In summary
- GR is mostly dimeric upon ligand activation
- GR’s final conformation might be a tetramer
- GR-GR contacts depend on a complex, intertwined crosstalk within all structural domains: LBD, DBD, and likely the NTD
- Is transrepression necessary to explain GR action?

By combing X-ray crystallography and live cell studies, Alba and Andrea were able to find new surfaces of GR-GR contacts, suggesting that several types of dimers can coexist in the cell

Back in 2016, we were able to quantify the oligomeric state of GR on a tandem array of DNA elements inside live cells, and we were shocked to find out that GR was actually a tetramer when bound to chromatin!
doi.org/10.1073/pnas...

This paper marks the culmination of a 15-year (and 7 papers) journey to challenge #Glucocorticoid-Receptor(GR) dogma. The classic paradigm of GR action states that monomeric GR and dimeric GR regulate a different set of genes

Thank you for making our review article on the top 20 downloads @commsbio.bsky.social !
Don´t miss the chance to keep growing your endless pdfs folder
www.nature.com/articles/s42...

A must read for parents, educators, politicians, and everyone in between. Highly recommended!

New Preprint!
Multidisplinary approach to unravel the complex quaternary structure of the glucocorticoid receptor.
www.biorxiv.org/content/10.1...

Pre-print Alert! 🚨
Do Glucocorticoid receptor (GR) condensates have a role in transcription?

Check out our latest work in collaboration with Valeria Levi´s lab and talented PhD student Belén Benitez.

doi.org/10.1101/2024...