Pourya Naderi
@pouryany.bsky.social
Comp bio | Networks | Noncoding RNAs | Neurodegeneration. Scientist @HarvardMed. UNCcharlotte Alum.
This is a really cool study. Congratulations
April 4, 2025 at 1:52 AM
This is a really cool study. Congratulations
Many thanks to our funders: National Institute on Aging (NIA), CureAlzheimer's Fund, Beth Israel Deaconess Medical Center.
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January 22, 2025 at 5:46 PM
Many thanks to our funders: National Institute on Aging (NIA), CureAlzheimer's Fund, Beth Israel Deaconess Medical Center.
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Shout out to Carles Boix, Sarah Morgan, Hansruedi Mathys, Dmitry Prokopenko, Bartholomew White, Larisa Soto, Giulia Pegoraro, Saloni Shah, Athanasios Ploumakis, Nikolas Kalavros, David Bennett, Christoph Lange, Doo Yeon Kim, Lars Bertram, Li-Huei Tsai, Manolis Kellis, and Rudolph Tanzi.
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January 22, 2025 at 5:46 PM
Shout out to Carles Boix, Sarah Morgan, Hansruedi Mathys, Dmitry Prokopenko, Bartholomew White, Larisa Soto, Giulia Pegoraro, Saloni Shah, Athanasios Ploumakis, Nikolas Kalavros, David Bennett, Christoph Lange, Doo Yeon Kim, Lars Bertram, Li-Huei Tsai, Manolis Kellis, and Rudolph Tanzi.
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We welcome your comments and feedback!
It really took a village over many years to make this work happen. First and foremost, thanks to Isabel's @isabelscst.bsky.social leadership, persistence, and vision.
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It really took a village over many years to make this work happen. First and foremost, thanks to Isabel's @isabelscst.bsky.social leadership, persistence, and vision.
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January 22, 2025 at 5:46 PM
We welcome your comments and feedback!
It really took a village over many years to make this work happen. First and foremost, thanks to Isabel's @isabelscst.bsky.social leadership, persistence, and vision.
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It really took a village over many years to make this work happen. First and foremost, thanks to Isabel's @isabelscst.bsky.social leadership, persistence, and vision.
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we found a population of MEF2C+ATP8B1+RELN+ excitatory neurons with increased proportions in resilience and significant depletion in AD. In resilient subjects, these neurons uniquely maintained cellular communication with neurons through neurotrophin and angiopoietin signaling pathways.
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January 22, 2025 at 5:46 PM
we found a population of MEF2C+ATP8B1+RELN+ excitatory neurons with increased proportions in resilience and significant depletion in AD. In resilient subjects, these neurons uniquely maintained cellular communication with neurons through neurotrophin and angiopoietin signaling pathways.
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Distinct roles for excitatory and inhibitory neurons in resilience/resistance: Using a snRNA seq cohort of AD brains and leveraging genes associated with rare genetic variants of AD, we found subtypes of somatostatin+ inhibitory neurons to be associated with resistance and vulnerability to AD.
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January 22, 2025 at 5:46 PM
Distinct roles for excitatory and inhibitory neurons in resilience/resistance: Using a snRNA seq cohort of AD brains and leveraging genes associated with rare genetic variants of AD, we found subtypes of somatostatin+ inhibitory neurons to be associated with resistance and vulnerability to AD.
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Most of the tissue level changes of gene expression were observed between AD and resilience and were concordantly dysregulated between AD vs healthy. Comparison of AD polygenic risk scores confirmed resilience as an intermediate stage between AD and healthy conditions.
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January 22, 2025 at 5:46 PM
Most of the tissue level changes of gene expression were observed between AD and resilience and were concordantly dysregulated between AD vs healthy. Comparison of AD polygenic risk scores confirmed resilience as an intermediate stage between AD and healthy conditions.
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Resilience is a sustained presymptomatic stage of AD rather than a distinct trajectory. Surprisingly, only two genes showed differential expression between resilience and healthy subjects in a post-mortem brain autopsy cohort: GFAP and KLF4.
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January 22, 2025 at 5:46 PM
Resilience is a sustained presymptomatic stage of AD rather than a distinct trajectory. Surprisingly, only two genes showed differential expression between resilience and healthy subjects in a post-mortem brain autopsy cohort: GFAP and KLF4.
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What we found was distinct roles for excitatory and inhibitory neurons in resilience and resistance to AD.
Some of our findings👇
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Some of our findings👇
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January 22, 2025 at 5:46 PM
What we found was distinct roles for excitatory and inhibitory neurons in resilience and resistance to AD.
Some of our findings👇
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Some of our findings👇
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We asked how brain cell populations and their distinct molecular functions contribute to describing resilience. We integrated evidence from bulk RNA sequencing, rare variant genetics, single-nuclei RNA seq, and immunofluorescent imaging.
#RNASeq #SingleCell
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#RNASeq #SingleCell
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January 22, 2025 at 5:46 PM
We asked how brain cell populations and their distinct molecular functions contribute to describing resilience. We integrated evidence from bulk RNA sequencing, rare variant genetics, single-nuclei RNA seq, and immunofluorescent imaging.
#RNASeq #SingleCell
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#RNASeq #SingleCell
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Many aged individuals show resilience to AD by maintaining healthy cognition despite having advanced AD pathology. Understanding the biological mechanisms of resilience could lead to the development of much-needed new approaches to combat the disease.
#AlzheimersResearch #Bioinformatics
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#AlzheimersResearch #Bioinformatics
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January 22, 2025 at 5:46 PM
Many aged individuals show resilience to AD by maintaining healthy cognition despite having advanced AD pathology. Understanding the biological mechanisms of resilience could lead to the development of much-needed new approaches to combat the disease.
#AlzheimersResearch #Bioinformatics
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#AlzheimersResearch #Bioinformatics
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