Matteo Ruggiu, PhD
@rnadoctor.bsky.social
Professor, Head of Laboratory of RNA Biology & Molecular Neuroscience, St. John's University, New York, USA. Humanist, Spearfisherman & Freediver. Views my own.
Question is: Who paid for the wedding? B/c if her parents paid, that gave them leverage. It doesn't make their behavior (dad was just as awful as mom) justifiable, but they likely felt they were entitled to do as they pleased. And she saw this coming miles away.
November 24, 2025 at 12:53 AM
Question is: Who paid for the wedding? B/c if her parents paid, that gave them leverage. It doesn't make their behavior (dad was just as awful as mom) justifiable, but they likely felt they were entitled to do as they pleased. And she saw this coming miles away.
#scientistswhocook: I used the bonito skin to make crispy oven baked fish skin chips.
#bonito
#palamita
#FishChips
#bonito
#palamita
#FishChips
November 17, 2025 at 2:48 PM
#scientistswhocook: I used the bonito skin to make crispy oven baked fish skin chips.
#bonito
#palamita
#FishChips
#bonito
#palamita
#FishChips
I gave q.e.d. a try this week. I'm impressed.
darth vader is wearing a helmet and holding a lightsaber in a dark room .
ALT: darth vader is wearing a helmet and holding a lightsaber in a dark room .
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November 13, 2025 at 8:26 PM
I gave q.e.d. a try this week. I'm impressed.
At least he is taking full responsibility for his actions, but yeah, FAFO.
November 4, 2025 at 2:39 PM
At least he is taking full responsibility for his actions, but yeah, FAFO.
One question: does the server use only text, or also figures? I imagine one uploads an entire manuscript, figures included, but I also imagine that the algorithm cannot critically evaluate figures, only the authors' interpretation of the figures/results. Is that the case?
October 17, 2025 at 12:19 AM
One question: does the server use only text, or also figures? I imagine one uploads an entire manuscript, figures included, but I also imagine that the algorithm cannot critically evaluate figures, only the authors' interpretation of the figures/results. Is that the case?
Wow!
a man with his mouth open making a surprised face
ALT: a man with his mouth open making a surprised face
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October 16, 2025 at 4:44 PM
Wow!
Wow! Does it work for grant proposals too? Asking for a friend.
a man in a blue striped shirt and tie is saying oh my god wow
ALT: a man in a blue striped shirt and tie is saying oh my god wow
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October 15, 2025 at 4:52 PM
Wow! Does it work for grant proposals too? Asking for a friend.
Finally, beautiful cover art created by @ella-maru.bsky.social. The image wasn't selected as image cover by JBC, but I love it.
October 14, 2025 at 2:53 PM
Finally, beautiful cover art created by @ella-maru.bsky.social. The image wasn't selected as image cover by JBC, but I love it.
Bonus: RNA editing of CaV1.3_43S also alters drug sensitivity—increasing responsiveness to DHP Ca²⁺ channel blockers.
⚡ Editing is not random—it can reshape both physiology and pharmacology.
#IonChannels #physiology #pharmacology #PrecisionMedicine
⚡ Editing is not random—it can reshape both physiology and pharmacology.
#IonChannels #physiology #pharmacology #PrecisionMedicine
October 14, 2025 at 2:49 PM
Bonus: RNA editing of CaV1.3_43S also alters drug sensitivity—increasing responsiveness to DHP Ca²⁺ channel blockers.
⚡ Editing is not random—it can reshape both physiology and pharmacology.
#IonChannels #physiology #pharmacology #PrecisionMedicine
⚡ Editing is not random—it can reshape both physiology and pharmacology.
#IonChannels #physiology #pharmacology #PrecisionMedicine
Why does this matter?
Neurons expressing CaV1.3_43S are at risk of Ca²⁺ toxicity, e.g. in Parkinson’s, Alzheimer’s, and spinal cord injury.
RNA editing acts as a neuroprotective brake by dampening excessive Ca²⁺ influx.
#Parkinsons #Alzheimers #SpinalCordInjury #NeuroProtective
Neurons expressing CaV1.3_43S are at risk of Ca²⁺ toxicity, e.g. in Parkinson’s, Alzheimer’s, and spinal cord injury.
RNA editing acts as a neuroprotective brake by dampening excessive Ca²⁺ influx.
#Parkinsons #Alzheimers #SpinalCordInjury #NeuroProtective
October 14, 2025 at 2:47 PM
Why does this matter?
Neurons expressing CaV1.3_43S are at risk of Ca²⁺ toxicity, e.g. in Parkinson’s, Alzheimer’s, and spinal cord injury.
RNA editing acts as a neuroprotective brake by dampening excessive Ca²⁺ influx.
#Parkinsons #Alzheimers #SpinalCordInjury #NeuroProtective
Neurons expressing CaV1.3_43S are at risk of Ca²⁺ toxicity, e.g. in Parkinson’s, Alzheimer’s, and spinal cord injury.
RNA editing acts as a neuroprotective brake by dampening excessive Ca²⁺ influx.
#Parkinsons #Alzheimers #SpinalCordInjury #NeuroProtective
Editing of CaV1.3_43S produces loss-of-function changes:
👉 ↓ current density
👉 ↑ activation threshold
👉 Depolarized current window
Together, this converts the “short” splice variants into “long-like” channels, reducing Ca²⁺ overload.
👉 ↓ current density
👉 ↑ activation threshold
👉 Depolarized current window
Together, this converts the “short” splice variants into “long-like” channels, reducing Ca²⁺ overload.
October 14, 2025 at 2:43 PM
Editing of CaV1.3_43S produces loss-of-function changes:
👉 ↓ current density
👉 ↑ activation threshold
👉 Depolarized current window
Together, this converts the “short” splice variants into “long-like” channels, reducing Ca²⁺ overload.
👉 ↓ current density
👉 ↑ activation threshold
👉 Depolarized current window
Together, this converts the “short” splice variants into “long-like” channels, reducing Ca²⁺ overload.
CaV1.3 has long (CaV1.3L) and short (CaV1.3_43S) splice variants.
👉 We found that the short variant undergoes ~3x more RNA editing at its IQ domain (a crucial #calmodulin binding site in the C-terminus) than the long form.
This creates multiple edited isoforms with distinct channel properties.
👉 We found that the short variant undergoes ~3x more RNA editing at its IQ domain (a crucial #calmodulin binding site in the C-terminus) than the long form.
This creates multiple edited isoforms with distinct channel properties.
October 14, 2025 at 2:41 PM
CaV1.3 has long (CaV1.3L) and short (CaV1.3_43S) splice variants.
👉 We found that the short variant undergoes ~3x more RNA editing at its IQ domain (a crucial #calmodulin binding site in the C-terminus) than the long form.
This creates multiple edited isoforms with distinct channel properties.
👉 We found that the short variant undergoes ~3x more RNA editing at its IQ domain (a crucial #calmodulin binding site in the C-terminus) than the long form.
This creates multiple edited isoforms with distinct channel properties.
We uncover an unexpected synergy between RNA editing & alternative splicing in the CaV1.3 calcium channel. This mechanism fine-tunes neuronal Ca²⁺ entry & may protect against excitotoxicity.
#IonChannels #CalciumChannel #CACNA1D #ExcitoToxicity
#IonChannels #CalciumChannel #CACNA1D #ExcitoToxicity
October 14, 2025 at 2:39 PM
We uncover an unexpected synergy between RNA editing & alternative splicing in the CaV1.3 calcium channel. This mechanism fine-tunes neuronal Ca²⁺ entry & may protect against excitotoxicity.
#IonChannels #CalciumChannel #CACNA1D #ExcitoToxicity
#IonChannels #CalciumChannel #CACNA1D #ExcitoToxicity
Makes $100k/year but can't afford $800/month rent...? Even with child support something doesn't add up.
a man in a blue suit and tie is looking at something
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October 9, 2025 at 2:42 PM
Makes $100k/year but can't afford $800/month rent...? Even with child support something doesn't add up.
Why did this man chose to be a father 4 times, when he clearly never wanted to be involved in taking care of his own kids?
October 9, 2025 at 2:15 PM
Why did this man chose to be a father 4 times, when he clearly never wanted to be involved in taking care of his own kids?
I listened to the article on the Nature podcast, Helen; Very timely. Too bad the scientifically unfounded claim that taking #acetaminophen #Tylenol during pregnancy is linked to autism came out just a few days later.
October 6, 2025 at 3:00 PM
I listened to the article on the Nature podcast, Helen; Very timely. Too bad the scientifically unfounded claim that taking #acetaminophen #Tylenol during pregnancy is linked to autism came out just a few days later.