Reinhard Hinterleitner
@rh-lab.bsky.social
Assistant Professor, Department of Immunology, University of Pittsburgh
Mucosal Immunology, Protists, Celiac disease, IBD
Mucosal Immunology, Protists, Celiac disease, IBD
Reposted by Reinhard Hinterleitner
Myeloid IL-1β and stress exert opposing control over colitis severity through the α₁-adrenergic-enterochromaffin axis, uncovering a neuro-immune-epithelial circuit that shapes intestinal inflammation @cp-immunity.bsky.social
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
November 3, 2025 at 11:01 PM
Myeloid IL-1β and stress exert opposing control over colitis severity through the α₁-adrenergic-enterochromaffin axis, uncovering a neuro-immune-epithelial circuit that shapes intestinal inflammation @cp-immunity.bsky.social
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
Reposted by Reinhard Hinterleitner
How did #TyphoidMary infect dozens of people with typhoid-causing Salmonella bacteria while remaining asymptomatic? New research in mice led by Dr. Blanda Di Luccia suggests that #Tregs play a role.
Learn more: tinyurl.com/28k78fw9
Learn more: tinyurl.com/28k78fw9
October 28, 2025 at 12:27 PM
How did #TyphoidMary infect dozens of people with typhoid-causing Salmonella bacteria while remaining asymptomatic? New research in mice led by Dr. Blanda Di Luccia suggests that #Tregs play a role.
Learn more: tinyurl.com/28k78fw9
Learn more: tinyurl.com/28k78fw9
Reposted by Reinhard Hinterleitner
A very warm welcome to Dr. Blanda Di Luccia, who joined the department this month as a Research Assistant Professor! Her research focuses on understanding host-microbe interactions in the gut and how the immune system maintains tolerance during chronic infection. Learn more: bit.ly/3WXgr2V
October 27, 2025 at 1:05 PM
A very warm welcome to Dr. Blanda Di Luccia, who joined the department this month as a Research Assistant Professor! Her research focuses on understanding host-microbe interactions in the gut and how the immune system maintains tolerance during chronic infection. Learn more: bit.ly/3WXgr2V
Reposted by Reinhard Hinterleitner
Check out our new publication, a collaboration with Giovanni Luchetti and Vishva Dixit @ Genentech.
We show that the E.coli effector NleL inhibits intestinal epithelial cell extrusion after #inflammasome activation via degrading the kinases ROCK1 and 2!!
www.nature.com/articles/s41...
Explainer 1/8
We show that the E.coli effector NleL inhibits intestinal epithelial cell extrusion after #inflammasome activation via degrading the kinases ROCK1 and 2!!
www.nature.com/articles/s41...
Explainer 1/8
Enteropathogenic bacteria evade ROCK-driven epithelial cell extrusion - Nature
The bacterial ubiquitin ligase NleL evades host defence mechanisms both by inhibiting pyroptosis and by preventing infected intestinal epithelial cells from being extruded into the lumen and expelled ...
www.nature.com
October 22, 2025 at 3:47 PM
Check out our new publication, a collaboration with Giovanni Luchetti and Vishva Dixit @ Genentech.
We show that the E.coli effector NleL inhibits intestinal epithelial cell extrusion after #inflammasome activation via degrading the kinases ROCK1 and 2!!
www.nature.com/articles/s41...
Explainer 1/8
We show that the E.coli effector NleL inhibits intestinal epithelial cell extrusion after #inflammasome activation via degrading the kinases ROCK1 and 2!!
www.nature.com/articles/s41...
Explainer 1/8
Reposted by Reinhard Hinterleitner
Preview @cp-immunity.bsky.social
Cutting the Gordian knot: Untangling gasdermin C from pyroptosis
www.cell.com/immunity/ful...
on
www.cell.com/immunity/ful...
Cutting the Gordian knot: Untangling gasdermin C from pyroptosis
www.cell.com/immunity/ful...
on
www.cell.com/immunity/ful...
October 14, 2025 at 9:47 PM
Preview @cp-immunity.bsky.social
Cutting the Gordian knot: Untangling gasdermin C from pyroptosis
www.cell.com/immunity/ful...
on
www.cell.com/immunity/ful...
Cutting the Gordian knot: Untangling gasdermin C from pyroptosis
www.cell.com/immunity/ful...
on
www.cell.com/immunity/ful...
Reposted by Reinhard Hinterleitner
Tenure-track Assistant Professor position in Bioinformatics in the Department of Biology at the University of San Francisco
usfca.wd5.myworkdayjobs.com/en-US/USF_Fu...
usfca.wd5.myworkdayjobs.com/en-US/USF_Fu...
Assistant Professor, Tenure-Track, Department of Biology, University of San Francisco
Job Title: Assistant Professor, Tenure-Track, Department of Biology, University of San Francisco Job Summary: The Department of Biology at the University of San Francisco invites applications for a fu...
usfca.wd5.myworkdayjobs.com
September 27, 2025 at 11:55 AM
Tenure-track Assistant Professor position in Bioinformatics in the Department of Biology at the University of San Francisco
usfca.wd5.myworkdayjobs.com/en-US/USF_Fu...
usfca.wd5.myworkdayjobs.com/en-US/USF_Fu...
Reposted by Reinhard Hinterleitner
Looking forward to the 23rd annual Department of Immunology retreat tomorrow! It's always a great time to catch up on #immunology research and connect with colleagues. Shout out to the organizing committee and grad student Sarah Bradley for designing this year's poster.
September 24, 2025 at 8:05 PM
Looking forward to the 23rd annual Department of Immunology retreat tomorrow! It's always a great time to catch up on #immunology research and connect with colleagues. Shout out to the organizing committee and grad student Sarah Bradley for designing this year's poster.
Reposted by Reinhard Hinterleitner
Congrats, @catmphelps.bsky.social !
Congratulations to PMI student @catmphelps.bsky.social who is the recipient of the 23rd Stephen L. Phillips Scientific Achievement award for a Pitt School of Medicine graduate student who authored the best peer-review scientific journal author this year!
September 24, 2025 at 9:06 PM
Congrats, @catmphelps.bsky.social !
Reposted by Reinhard Hinterleitner
👋 Hello Bluesky! We are the Pitt Department of Immunology. From autoimmune disease and cancer immunotherapy to vaccine development to infectious disease, our work spans the spectrum of immunological science. Follow along for updates on the latest publications and other news!
September 24, 2025 at 6:09 PM
👋 Hello Bluesky! We are the Pitt Department of Immunology. From autoimmune disease and cancer immunotherapy to vaccine development to infectious disease, our work spans the spectrum of immunological science. Follow along for updates on the latest publications and other news!
Excited to share our new publication in collaboration with Yi-Nan Gong: Gasdermin C cleavage by Cathepsin S modulates Rab7 vesicles in intestinal epithelial cells to amplify anti-helminth immunity: Immunity www.cell.com/immunity/ful...
Gasdermin C cleavage by Cathepsin S modulates Rab7 vesicles in intestinal epithelial cells to amplify anti-helminth immunity
Pandey et al. identify Cathepsin S (CTSS) as the direct protease that cleaves Gasdermin
C (GsdmC) in the intestine. Type 2 immune-promoting microbes trigger CTSS-dependent
GsdmC activation in intestin...
www.cell.com
July 22, 2025 at 3:26 PM
Excited to share our new publication in collaboration with Yi-Nan Gong: Gasdermin C cleavage by Cathepsin S modulates Rab7 vesicles in intestinal epithelial cells to amplify anti-helminth immunity: Immunity www.cell.com/immunity/ful...
Reposted by Reinhard Hinterleitner
The Global Grants for Gut Health are now open. If your research explores how nutrition affects the gut #microbiome or barrier function, you may be eligible to apply for one of three grants each offering up to USD$100K. Apply here: go.nature.com/4kb9cO1 #Academicsky 🍎📃
July 16, 2025 at 4:00 PM
The Global Grants for Gut Health are now open. If your research explores how nutrition affects the gut #microbiome or barrier function, you may be eligible to apply for one of three grants each offering up to USD$100K. Apply here: go.nature.com/4kb9cO1 #Academicsky 🍎📃
Reposted by Reinhard Hinterleitner
Welcome to #InnovationsSymposium2025! We’re excited to be together again—this year on the beautiful island of Oʻahu—to hear the latest #IBD research and encourage dialogue and connections that continue to move the work forward.
July 18, 2025 at 6:32 PM
Welcome to #InnovationsSymposium2025! We’re excited to be together again—this year on the beautiful island of Oʻahu—to hear the latest #IBD research and encourage dialogue and connections that continue to move the work forward.
Reposted by Reinhard Hinterleitner
Our lab just completed a +6 year #marathon, describing for the first time that the #microbiome is critical for #exercise - induced increases in antitumor CD8 T cell immunity and improved of #cancer #immunotherapy.
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy
Exercise enhances antitumor immunity and immunotherapy effectiveness by increasing
microbiota-derived formate, which boosts CD8 T cell function and may serve as a biomarker
of melanoma suppression.
www.cell.com
July 9, 2025 at 6:12 PM
Our lab just completed a +6 year #marathon, describing for the first time that the #microbiome is critical for #exercise - induced increases in antitumor CD8 T cell immunity and improved of #cancer #immunotherapy.
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by Reinhard Hinterleitner
The unintended consequences of a gut microbiome transplant
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...
Microbiome mismatches from microbiota transplants lead to persistent off-target metabolic and immunomodulatory effects
Fecal microbiota transplants (FMTs) may not always effectively restore small bowel
microbiota due to regional differences in gut environments, potentially causing unintended
effects on metabolism and ...
www.cell.com
June 6, 2025 at 2:43 PM
The unintended consequences of a gut microbiome transplant
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...
Reposted by Reinhard Hinterleitner
Immunoglobulin A controls intestinal virus colonization to preserve immune homeostasis
www.cell.com/cell-host-mi...
www.cell.com/cell-host-mi...
March 28, 2025 at 1:57 AM
Immunoglobulin A controls intestinal virus colonization to preserve immune homeostasis
www.cell.com/cell-host-mi...
www.cell.com/cell-host-mi...
Reposted by Reinhard Hinterleitner
Let's not forget that apart from science advocacy the Rauch lab also does kick-ass science!
Together with the @psmitchej.bsky.social and Tait Wojno labs, we show that #tuftcells can induce specific protective signaling after recognition of intracellular bacterial infection via the #inflammasome!
Together with the @psmitchej.bsky.social and Tait Wojno labs, we show that #tuftcells can induce specific protective signaling after recognition of intracellular bacterial infection via the #inflammasome!
First authors Madeline Churchill and Ankit Pandeya @nkeet50.bsky.social from @rauchlab.bsky.social show that tuft cells, known for their role in anti-parasite defenses, can also contribute to anti-bacterial responses in the small intestine. rupress.org/jem/article/...
#InfectiousDisease
#InfectiousDisease
March 13, 2025 at 4:31 PM
Let's not forget that apart from science advocacy the Rauch lab also does kick-ass science!
Together with the @psmitchej.bsky.social and Tait Wojno labs, we show that #tuftcells can induce specific protective signaling after recognition of intracellular bacterial infection via the #inflammasome!
Together with the @psmitchej.bsky.social and Tait Wojno labs, we show that #tuftcells can induce specific protective signaling after recognition of intracellular bacterial infection via the #inflammasome!
Reposted by Reinhard Hinterleitner
Stand Up for Science Rally in Pittsburgh
March 7, 2025 at 4:05 PM
Stand Up for Science Rally in Pittsburgh
Reposted by Reinhard Hinterleitner
#KSHostMicrobe25 in beautiful Banff-such an awesome meeting. Was great to talk at the @keystonesymposia.bsky.social about exciting work from the lab about how we can take advantage of the microbiota metabolites to improve cancer immunotherapy efficacy
#microbiota #immunometabolism #cancer
#microbiota #immunometabolism #cancer
February 22, 2025 at 6:54 PM
#KSHostMicrobe25 in beautiful Banff-such an awesome meeting. Was great to talk at the @keystonesymposia.bsky.social about exciting work from the lab about how we can take advantage of the microbiota metabolites to improve cancer immunotherapy efficacy
#microbiota #immunometabolism #cancer
#microbiota #immunometabolism #cancer
Reposted by Reinhard Hinterleitner
Homeostatic antiviral protection of the neonatal gut epithelium by interferon lambda: Cell Reports www.cell.com/cell-reports...
Newborns lack immune memory to viral pathogens, so wouldn't it make sense to pre-emptively turn on antiviral defenses in barrier tissues such as the intestine at birth?
Newborns lack immune memory to viral pathogens, so wouldn't it make sense to pre-emptively turn on antiviral defenses in barrier tissues such as the intestine at birth?
Homeostatic antiviral protection of the neonatal gut epithelium by interferon lambda
Enteric viral infections are a major public health problem in newborns. Ramirez Reyes
et al. find that the immature intestinal epithelium of newborn mice is developmentally
programmed for the homeosta...
www.cell.com
February 4, 2025 at 5:11 PM
Homeostatic antiviral protection of the neonatal gut epithelium by interferon lambda: Cell Reports www.cell.com/cell-reports...
Newborns lack immune memory to viral pathogens, so wouldn't it make sense to pre-emptively turn on antiviral defenses in barrier tissues such as the intestine at birth?
Newborns lack immune memory to viral pathogens, so wouldn't it make sense to pre-emptively turn on antiviral defenses in barrier tissues such as the intestine at birth?
Reposted by Reinhard Hinterleitner
Why scratching makes a rash worse and a potential benefit to scratching--it reduced S. aureus on skin. Andrew Liu's paper from our lab is out now at #science #neuroimmune #immunology www.science.org/doi/10.1126/...
Scratching promotes allergic inflammation and host defense via neurogenic mast cell activation
Itch is a dominant symptom in dermatitis, and scratching promotes cutaneous inflammation, thereby worsening disease. However, the mechanisms through which scratching exacerbates inflammation and wheth...
www.science.org
January 30, 2025 at 8:31 PM
Why scratching makes a rash worse and a potential benefit to scratching--it reduced S. aureus on skin. Andrew Liu's paper from our lab is out now at #science #neuroimmune #immunology www.science.org/doi/10.1126/...
Reposted by Reinhard Hinterleitner
Don't miss your chance to showcase your research with a poster presentation! Submit by Jan. 28, 11:59pm MST. Be part of an exciting gathering with experts like @institutimagine.bsky.social, @reisesousalab.bsky.social and many others this February in Banff, Canada. hubs.la/Q032JT3R0 #KSHostMicrobe25
January 20, 2025 at 5:12 PM
Don't miss your chance to showcase your research with a poster presentation! Submit by Jan. 28, 11:59pm MST. Be part of an exciting gathering with experts like @institutimagine.bsky.social, @reisesousalab.bsky.social and many others this February in Banff, Canada. hubs.la/Q032JT3R0 #KSHostMicrobe25
Reposted by Reinhard Hinterleitner
was a joy to write review about the systemic immunoregulatory functions of L. reuteri with @pitt-pmi.bsky.social student Amanda and postdoc Daphne. check it out. www.tandfonline.com/doi/full/10....
Limosilactobacillus reuteri - a probiotic gut commensal with contextual impact on immunity
The gut microbiome plays a key role in human health, influencing various biological processes and disease outcomes. The historical roots of probiotics are traced back to Nobel Laureate Élie Metchni...
www.tandfonline.com
January 18, 2025 at 1:49 PM
was a joy to write review about the systemic immunoregulatory functions of L. reuteri with @pitt-pmi.bsky.social student Amanda and postdoc Daphne. check it out. www.tandfonline.com/doi/full/10....
Reposted by Reinhard Hinterleitner
Congrats @cicacanesso.bsky.social !
#Immunology by First release now @science.org
Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection
https://buff.ly/3DjNQ1e
By Maria Canesso, @danmucida.bsky.social , @victora.bsky.social and colleagues.
Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection
https://buff.ly/3DjNQ1e
By Maria Canesso, @danmucida.bsky.social , @victora.bsky.social and colleagues.
December 19, 2024 at 8:23 PM
Congrats @cicacanesso.bsky.social !
Reposted by Reinhard Hinterleitner
Ever wondered how gut microbes control immune responses at extra-intestinal locations?
Here #theonlylabever reports how a gut protozoan commensal shapes pulmonary immunity to exacerbate asthma and limit the dissemination of mycobacteria.
@cellpress.bsky.social ⬇️(1/x)
www.cell.com/cell/fulltex...
Here #theonlylabever reports how a gut protozoan commensal shapes pulmonary immunity to exacerbate asthma and limit the dissemination of mycobacteria.
@cellpress.bsky.social ⬇️(1/x)
www.cell.com/cell/fulltex...
December 19, 2024 at 9:30 PM
Ever wondered how gut microbes control immune responses at extra-intestinal locations?
Here #theonlylabever reports how a gut protozoan commensal shapes pulmonary immunity to exacerbate asthma and limit the dissemination of mycobacteria.
@cellpress.bsky.social ⬇️(1/x)
www.cell.com/cell/fulltex...
Here #theonlylabever reports how a gut protozoan commensal shapes pulmonary immunity to exacerbate asthma and limit the dissemination of mycobacteria.
@cellpress.bsky.social ⬇️(1/x)
www.cell.com/cell/fulltex...
Reposted by Reinhard Hinterleitner
We're hiring! Funded postdoctoral position available in the Moltke Lab. 79k starting salary and access to a fellowship program in the Institute for Translational Immunology that offers both academic and industry training tracks. Details here: jobrxiv.org/job/universi...
Postdoctoral Fellow - Moltke Lab
Post a job in 3min, or find thousands of job offers like this one at jobRxiv!
jobrxiv.org
December 17, 2024 at 11:58 PM
We're hiring! Funded postdoctoral position available in the Moltke Lab. 79k starting salary and access to a fellowship program in the Institute for Translational Immunology that offers both academic and industry training tracks. Details here: jobrxiv.org/job/universi...