Rajib Gupta
@rajgupta-renalpath.bsky.social
Renal pathologist with special interest in MGRS; Johns Hopkins renal path alumnus; associate professor at UC Davis.
Reposted by Rajib Gupta
Dual-Antigen Membranous Nephropathy
doi.org/10.1016/j.kint.2025.10.006
#NephSky #MedSky #membranousnephropathy @mayoclinicpath.bsky.social @arkanalabs.bsky.social @lynncornell.bsky.social @aaronstorey.bsky.social
doi.org/10.1016/j.kint.2025.10.006
#NephSky #MedSky #membranousnephropathy @mayoclinicpath.bsky.social @arkanalabs.bsky.social @lynncornell.bsky.social @aaronstorey.bsky.social
November 4, 2025 at 10:16 PM
Reposted by Rajib Gupta
Research suggests Clonal hematopoiesis of indeterminate potential (CHIP) may contribute to CKD and its comorbidities, necessitating additional research. https://bit.ly/JASN0739
@drflashheart.bsky.social
@pnatarajanmd.bsky.social
@zhiyu.bsky.social
#ASNJASN
@drflashheart.bsky.social
@pnatarajanmd.bsky.social
@zhiyu.bsky.social
#ASNJASN
May 15, 2025 at 6:00 PM
Research suggests Clonal hematopoiesis of indeterminate potential (CHIP) may contribute to CKD and its comorbidities, necessitating additional research. https://bit.ly/JASN0739
@drflashheart.bsky.social
@pnatarajanmd.bsky.social
@zhiyu.bsky.social
#ASNJASN
@drflashheart.bsky.social
@pnatarajanmd.bsky.social
@zhiyu.bsky.social
#ASNJASN
Reposted by Rajib Gupta
Interesting case of AL-amyloidosis, kappa type. IF showed clear kappa restriction(pictured); amyloid A IHC was very strong but mass spec confirmed AL-k amyloid (patient has a k-plasma cell dyscrasia). Never seen so much non-specific AA staining before. Mass spec FTW. #renalpath #pathsky #nephsky
May 16, 2025 at 3:05 PM
Interesting case of AL-amyloidosis, kappa type. IF showed clear kappa restriction(pictured); amyloid A IHC was very strong but mass spec confirmed AL-k amyloid (patient has a k-plasma cell dyscrasia). Never seen so much non-specific AA staining before. Mass spec FTW. #renalpath #pathsky #nephsky
Reposted by Rajib Gupta
A polyoma virus 'crescents' in a case of BK nephropathy in a kidney transplant patient. SV40 demonstrates parietal epithelial cell positivity on deeper levels. BK viremia >3 million recently. #renalpath #pathsky #nephsky
May 6, 2025 at 2:00 PM
A polyoma virus 'crescents' in a case of BK nephropathy in a kidney transplant patient. SV40 demonstrates parietal epithelial cell positivity on deeper levels. BK viremia >3 million recently. #renalpath #pathsky #nephsky
Intra-capillary occlusive basophilic polymer "emboli" caught incidentally in the allograft biopsy of a patient with longstanding peripheral vascular disease (PVD) who purportedly had a recent procedure for PVD treatment while on a visit to another country.
May 10, 2025 at 3:20 AM
Intra-capillary occlusive basophilic polymer "emboli" caught incidentally in the allograft biopsy of a patient with longstanding peripheral vascular disease (PVD) who purportedly had a recent procedure for PVD treatment while on a visit to another country.
Reposted by Rajib Gupta
The IKMG 7th International meeting will be held September 26-27th, 2025 in Lisbon, Portugal.
To see the preliminary program & register for the meeting by September 19, 2025, please visit: ikmg2025.com
Early bird pricing ends June 1, 2025
#pathsky #nephsky #medsky
To see the preliminary program & register for the meeting by September 19, 2025, please visit: ikmg2025.com
Early bird pricing ends June 1, 2025
#pathsky #nephsky #medsky
May 5, 2025 at 9:53 PM
The IKMG 7th International meeting will be held September 26-27th, 2025 in Lisbon, Portugal.
To see the preliminary program & register for the meeting by September 19, 2025, please visit: ikmg2025.com
Early bird pricing ends June 1, 2025
#pathsky #nephsky #medsky
To see the preliminary program & register for the meeting by September 19, 2025, please visit: ikmg2025.com
Early bird pricing ends June 1, 2025
#pathsky #nephsky #medsky
Reposted by Rajib Gupta
Save the Date for the 6th International Renal Pathology Conference in Antigua, Guatemala, February 11-14, 2026! Chair:Carmen Avila
@asnkidney.bsky.social @theisn.org @kidney.org @csnscn.bsky.social @ukkidney.org @senefrologia.bsky.social @sfndt.bsky.social @oegn.bsky.social
#pathsky #nephsky #medsky
@asnkidney.bsky.social @theisn.org @kidney.org @csnscn.bsky.social @ukkidney.org @senefrologia.bsky.social @sfndt.bsky.social @oegn.bsky.social
#pathsky #nephsky #medsky
May 5, 2025 at 9:57 PM
Save the Date for the 6th International Renal Pathology Conference in Antigua, Guatemala, February 11-14, 2026! Chair:Carmen Avila
@asnkidney.bsky.social @theisn.org @kidney.org @csnscn.bsky.social @ukkidney.org @senefrologia.bsky.social @sfndt.bsky.social @oegn.bsky.social
#pathsky #nephsky #medsky
@asnkidney.bsky.social @theisn.org @kidney.org @csnscn.bsky.social @ukkidney.org @senefrologia.bsky.social @sfndt.bsky.social @oegn.bsky.social
#pathsky #nephsky #medsky
Reposted by Rajib Gupta
Hematuria is an undisputable biomarker of IgAN, although with "insufficient specificity"
#Nephpearls #NephSky
👉 pubmed.ncbi.nlm.nih.gov/28739649/
#Nephpearls #NephSky
👉 pubmed.ncbi.nlm.nih.gov/28739649/
May 1, 2025 at 12:09 AM
Hematuria is an undisputable biomarker of IgAN, although with "insufficient specificity"
#Nephpearls #NephSky
👉 pubmed.ncbi.nlm.nih.gov/28739649/
#Nephpearls #NephSky
👉 pubmed.ncbi.nlm.nih.gov/28739649/
Reposted by Rajib Gupta
Pt with CMML & subnephrotic proteinuria & renal dysfunction
Extramedullary hematopoiesis
•Hematopoietic tissue outside BM
•Due to hematologic malignancy/lack BM hematopoiesis (HP)
•Histology: TIN + trilineage HP
#renalpath #pathsky #nephsky #hemepath
Extramedullary hematopoiesis
•Hematopoietic tissue outside BM
•Due to hematologic malignancy/lack BM hematopoiesis (HP)
•Histology: TIN + trilineage HP
#renalpath #pathsky #nephsky #hemepath
April 16, 2025 at 4:28 AM
Pt with CMML & subnephrotic proteinuria & renal dysfunction
Extramedullary hematopoiesis
•Hematopoietic tissue outside BM
•Due to hematologic malignancy/lack BM hematopoiesis (HP)
•Histology: TIN + trilineage HP
#renalpath #pathsky #nephsky #hemepath
Extramedullary hematopoiesis
•Hematopoietic tissue outside BM
•Due to hematologic malignancy/lack BM hematopoiesis (HP)
•Histology: TIN + trilineage HP
#renalpath #pathsky #nephsky #hemepath
Reposted by Rajib Gupta
Are you a patient with Alport syndrome? The 2025 In-Person Alport Connect meeting will be in Chicago on July 19-20th. Child and teen programming available. See you there! alportsyndrome.org/for-patients...
March 24, 2025 at 4:12 PM
Are you a patient with Alport syndrome? The 2025 In-Person Alport Connect meeting will be in Chicago on July 19-20th. Child and teen programming available. See you there! alportsyndrome.org/for-patients...
Reposted by Rajib Gupta
Happy to share our publication on a case of Minimal Change Podocytopathy with coexisting Thin Basement Membrane following exposure to Semaglutide @juancarlosqvelez.bsky.social
karger.com/gdz/article/...
karger.com/gdz/article/...
Minimal Change Podocytopathy with Coexistent Thin Glomerular Basement Membrane following Exposure to Semaglutide
Abstract. Introduction: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are FDA-approved for weight loss and are increasingly prescribed for patients with obesity and type 2 diabetes mellitus. Mu...
karger.com
March 3, 2025 at 3:54 PM
Happy to share our publication on a case of Minimal Change Podocytopathy with coexisting Thin Basement Membrane following exposure to Semaglutide @juancarlosqvelez.bsky.social
karger.com/gdz/article/...
karger.com/gdz/article/...
Reposted by Rajib Gupta
The autoimmune architecture of childhood idiopathic #nephroticsyndrome
doi.org/10.1016/j.kint.2024.10.027
#KIMiniReview #OpenAccess #NephSky #SkyNeph #MedSky
doi.org/10.1016/j.kint.2024.10.027
#KIMiniReview #OpenAccess #NephSky #SkyNeph #MedSky
January 7, 2025 at 9:05 PM
The autoimmune architecture of childhood idiopathic #nephroticsyndrome
doi.org/10.1016/j.kint.2024.10.027
#KIMiniReview #OpenAccess #NephSky #SkyNeph #MedSky
doi.org/10.1016/j.kint.2024.10.027
#KIMiniReview #OpenAccess #NephSky #SkyNeph #MedSky
Reposted by Rajib Gupta
Interested in learning about the CRLF2 assay by flow cytometry, and perhaps performing it in your lab? Check out this module from the International Clinical Cytometry Society for tips!
#HemePath #FlowCytometry #FlowEdu
#HemePath #FlowCytometry #FlowEdu
Detection of CRLF2 expression by flow cytometry in B-ALL is a useful screening tool for identifying cases with CRLF2 rearrangements & JAK2 mutations. Check out this module from the ICCS Q&S Committee for assay instructions: www.cytometry.org/web/modules/...
#Pathsky #hemepath #flowcytometry
#Pathsky #hemepath #flowcytometry
January 7, 2025 at 8:56 PM
Interested in learning about the CRLF2 assay by flow cytometry, and perhaps performing it in your lab? Check out this module from the International Clinical Cytometry Society for tips!
#HemePath #FlowCytometry #FlowEdu
#HemePath #FlowCytometry #FlowEdu
1st case on BlueSky -
Acute cryoglobulinemic GN in an adult patient with elevated HCV viral load and positive HCV RNA; Immunofluorescence shows positive cryo staining for IgG, IgM (IgM>IgG), C3, kappa and lambda; EM image shows fragmented cryo within capillary loop with swollen endothelial cell.
Acute cryoglobulinemic GN in an adult patient with elevated HCV viral load and positive HCV RNA; Immunofluorescence shows positive cryo staining for IgG, IgM (IgM>IgG), C3, kappa and lambda; EM image shows fragmented cryo within capillary loop with swollen endothelial cell.
December 15, 2024 at 8:45 PM
1st case on BlueSky -
Acute cryoglobulinemic GN in an adult patient with elevated HCV viral load and positive HCV RNA; Immunofluorescence shows positive cryo staining for IgG, IgM (IgM>IgG), C3, kappa and lambda; EM image shows fragmented cryo within capillary loop with swollen endothelial cell.
Acute cryoglobulinemic GN in an adult patient with elevated HCV viral load and positive HCV RNA; Immunofluorescence shows positive cryo staining for IgG, IgM (IgM>IgG), C3, kappa and lambda; EM image shows fragmented cryo within capillary loop with swollen endothelial cell.
Reposted by Rajib Gupta
Nice review on the cross talk between glomeruli and tubules and the complex interplay between them that underlies progressive kidney injury. From two of my fantastic colleagues Dr. Harris and Dr. Fogo! @vumc-insights.bsky.social www.nature.com/articles/s41...
Crosstalk between glomeruli and tubules - Nature Reviews Nephrology
Glomerular injury and damage to the glomerular filtration barrier can promote the development of tubulointerstitial fibrosis. Here, the authors discuss potential mechanisms underlying this effect, as ...
www.nature.com
December 14, 2024 at 12:03 PM
Nice review on the cross talk between glomeruli and tubules and the complex interplay between them that underlies progressive kidney injury. From two of my fantastic colleagues Dr. Harris and Dr. Fogo! @vumc-insights.bsky.social www.nature.com/articles/s41...
Reposted by Rajib Gupta
New (FREE) on the #AJKDBlog:
Timothy Yau interviews Dr. Anuja Java about Clinical Genetic Testing in Nephrology: Core Curriculum 2024
https://bit.ly/3VtjcZp
Timothy Yau interviews Dr. Anuja Java about Clinical Genetic Testing in Nephrology: Core Curriculum 2024
https://bit.ly/3VtjcZp
December 14, 2024 at 5:00 PM
New (FREE) on the #AJKDBlog:
Timothy Yau interviews Dr. Anuja Java about Clinical Genetic Testing in Nephrology: Core Curriculum 2024
https://bit.ly/3VtjcZp
Timothy Yau interviews Dr. Anuja Java about Clinical Genetic Testing in Nephrology: Core Curriculum 2024
https://bit.ly/3VtjcZp
Reposted by Rajib Gupta
Interested in onconephrology?
Here is an interesting study reporting renal biopsies with anticancer drug use: registry data from 🇯🇵: interstitial nephritis and TMA most common with cancer chemotherapy, GN often in association with immune checkpoint inhibitors
academic.oup.com/ckj/article/...
Here is an interesting study reporting renal biopsies with anticancer drug use: registry data from 🇯🇵: interstitial nephritis and TMA most common with cancer chemotherapy, GN often in association with immune checkpoint inhibitors
academic.oup.com/ckj/article/...
SUrvey of renal Biopsy registry database and Anticancer dRUg therapy in Japan (SUBARU-J study)
ABSTRACTBackground. Kidney complications associated with anticancer drug therapy have greatly increased recently. We aimed to investigate the real-world cl
academic.oup.com
December 6, 2024 at 5:54 AM
Interested in onconephrology?
Here is an interesting study reporting renal biopsies with anticancer drug use: registry data from 🇯🇵: interstitial nephritis and TMA most common with cancer chemotherapy, GN often in association with immune checkpoint inhibitors
academic.oup.com/ckj/article/...
Here is an interesting study reporting renal biopsies with anticancer drug use: registry data from 🇯🇵: interstitial nephritis and TMA most common with cancer chemotherapy, GN often in association with immune checkpoint inhibitors
academic.oup.com/ckj/article/...
Reposted by Rajib Gupta
Absence of proteinuria may not be trustworthy evidence that IgAN treatment is working. #iganephropathy #igan #kidneywk #kidneydisease #nephsky
Renal Biopsy May Be Needed to Determine Treatment Efficacy in IgAN | Docwire News
Clinical improvement does not always reflect pathology, so renal biopsy may be needed to determine efficacy of IgA nephropathy (IgAN) treatment.
buff.ly
December 5, 2024 at 10:00 PM
Absence of proteinuria may not be trustworthy evidence that IgAN treatment is working. #iganephropathy #igan #kidneywk #kidneydisease #nephsky
Reposted by Rajib Gupta
Reposted by Rajib Gupta
The photomicrograph shows glomerular tuft retraction with markedly corrugated glomerular basement membranes and periglomerular fibrosis. (1/2)
December 3, 2024 at 2:39 PM
The photomicrograph shows glomerular tuft retraction with markedly corrugated glomerular basement membranes and periglomerular fibrosis. (1/2)
Reposted by Rajib Gupta
Diagnosis, management and treatment of the #Alport syndrome – 2024 #guideline on behalf of ERKNet, ERA and ESPN
#nephsky
academic.oup.com/ndt/advance-...
#nephsky
academic.oup.com/ndt/advance-...
Diagnosis, management and treatment of the Alport syndrome – 2024 guideline on behalf of ERKNet, ERA and ESPN
Abstract. Glomerular nephropathy resulting from the genetic defects in COL4A3/4/5 genes including the classical Alport syndrome (AS) is the second commones
academic.oup.com
December 3, 2024 at 2:04 AM
Diagnosis, management and treatment of the #Alport syndrome – 2024 #guideline on behalf of ERKNet, ERA and ESPN
#nephsky
academic.oup.com/ndt/advance-...
#nephsky
academic.oup.com/ndt/advance-...
Reposted by Rajib Gupta
Another relatively common finding in lupus nephritis EM evaluation. Cytoplasmic myelin bodies most likely related to hydroxychloroquine effect. In this case present in rare endothelial cell. Some vague laminated structures in tubular lysosomes as well.
#renalpath
#nephrology
#pathsky
#nephsky
#renalpath
#nephrology
#pathsky
#nephsky
November 29, 2024 at 5:56 PM
Another relatively common finding in lupus nephritis EM evaluation. Cytoplasmic myelin bodies most likely related to hydroxychloroquine effect. In this case present in rare endothelial cell. Some vague laminated structures in tubular lysosomes as well.
#renalpath
#nephrology
#pathsky
#nephsky
#renalpath
#nephrology
#pathsky
#nephsky
Reposted by Rajib Gupta
"Obesity defined by high BMI is highly prevalent in people with CKD, and patients have health, health care, and social disparity"
"...G3-4 with a BMI ≥30 appeared to have a higher risk of CKD progression and ... CKD G5D with BMI ≥30 kg/m2 were less likely to receive transplant"
shorturl.at/hoWXj
"...G3-4 with a BMI ≥30 appeared to have a higher risk of CKD progression and ... CKD G5D with BMI ≥30 kg/m2 were less likely to receive transplant"
shorturl.at/hoWXj
Prevalence, Characteristics, and Outcomes of People With A High Body Mass Index Across the Kidney Disease Spectrum: A Population-Based Cohort Study - Gurleen Sahi, Jennifer Reid, Louise Moist, Michael...
Background: Obesity has a major impact on health and health care, particularly in those with chronic kidney disease (CKD). Objective: The objective was to descr...
doi.org
November 25, 2024 at 9:09 PM
"Obesity defined by high BMI is highly prevalent in people with CKD, and patients have health, health care, and social disparity"
"...G3-4 with a BMI ≥30 appeared to have a higher risk of CKD progression and ... CKD G5D with BMI ≥30 kg/m2 were less likely to receive transplant"
shorturl.at/hoWXj
"...G3-4 with a BMI ≥30 appeared to have a higher risk of CKD progression and ... CKD G5D with BMI ≥30 kg/m2 were less likely to receive transplant"
shorturl.at/hoWXj
Reposted by Rajib Gupta
The final version of our paper www.nejm.org/doi/10.1056/... One APOL1 risk variant is associated with CKD & FSGS. We have a solid basis for new mechanistic studies in our journey to find durable cure for APOL1 KD @opeyemiolabisi.bsky.social @kidneyomicsamps.bsky.social @genetickidneydoc.bsky.social
November 23, 2024 at 9:11 PM
The final version of our paper www.nejm.org/doi/10.1056/... One APOL1 risk variant is associated with CKD & FSGS. We have a solid basis for new mechanistic studies in our journey to find durable cure for APOL1 KD @opeyemiolabisi.bsky.social @kidneyomicsamps.bsky.social @genetickidneydoc.bsky.social
Reposted by Rajib Gupta
CKD, proteinuria, Crohn's disease. KBx w/focally granulomatous tubulointerstitial nephritis and IgAN. Common findings in IBD patients (pubmed.ncbi.nlm.nih.gov/38344742/). Pt on TNFa inhibitor (pubmed.ncbi.nlm.nih.gov/36706240/) also reported IgAN/TIN associations. #renalpath #pathsky #nephrology.
November 23, 2024 at 12:25 AM
CKD, proteinuria, Crohn's disease. KBx w/focally granulomatous tubulointerstitial nephritis and IgAN. Common findings in IBD patients (pubmed.ncbi.nlm.nih.gov/38344742/). Pt on TNFa inhibitor (pubmed.ncbi.nlm.nih.gov/36706240/) also reported IgAN/TIN associations. #renalpath #pathsky #nephrology.