Pinned
Subramaniam Lab
@rasilab.bsky.social
· May 29
ReLiC is an RNA-linked CRISPR platform for dissecting RNA metabolic processes, revealing key regulators of RNA splicing, translation and decay. @rasilab.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Our RNA-linked CRISPR approach is now published! Work led by fantastic graduate student in the lab, Patrick Nugent.
Our RNA-linked CRISPR approach is now published! Work led by fantastic graduate student in the lab, Patrick Nugent.
ReLiC is an RNA-linked CRISPR platform for dissecting RNA metabolic processes, revealing key regulators of RNA splicing, translation and decay. @rasilab.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
May 29, 2025 at 4:39 PM
Our RNA-linked CRISPR approach is now published! Work led by fantastic graduate student in the lab, Patrick Nugent.
Excited to share the work of postdoc Rachael Bakker in collaboration with @lapointelab.bsky.social!
We show that RNA base editors can be repurposed for deep mutational scanning of RNA-RBP interactions at scale both in vitro and in vivo.
www.biorxiv.org/content/10.1...
We show that RNA base editors can be repurposed for deep mutational scanning of RNA-RBP interactions at scale both in vitro and in vivo.
www.biorxiv.org/content/10.1...
Deaminase-based RNA recording enables high throughput mutational profiling of protein-RNA interactions
Protein-RNA interactions govern nearly every aspect of RNA metabolism and are frequently dysregulated in disease. While individual protein residues and RNA nucleotides critical for these interactions ...
www.biorxiv.org
May 2, 2025 at 12:16 AM
Excited to share the work of postdoc Rachael Bakker in collaboration with @lapointelab.bsky.social!
We show that RNA base editors can be repurposed for deep mutational scanning of RNA-RBP interactions at scale both in vitro and in vivo.
www.biorxiv.org/content/10.1...
We show that RNA base editors can be repurposed for deep mutational scanning of RNA-RBP interactions at scale both in vitro and in vivo.
www.biorxiv.org/content/10.1...