructure to train and educate humans crumbling. The question is who will train who?
a man in a suit is holding a jacket and a cigarette .
ALT: a man in a suit is holding a jacket and a cigarette .
media.tenor.com
October 8, 2025 at 5:15 PM
Interesting how companies and the financial world is racing to spend mindboggling amounts of money to build the infrastructure to train computers. But we are leaving the infrastructure to train and educate humans crumbling. The question is who will train who?
A more consistently warm home, no damp on the walls in winter and much cheaper heating
Love seeing people embrace greener heating. what’s been the biggest benefit for your home so far?
October 9, 2025 at 5:43 AM
A more consistently warm home, no damp on the walls in winter and much cheaper heating
Wonderful to see the seminal discoveries of Shimon Sakaguchi, Mary E. Brunkow & Fred Ramsdell recognised with the Nobel Prize. From Sakaguchi’s discovery of Treg cells to the identification of Foxp3, their research opened a new chapter in immunology, viewed from the prism of dominant tolerance.
October 6, 2025 at 9:56 PM
Wonderful to see the seminal discoveries of Shimon Sakaguchi, Mary E. Brunkow & Fred Ramsdell recognised with the Nobel Prize. From Sakaguchi’s discovery of Treg cells to the identification of Foxp3, their research opened a new chapter in immunology, viewed from the prism of dominant tolerance.
Reposted by Roychoudhuri Lab
Now in #Science #Immunology: @griffithslab.bsky.social report that when #CD8 #TCells encounter their targets, #nucleus localizes to the #ImmuneSynapse (IS) & facilitates delivery of newly synthesized cytokines to the IS. They find nuclear polarization represents key step in #CTL -mediated killing!
Nuclear polarization to the immune synapse facilitates an early transcriptional burst
Cytotoxic T lymphocyte target recognition triggers rapid nuclear polarization to the immune synapse and an early transcriptional burst of cytokines.
www.science.org
September 19, 2025 at 8:54 PM
Now in #Science #Immunology: @griffithslab.bsky.social report that when #CD8 #TCells encounter their targets, #nucleus localizes to the #ImmuneSynapse (IS) & facilitates delivery of newly synthesized cytokines to the IS. They find nuclear polarization represents key step in #CTL -mediated killing!
The new #ALASCCA RCT shows that low-dose aspirin prevents metastatic recurrence by ~50% in patients with PI3K altered colorectal cancer #aspirin #metastasis #prevention
September 19, 2025 at 9:49 PM
The new #ALASCCA RCT shows that low-dose aspirin prevents metastatic recurrence by ~50% in patients with PI3K altered colorectal cancer #aspirin #metastasis #prevention
A fantastic 2 days in Lille thinking T cell therapy at CAR T Day - the 9th international symposium on CAR T cells cartday.org. Thanks to Suman Mitra for the invitation to share our new data
CAR T Day
International Symposium on CAR T Cells
cartday.org
September 12, 2025 at 7:51 AM
A fantastic 2 days in Lille thinking T cell therapy at CAR T Day - the 9th international symposium on CAR T cells cartday.org. Thanks to Suman Mitra for the invitation to share our new data
Cool to see so many #heatpumps being installed this year. We’ve had our heatpump at home now for 3 years and it’s been saving us money while providing more comfortable heating and reducing our estimated CO2e by 75-80%.
August 14, 2025 at 9:22 AM
Cool to see so many #heatpumps being installed this year. We’ve had our heatpump at home now for 3 years and it’s been saving us money while providing more comfortable heating and reducing our estimated CO2e by 75-80%.
Please sign: petition.parliament.uk/petitions/72...
Petition: Review all trade ties with Israel, suspend 2030 roadmap & impose trade sanctions
We call on the Government to review existing trade ties with Israel, suspend the 2030 Roadmap for UK-Israel bilateral relations and impose trade sanctions upon Israel.
petition.parliament.uk
August 7, 2025 at 9:24 AM
Please sign: petition.parliament.uk/petitions/72...
Please sign this Parliamentary petition calling for comprehensive trade sanctions on Israel - the limited sanctions on specific members of the Israeli Government by the UK do not go far enough: petition.parliament.uk/petitions/72...
Petition: Review all trade ties with Israel, suspend 2030 roadmap & impose trade sanctions
We call on the Government to review existing trade ties with Israel, suspend the 2030 Roadmap for UK-Israel bilateral relations and impose trade sanctions upon Israel.
petition.parliament.uk
August 5, 2025 at 6:09 PM
Please sign this Parliamentary petition calling for comprehensive trade sanctions on Israel - the limited sanctions on specific members of the Israeli Government by the UK do not go far enough: petition.parliament.uk/petitions/72...
July 31, 2025 at 8:35 AM
The limited set of sanctions the UK has placed on specific individuals in Israel is not enough. Comprehensive sanctions needed to pressure the Israeli govt to reverse course in #Gaza. Please sign this petition to Parliament: #StopIsraelNow: chng.it/tsH8ZSJfRH via
@UKChange
@UKChange
Sign the Petition
#StopIsraelNow: Urgent Call for Economic Sanctions and Arms Embargo on Israel by the UK
chng.it
May 21, 2025 at 12:03 PM
The limited set of sanctions the UK has placed on specific individuals in Israel is not enough. Comprehensive sanctions needed to pressure the Israeli govt to reverse course in #Gaza. Please sign this petition to Parliament: #StopIsraelNow: chng.it/tsH8ZSJfRH via
@UKChange
@UKChange
Reposted by Roychoudhuri Lab
Please sign this urgent petition to Parliament: #StopIsraelNow: Urgent Call for Economic Sanctions and Arms Embargo on Israel by the UK chng.it/tsH8ZSJfRH via
@ukchange.bsky.social
@ukchange.bsky.social
Sign the Petition
#StopIsraelNow: Urgent Call for Economic Sanctions and Arms Embargo on Israel by the UK
chng.it
May 20, 2025 at 12:23 PM
Please sign this urgent petition to Parliament: #StopIsraelNow: Urgent Call for Economic Sanctions and Arms Embargo on Israel by the UK chng.it/tsH8ZSJfRH via
@ukchange.bsky.social
@ukchange.bsky.social
Please sign this urgent petition to Parliament: #StopIsraelNow: Urgent Call for Economic Sanctions and Arms Embargo on Israel by the UK chng.it/tsH8ZSJfRH via
@ukchange.bsky.social
@ukchange.bsky.social
Sign the Petition
#StopIsraelNow: Urgent Call for Economic Sanctions and Arms Embargo on Israel by the UK
chng.it
May 20, 2025 at 12:23 PM
Please sign this urgent petition to Parliament: #StopIsraelNow: Urgent Call for Economic Sanctions and Arms Embargo on Israel by the UK chng.it/tsH8ZSJfRH via
@ukchange.bsky.social
@ukchange.bsky.social
Reposted by Roychoudhuri Lab
Many wonders of aspirin 👍
Research Highlight of our recent paper by @jieyang437.bsky.social on Aspirin and cancer metastasis in Nature Reviews Immunology. Thanks to Yvonne Bordon for a crystal clear account of the experimental findings www.nature.com/articles/s41...
Aspirin helps T cells to stop cancer spread - Nature Reviews Immunology
Drugs like aspirin can enhance the anti-metastatic activity of T cells by blocking a platelet-mediated pathway of suppression.
www.nature.com
March 25, 2025 at 8:20 PM
Many wonders of aspirin 👍
Reposted by Roychoudhuri Lab
T-cell-derived IFN-γ suppresses T follicular helper cell differentiation and antibody responses
www.embopress.org/doi/full/10....
@iannaconelab.bsky.social
www.embopress.org/doi/full/10....
@iannaconelab.bsky.social
April 3, 2025 at 1:07 AM
T-cell-derived IFN-γ suppresses T follicular helper cell differentiation and antibody responses
www.embopress.org/doi/full/10....
@iannaconelab.bsky.social
www.embopress.org/doi/full/10....
@iannaconelab.bsky.social
Reposted by Roychoudhuri Lab
Really enjoyed discussing our recent findings and thoughts on cancer immunity with Nick Jikomes of the Mind and Matter podcast mindandmatter.substack.com/p/can-aspiri...
@campathology.bsky.social @crukcamcentre.bsky.social
@campathology.bsky.social @crukcamcentre.bsky.social
Can Aspirin Prevent Cancer Metastasis? | Rahul Roychoudhuri | 216
Download, watch, read, or listen to this podcast conversation.
mindandmatter.substack.com
April 2, 2025 at 10:29 PM
Really enjoyed discussing our recent findings and thoughts on cancer immunity with Nick Jikomes of the Mind and Matter podcast mindandmatter.substack.com/p/can-aspiri...
@campathology.bsky.social @crukcamcentre.bsky.social
@campathology.bsky.social @crukcamcentre.bsky.social
Really enjoyed discussing our recent findings and thoughts on cancer immunity with Nick Jikomes of the Mind and Matter podcast mindandmatter.substack.com/p/can-aspiri...
@campathology.bsky.social @crukcamcentre.bsky.social
@campathology.bsky.social @crukcamcentre.bsky.social
Can Aspirin Prevent Cancer Metastasis? | Rahul Roychoudhuri | 216
Download, watch, read, or listen to this podcast conversation.
mindandmatter.substack.com
April 2, 2025 at 10:29 PM
Really enjoyed discussing our recent findings and thoughts on cancer immunity with Nick Jikomes of the Mind and Matter podcast mindandmatter.substack.com/p/can-aspiri...
@campathology.bsky.social @crukcamcentre.bsky.social
@campathology.bsky.social @crukcamcentre.bsky.social
Reposted by Roychoudhuri Lab
Soluble CTLA-4 regulates immune homeostasis and promotes resolution of inflammation by suppressing type 1 but allowing type 2 immunity @cp-immunity.bsky.social
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
April 2, 2025 at 3:50 AM
Soluble CTLA-4 regulates immune homeostasis and promotes resolution of inflammation by suppressing type 1 but allowing type 2 immunity @cp-immunity.bsky.social
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
Research Highlight of our recent paper by @jieyang437.bsky.social on Aspirin and cancer metastasis in Nature Reviews Immunology. Thanks to Yvonne Bordon for a crystal clear account of the experimental findings www.nature.com/articles/s41...
Aspirin helps T cells to stop cancer spread - Nature Reviews Immunology
Drugs like aspirin can enhance the anti-metastatic activity of T cells by blocking a platelet-mediated pathway of suppression.
www.nature.com
March 25, 2025 at 1:34 PM
Research Highlight of our recent paper by @jieyang437.bsky.social on Aspirin and cancer metastasis in Nature Reviews Immunology. Thanks to Yvonne Bordon for a crystal clear account of the experimental findings www.nature.com/articles/s41...
New results from the ALASCCA prospective randomised controlled trial showing daily #aspirin reduces colorectal cancer recurrence by ~50% in patients with PIK3CA or related mutations. Findings extend benefits of aspirin beyond Lynch syndrome cancers to nearly 40% of CRCs ascopubs.org/doi/10.1200/...
Low-dose aspirin to reduce recurrence rate in colorectal cancer patients with PI3K pathway alterations: 3-year results from a randomized placebo-controlled trial.
LBA125Background: Colorectal cancer (CRC) affects 1.9 million individuals globally each year. Among
patients with stage II-III CRC, 20-40% develop metastatic disease. Aspirin lowers
the incidence of a...
ascopubs.org
March 25, 2025 at 12:35 PM
New results from the ALASCCA prospective randomised controlled trial showing daily #aspirin reduces colorectal cancer recurrence by ~50% in patients with PIK3CA or related mutations. Findings extend benefits of aspirin beyond Lynch syndrome cancers to nearly 40% of CRCs ascopubs.org/doi/10.1200/...
Reposted by Roychoudhuri Lab
Reactivation of CTLA4-expressing T cells Accelerates Resolution of Lung Fibrosis in a Humanized Mouse Model @jclinical-invest.bsky.social
www.jci.org/articles/vie...
www.jci.org/articles/vie...
March 18, 2025 at 6:04 PM
Reactivation of CTLA4-expressing T cells Accelerates Resolution of Lung Fibrosis in a Humanized Mouse Model @jclinical-invest.bsky.social
www.jci.org/articles/vie...
www.jci.org/articles/vie...
Imagine if all those who are silent about the terrible evil being committed in Gaza spoke up
www.theguardian.com/commentisfre...
www.theguardian.com/commentisfre...
Imagine if all those who are silent about the terrible evil being committed in Gaza spoke up | Owen Jones
No crime in history has been so well documented by its victims. And yet inaction and censorship reign, says Guardian columnist Owen Jones
www.theguardian.com
March 19, 2025 at 7:21 AM
Imagine if all those who are silent about the terrible evil being committed in Gaza spoke up
www.theguardian.com/commentisfre...
www.theguardian.com/commentisfre...
Thank you Jae!
Congratulations!
Thrilled to share new work led by @jieyang437.bsky.social in the lab published today in @Nature. We find that Aspirin prevents metastasis by releasing T cells from immune suppression by platelet TXA2. @Cambridge_Uni @CRUKCamCentre rdcu.be/eci1U
March 13, 2025 at 6:10 AM
Thank you Jae!
Reposted by Roychoudhuri Lab
Huge study in @nature.com by the @roychoudhurilab.bsky.social group
#Aspirin prevents metastasis by releasing T cells from immune suppression by platelet TXA2. This could potentially revolutionize cancer treatment and make it so much more accessible!
#Aspirin prevents metastasis by releasing T cells from immune suppression by platelet TXA2. This could potentially revolutionize cancer treatment and make it so much more accessible!
Aspirin prevents metastasis by limiting platelet TXA2 suppression of T cell immunity - Nature
Inhibition of cyclooxygenase 1 releases T cells from immunosuppression by platelet-derived thromboxane A2, thereby enhancing the immune response against metastasis.
www.nature.com
March 7, 2025 at 3:09 PM
Huge study in @nature.com by the @roychoudhurilab.bsky.social group
#Aspirin prevents metastasis by releasing T cells from immune suppression by platelet TXA2. This could potentially revolutionize cancer treatment and make it so much more accessible!
#Aspirin prevents metastasis by releasing T cells from immune suppression by platelet TXA2. This could potentially revolutionize cancer treatment and make it so much more accessible!