Checkout our latest research in @natcomms.nature.com
rdcu.be/eBqBI A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells. A collaboration with Mike Boemo’s team

We are hiring!
We are looking for a motivated and enthusiastic postdoc to study mammalian DSB repair using innovative genomic approaches.
Our lab is at the Curie Institute in Paris and offers vibrant scientific environnement and cutting edge platforms.
Please repost or apply here:
lnkd.in/eJ9q3QrR

Our paper is now out in Molecular Cell!

Check the thread in this former post:

www.cell.com/molecular-ce...

Hi everyone!

The latest method from the Whitehouse lab: PCP


PCP uses a novel proximity barcoding strategy to simultaneously map 3D genome organization at various resolutions at the single molecule level:

Out soon, check the updated BioRxiv – little thread:

1/11
www.biorxiv.org/content/10.1...

New paper! Most human DNA replication initiation is dispersed throughout the genome with only a minority within previously identified initiation zones

genomebiology.biomedcentral.com/articles/10....

Identifying human DNA replication initiation sites on single molecules by @nanoporetech.com 1/7

Hello World! Are you passionate about epigenomics and evolution 🧪🧬🐭🐵 ? Are you looking for a postdoc in a stimulating and inclusive environment ? Look no further... We are seeking creative postdocs for our ERC project EvoEpi @igred.fr ! 👇Details👇
tinyurl.com/PostdocEvoEp...
Repost are appreciated

🐣 What comes first — R-loops or genome instability?

There’s now a Behind the Paper to go with our recent study on the interplay between R-loops and DNA damage — with some context, backstory, and the chicken-and-egg question at its core.

Check it out 👉 go.nature.com/4ldXbJm

🥚🔄🐓 - Another narrative of our last paper: communities.springernature.com/posts/r-loop...

How are chromosome breaks repaired and how is their repair influenced and facilitated by nuclear and genome dynamics? Fantastic initiative and collaboration with @karimmekhail.bsky.social, @chiololab.bsky.social, and @lablegube.bsky.social. @natrevmcb.bsky.social Link to article: rdcu.be/edViW

Much grateful to @agencerecherche.bsky.social , @fondationarc.bsky.social and Ligue Nationale contre le Cancer for funding this project ! (7/8)

Congratulations to first author @raphaelmngn.bsky.social and many thanks to all our great collaborators 🧑‍🎓 - Rodney Rothstein @columbiamed.bsky.social, Sergio de Almeida @gimmfoundation.bsky.social, Peter Stirling @BCCancer and Pierre-Henri Gaillard @crcm.bsky.social (6/8)

Such « post-lesion » hybrids can be detected in yeast and human cells, yet they do not detectably impact genome stability, as opposed to « pre-lesion » hybrids - a revisited classification? (5/8)

For example, focusing on Okazaki fragments (OF) processing, we found that the accumulation of unprocessed flaps or unligated OF termini is the source of hybrid formation 🧬 (4/8)

We identified several situations where DNA:RNA hybrids are associated with genetic instability – strikingly, in most cases, DNA lesions appear to precede hybrid formation 🔃 (3/8)

🎉 Exciting News! 🎉

I’m super excited to share that my PhD work has just been published in Nature Communications! ✨

If you're curious about the discoveries we made, feel free to check out the thread below 😉.

Thanks to everyone who has been part of this journey! 🚀🧬

Full article : rdcu.be/ec1ET

In this study, we systematically explored the relationships between DNA:RNA hybrid formation and genetic instability, through a suite of genetic screens in yeast 🧬 (2/8)

Pleased to launch the Palancade lab Bluesky account with our new paper 📝, now out at @naturecomms.bsky.social (1/8)