Patrick Dolan
@ptdolan.bsky.social
Virologist, Evolutionary Biologist, IT guy, PI @ #QVEU
big on mentorship, supporter of scientists.
friendsofthelab.org
Views expressed are my own.
#DC
big on mentorship, supporter of scientists.
friendsofthelab.org
Views expressed are my own.
#DC
Pinned
Patrick Dolan
@ptdolan.bsky.social
· Jun 26
Call for papers - Evolution of disease: From pathogens to proliferating cells
www.biomedcentral.com
Hi #EvoSky #evobio - @biomedcentral.bsky.social BMC #Ecology and #Evolution is currently accepting submissions to a Special Collection “Evolution of disease: From pathogens to proliferating cells”. Please consider submitting your work! Deadline is March 16th. www.biomedcentral.com/collections/...
Reposted by Patrick Dolan
Great to see this exciting perspective by young evolutionary biologists lead by the amazing @mbrasovives.bsky.social out!
Brasó-Vives et al. publish a new Perspective in GBE, highlighting underexplored dimensions of genomic variation that contribute to phenotypic diversity beyond the DNA sequence, contributing to our understanding of genome evolution.
🔗 doi.org/10.1093/gbe/evaf204
#genome #evolution
🔗 doi.org/10.1093/gbe/evaf204
#genome #evolution
November 14, 2025 at 12:21 PM
Great to see this exciting perspective by young evolutionary biologists lead by the amazing @mbrasovives.bsky.social out!
Reposted by Patrick Dolan
My department at UT Austin is looking to hire an Assistant Professor in Evolutionary Biology, broadly defined. Feel free to reach out to me with any questions you may have.
apply.interfolio.com/177547
apply.interfolio.com/177547
Apply - Interfolio
{{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
November 13, 2025 at 3:23 PM
My department at UT Austin is looking to hire an Assistant Professor in Evolutionary Biology, broadly defined. Feel free to reach out to me with any questions you may have.
apply.interfolio.com/177547
apply.interfolio.com/177547
Reposted by Patrick Dolan
📖Latest from the lab:
Evo. characterization #antiviral #SAMD9/9L across #kingdoms🚶♀️🦍🦠🧫🖥️: ancient #convergence + #adaptations @natecoevo.nature.com
Led by amazing Alexandre Legrand +major contributions by Rémi Demeure & Amandine Chantharath @ciri-lyon.bsky.social 1/n
www.nature.com/articles/s41...
Evo. characterization #antiviral #SAMD9/9L across #kingdoms🚶♀️🦍🦠🧫🖥️: ancient #convergence + #adaptations @natecoevo.nature.com
Led by amazing Alexandre Legrand +major contributions by Rémi Demeure & Amandine Chantharath @ciri-lyon.bsky.social 1/n
www.nature.com/articles/s41...
Evolutionary characterization of antiviral SAMD9/9L across kingdoms supports ancient convergence and lineage-specific adaptations - Nature Ecology & Evolution
A search for analogues of the human SAMD9/9L antiviral genes identifies convergent evolution of this gene family in the bacterial and animal kingdoms, with species-specific and recent genomic signatur...
www.nature.com
November 12, 2025 at 5:55 PM
📖Latest from the lab:
Evo. characterization #antiviral #SAMD9/9L across #kingdoms🚶♀️🦍🦠🧫🖥️: ancient #convergence + #adaptations @natecoevo.nature.com
Led by amazing Alexandre Legrand +major contributions by Rémi Demeure & Amandine Chantharath @ciri-lyon.bsky.social 1/n
www.nature.com/articles/s41...
Evo. characterization #antiviral #SAMD9/9L across #kingdoms🚶♀️🦍🦠🧫🖥️: ancient #convergence + #adaptations @natecoevo.nature.com
Led by amazing Alexandre Legrand +major contributions by Rémi Demeure & Amandine Chantharath @ciri-lyon.bsky.social 1/n
www.nature.com/articles/s41...
Reposted by Patrick Dolan
An empirical approach to evaluating the prevalence of long-lived balancing selection in humans--and important limitations. Work by @hannahmm.bsky.social
November 11, 2025 at 7:14 PM
An empirical approach to evaluating the prevalence of long-lived balancing selection in humans--and important limitations. Work by @hannahmm.bsky.social
Reposted by Patrick Dolan
I recently moved my lab to Purdue University and am looking for graduate students. We are working at the interface of population genomics, quantitative genetics and functional genomics to understand how plants adapt to extreme environments. Reach out if you would like to discuss potential projects.
November 8, 2025 at 3:42 PM
I recently moved my lab to Purdue University and am looking for graduate students. We are working at the interface of population genomics, quantitative genetics and functional genomics to understand how plants adapt to extreme environments. Reach out if you would like to discuss potential projects.
Reposted by Patrick Dolan
Conrad Hal Waddington was born OTD in 1905.
His “epigenetic landscape” is a diagrammatic representation of the constraints influencing embryonic development.
On his 50th birthday, his colleagues gave him a pinball machine on the model of the epigenetic landscape.
🧪 🦫🦋 🌱🐋 #HistSTM #philsci #evobio
His “epigenetic landscape” is a diagrammatic representation of the constraints influencing embryonic development.
On his 50th birthday, his colleagues gave him a pinball machine on the model of the epigenetic landscape.
🧪 🦫🦋 🌱🐋 #HistSTM #philsci #evobio
November 8, 2025 at 4:03 PM
Reposted by Patrick Dolan
I want to do this PhD!!
Fantastic opportunity (available for both UK and international students) to do a PhD on the assembly of RNA viruses with @artisplicer.bsky.social - please share (and/or apply)!
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
Funded PhD SWBio DTP- (STANDARD) Genome packaging as a driving force of RNA virus assembly at University of Bristol on FindAPhD.com
PhD Project - Funded PhD SWBio DTP- (STANDARD) Genome packaging as a driving force of RNA virus assembly at University of Bristol, listed on FindAPhD.com
www.findaphd.com
November 7, 2025 at 12:34 PM
I want to do this PhD!!
Reposted by Patrick Dolan
Our new preprint is out 🥳🥳🥳
Henipaviruses, like Nipah and Hendra, package their genomes inside helical shells built by thousands of nucleoproteins. These nucleocapsids are essential to protect the viral RNA, but how do they ever let the polymerase in to read the sequence?
👇
Henipaviruses, like Nipah and Hendra, package their genomes inside helical shells built by thousands of nucleoproteins. These nucleocapsids are essential to protect the viral RNA, but how do they ever let the polymerase in to read the sequence?
👇
November 3, 2025 at 12:26 PM
Our new preprint is out 🥳🥳🥳
Henipaviruses, like Nipah and Hendra, package their genomes inside helical shells built by thousands of nucleoproteins. These nucleocapsids are essential to protect the viral RNA, but how do they ever let the polymerase in to read the sequence?
👇
Henipaviruses, like Nipah and Hendra, package their genomes inside helical shells built by thousands of nucleoproteins. These nucleocapsids are essential to protect the viral RNA, but how do they ever let the polymerase in to read the sequence?
👇
New in ‘Virus Evolution’ from #QVEU! PhD student Jack Dorman used deep mutational scanning to measure evolutionary constraints on the Envelope protein of West Nile Virus in human, mosquito, and bird cell lines, doing a lot of work to put it into a structural context #VirEvol
Constraint in West Nile Virus Envelope Protein across Mosquito, Human, and Avian Host Cell Environments
Abstract. Arthropod-borne viruses are a major cause of global viral infections, displaying evolutionary dynamics that differ significantly from vertebrate-
academic.oup.com
November 1, 2025 at 6:44 PM
National Guard giving out Halloween candy at the U street metro if you are interested!
October 31, 2025 at 1:50 PM
National Guard giving out Halloween candy at the U street metro if you are interested!
Reposted by Patrick Dolan
The Johri Lab has an open postdoc position. Please send me an email, if interested. Start date is flexible. Please do share! Thank you in advance.
October 28, 2025 at 9:31 PM
The Johri Lab has an open postdoc position. Please send me an email, if interested. Start date is flexible. Please do share! Thank you in advance.
Reposted by Patrick Dolan
We are searching for a lab manager!
If you are detailed oriented, like southern california, HSV-1, sequencing and microscopy, please get in touch :)
If you are detailed oriented, like southern california, HSV-1, sequencing and microscopy, please get in touch :)
October 29, 2025 at 12:25 AM
We are searching for a lab manager!
If you are detailed oriented, like southern california, HSV-1, sequencing and microscopy, please get in touch :)
If you are detailed oriented, like southern california, HSV-1, sequencing and microscopy, please get in touch :)
Reposted by Patrick Dolan
🚨 Systems Virology Journal Club – 8th Series! 🚨
#BillSchneider and I are delighted to announce another round of cutting-edge talks in #SystemsVirology! 🦠💡
Join us and an outstanding lineup of speakers, starting Oct 30.
Free registration: shiraweingartengabbay.com/systems-viro... 🔬✨
#BillSchneider and I are delighted to announce another round of cutting-edge talks in #SystemsVirology! 🦠💡
Join us and an outstanding lineup of speakers, starting Oct 30.
Free registration: shiraweingartengabbay.com/systems-viro... 🔬✨
October 20, 2025 at 2:55 PM
🚨 Systems Virology Journal Club – 8th Series! 🚨
#BillSchneider and I are delighted to announce another round of cutting-edge talks in #SystemsVirology! 🦠💡
Join us and an outstanding lineup of speakers, starting Oct 30.
Free registration: shiraweingartengabbay.com/systems-viro... 🔬✨
#BillSchneider and I are delighted to announce another round of cutting-edge talks in #SystemsVirology! 🦠💡
Join us and an outstanding lineup of speakers, starting Oct 30.
Free registration: shiraweingartengabbay.com/systems-viro... 🔬✨
October 17, 2025 at 2:11 AM
Reposted by Patrick Dolan
UMass Amherst Microbiology is hiring a tenure-track virologist. Come work with me! 🦠🧪
careers.umass.edu/amherst/en-u...
careers.umass.edu/amherst/en-u...
Details - Assistant Professor - Virology | Human Resources | UMass Amherst
careers.umass.edu
October 2, 2025 at 2:51 PM
UMass Amherst Microbiology is hiring a tenure-track virologist. Come work with me! 🦠🧪
careers.umass.edu/amherst/en-u...
careers.umass.edu/amherst/en-u...
Reposted by Patrick Dolan
New Cambridge Element in the Philosophy of Biology series—fully #openaccess! @thomasreydon.bsky.social explores how evolutionary theory crosses over from biology into other fields, showing how these crossovers embody a broader style of reasoning: 'evolutionary thinking' bit.ly/48z3h36 #HPbio #evosky
October 3, 2025 at 10:50 AM
New Cambridge Element in the Philosophy of Biology series—fully #openaccess! @thomasreydon.bsky.social explores how evolutionary theory crosses over from biology into other fields, showing how these crossovers embody a broader style of reasoning: 'evolutionary thinking' bit.ly/48z3h36 #HPbio #evosky
New #QVEU preprint! @williambakhache.bsky.social used our #EV71 mutational scanning library to dissect replication complex function with a collection of inhibitors against specific host and viral factors. Then used the data to validate structural predictions! Super cool #virosky #virus #evolution
Genotype-by-Inhibitor Interactions to Dissect Enterovirus Replication
Replication organelles of positive-sense RNA viruses are essential to virus biology, yet their molecular mechanisms remain poorly defined. While deep mutational scanning (DMS) measures the impact of m...
researchsquare.com
September 29, 2025 at 8:13 PM
New #QVEU preprint! @williambakhache.bsky.social used our #EV71 mutational scanning library to dissect replication complex function with a collection of inhibitors against specific host and viral factors. Then used the data to validate structural predictions! Super cool #virosky #virus #evolution
Reposted by Patrick Dolan
🚨 Microbiologists! We are recruiting Assistant / Associate Professors in 3 collaborative areas of our U. Pittsburgh School of Medicine.
1) MMG (my dept): fundamental research in med micro
2) Peds ID / I4Kids institute
3) Center for Vaccine Research
🔗 to all 3 w/info: www.linkedin.com/posts/vaughn...
1) MMG (my dept): fundamental research in med micro
2) Peds ID / I4Kids institute
3) Center for Vaccine Research
🔗 to all 3 w/info: www.linkedin.com/posts/vaughn...
Faculty Professor Associate - Full-Time | Vaughn Cooper
We are recruiting Faculty microbiologists in three (3) different, complementary, and collaborative areas at the University of Pittsburgh associated with the School of Medicine.
1) Fundamental researc...
www.linkedin.com
September 23, 2025 at 10:31 PM
🚨 Microbiologists! We are recruiting Assistant / Associate Professors in 3 collaborative areas of our U. Pittsburgh School of Medicine.
1) MMG (my dept): fundamental research in med micro
2) Peds ID / I4Kids institute
3) Center for Vaccine Research
🔗 to all 3 w/info: www.linkedin.com/posts/vaughn...
1) MMG (my dept): fundamental research in med micro
2) Peds ID / I4Kids institute
3) Center for Vaccine Research
🔗 to all 3 w/info: www.linkedin.com/posts/vaughn...
First ever #QVEU lab “field trip” during group meeting as @orrwalk.bsky.social told us all about his summer research on powdery mildew! Fascinating!
September 19, 2025 at 9:04 PM
First ever #QVEU lab “field trip” during group meeting as @orrwalk.bsky.social told us all about his summer research on powdery mildew! Fascinating!
Reposted by Patrick Dolan
The constant barrage of terrible news on bluesky has made me feel weird about promoting papers, but people in the lab have been doing so much amazing work over the past few months that I want to share a few brief teasers/links:
September 10, 2025 at 4:46 PM
The constant barrage of terrible news on bluesky has made me feel weird about promoting papers, but people in the lab have been doing so much amazing work over the past few months that I want to share a few brief teasers/links:
Reposted by Patrick Dolan
New study! We compared the first two full-proteome Enterovirus DMS datasets and found both shared and unique selection pressures—plus conserved druggable pockets. Great collaboration with @ptdolan.bsky.social ’s team!
dx.doi.org/10.21203/rs....
@bealro.bsky.social @i2sysbio.es
dx.doi.org/10.21203/rs....
@bealro.bsky.social @i2sysbio.es
Comparative Analysis of Deep Mutational Scanning Datasets in Enteroviruses A and B Identifies Functional Divergence and Therapeutic Targets
Deep mutational scanning (DMS) can define functional constraints acting on viral proteomes by quantifying the effects of mutations on viral fitness. However, DMS analyses do not discern type-specific ...
dx.doi.org
September 8, 2025 at 9:30 AM
New study! We compared the first two full-proteome Enterovirus DMS datasets and found both shared and unique selection pressures—plus conserved druggable pockets. Great collaboration with @ptdolan.bsky.social ’s team!
dx.doi.org/10.21203/rs....
@bealro.bsky.social @i2sysbio.es
dx.doi.org/10.21203/rs....
@bealro.bsky.social @i2sysbio.es
Reposted by Patrick Dolan
Congratulations to the great Kanta Subbarao—the unanimous choice of the awards committee to receive the Edward Jenner Award! Nobody is more deserving for her contributions to developing vaccines for bird flu & other emerging respiratory pathogens. #19vaccinecongress
September 8, 2025 at 1:54 AM
Congratulations to the great Kanta Subbarao—the unanimous choice of the awards committee to receive the Edward Jenner Award! Nobody is more deserving for her contributions to developing vaccines for bird flu & other emerging respiratory pathogens. #19vaccinecongress
Reposted by Patrick Dolan
Latest work from our lab from Ashley Della Fera 😀
Chromatin assembly by the histone chaperone HIRA facilitates Human Papillomavirus replication https://www.biorxiv.org/content/10.1101/2025.09.05.674520v1
September 7, 2025 at 12:32 AM
Latest work from our lab from Ashley Della Fera 😀
Reposted by Patrick Dolan
How can we understand the earliest events in evolution of eukaryotic immunity? @yao-li.bsky.social reports incredible molecular fossils of complete bacterial-like operons in eukaryotes that illuminate how animal immunity was first acquired from anti-phage defense
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
September 5, 2025 at 10:13 AM
How can we understand the earliest events in evolution of eukaryotic immunity? @yao-li.bsky.social reports incredible molecular fossils of complete bacterial-like operons in eukaryotes that illuminate how animal immunity was first acquired from anti-phage defense
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Patrick Dolan
Gill, @lemeylab.bsky.social et al. develop Bayesian infinite mixture models for phylogenetic inference, finding that infinite hidden Markov models best capture complex patterns in large datasets; they implement this framework in BEAST X.
🔗 doi.org/10.1093/molbev/msaf199
#evobio #molbio
🔗 doi.org/10.1093/molbev/msaf199
#evobio #molbio
Infinite Mixture Models for Improved Modeling of Across-Site Evolutionary Variation
Abstract. Scientific studies in many areas of biology routinely employ evolutionary analyses based on inference of phylogenetic trees from molecular sequen
doi.org
August 29, 2025 at 9:37 AM
Gill, @lemeylab.bsky.social et al. develop Bayesian infinite mixture models for phylogenetic inference, finding that infinite hidden Markov models best capture complex patterns in large datasets; they implement this framework in BEAST X.
🔗 doi.org/10.1093/molbev/msaf199
#evobio #molbio
🔗 doi.org/10.1093/molbev/msaf199
#evobio #molbio