Janne Pott
@pottj.bsky.social
Interested in genetics, statistics, Mendelian Randomization, and hormones.
Postdoc at MRC BSU.
Open water swimming in my free time.
Postdoc at MRC BSU.
Open water swimming in my free time.
Could this be a survival data problem? Harzard ratio are hazardous (check pmc.ncbi.nlm.nih.gov/articles/PMC... ). Could this be a MR problem (life course effect vs specific effect in cancer patients)? Let me know if you have any thoughts on this!
The Hazards of Hazard Ratios
pmc.ncbi.nlm.nih.gov
October 6, 2025 at 4:50 PM
Could this be a survival data problem? Harzard ratio are hazardous (check pmc.ncbi.nlm.nih.gov/articles/PMC... ). Could this be a MR problem (life course effect vs specific effect in cancer patients)? Let me know if you have any thoughts on this!
First, the reported SNP failed to associate in independent data sets, then the MR with genetically proxied PCSK9 levels was not significant. Finally, we tried MVMR to correct for potential influence from lipids, but still observed no effect.
October 6, 2025 at 4:50 PM
First, the reported SNP failed to associate in independent data sets, then the MR with genetically proxied PCSK9 levels was not significant. Finally, we tried MVMR to correct for potential influence from lipids, but still observed no effect.
We also compare fixing taxon traceability to the gold standard, phylogenetic decisiveness. Thanks to my master thesis supervisor Mareike Fischer for continuing on this project, keeping me in on it, and especially for proving the bounds!
June 10, 2025 at 8:10 PM
We also compare fixing taxon traceability to the gold standard, phylogenetic decisiveness. Thanks to my master thesis supervisor Mareike Fischer for continuing on this project, keeping me in on it, and especially for proving the bounds!
We provide here an algorithm (implemented in R, package available at github.com/pottj/Fixing...) and some bounds for this nice set of taxon sets.
GitHub - pottj/FixingTaxonTraceR: Check sets of taxon sets for fixing taxon traceability (FTT), a special case of phylogenetic decisiveness
Check sets of taxon sets for fixing taxon traceability (FTT), a special case of phylogenetic decisiveness - pottj/FixingTaxonTraceR
github.com
June 10, 2025 at 8:10 PM
We provide here an algorithm (implemented in R, package available at github.com/pottj/Fixing...) and some bounds for this nice set of taxon sets.
Fixing taxon traceability (simplified): assume n taxa and k sets of quadruples defining a tree each. Then the set of k quadruples is fixing taxon traceable if all missing quadruples have a fixing taxon or can be resolved using the input quadruples + those with fixing taxa.
June 10, 2025 at 8:10 PM
Fixing taxon traceability (simplified): assume n taxa and k sets of quadruples defining a tree each. Then the set of k quadruples is fixing taxon traceable if all missing quadruples have a fixing taxon or can be resolved using the input quadruples + those with fixing taxa.
Fixing taxon: assume 5 taxa and only 4 of 5 possible trees available. Then one taxon is in all trees (e.g. taxon 3 in the quartet trees on the left, combination of Figure 1, 2, and 4 of the publication), the supertree is already defined (tree on the right), and hence the "missing" tree too!
June 10, 2025 at 8:10 PM
Fixing taxon: assume 5 taxa and only 4 of 5 possible trees available. Then one taxon is in all trees (e.g. taxon 3 in the quartet trees on the left, combination of Figure 1, 2, and 4 of the publication), the supertree is already defined (tree on the right), and hence the "missing" tree too!