Babak Razani, MD, PhD Laboratory
@razanilab.bsky.social
The Razani lab (www.razani.org) @ Center for Immunometabolism (cim.pitt.edu) and Vascular Medicine Institute (vmi.pitt.edu), University of Pittsburgh studies macrophages, autophagy-lysosomes, & nutrient sensing/signaling in metabolic disease
We thank all our @razanilab.bsky.social members and many collaborators in making this happen 🤝
March 19, 2025 at 1:41 PM
We thank all our @razanilab.bsky.social members and many collaborators in making this happen 🤝
Lysosomal Acid #Lipase (Lipa/LAL) is upregulated in #AdiposeTissue during #fasting, cold exposure, and even #obesity. When we ablate #adipocyte Lipa/LAL, mice cannot undergo full #lipolysis with difficulty maintaining body temperature in cold. On #highfat diet, they become obese.
March 19, 2025 at 1:41 PM
Lysosomal Acid #Lipase (Lipa/LAL) is upregulated in #AdiposeTissue during #fasting, cold exposure, and even #obesity. When we ablate #adipocyte Lipa/LAL, mice cannot undergo full #lipolysis with difficulty maintaining body temperature in cold. On #highfat diet, they become obese.