Pierre Maisonneuve
@pierre-maisonneuve.bsky.social
Structural biologist in human signaling and pseudokinase aficionados. Group leader IECB, CBMN, CNRS Researcher, University of Bordeaux
Pinned
BRAF oncogenic mutants evade autoinhibition through a common mechanism
Uncontrolled activation of the rat sarcoma (RAS)–extracellular signal–regulated kinase (ERK) pathway drives tumor growth, often because of oncogenic BRAF mutations. BRAF regulation, involving monomeri...
www.science.org
🎉 New paper out in Science!
In collaboration with Marc Therrien’s lab, we show how oncogenic BRAF mutants adopt a pre-active conformation, escaping auto-inhibition and driving RAS–ERK pathway activation in cancer.
Proud to have contributed! #IRIC #CBMN @iecb.bsky.social @univbordeaux.bsky.social
In collaboration with Marc Therrien’s lab, we show how oncogenic BRAF mutants adopt a pre-active conformation, escaping auto-inhibition and driving RAS–ERK pathway activation in cancer.
Proud to have contributed! #IRIC #CBMN @iecb.bsky.social @univbordeaux.bsky.social
Reposted by Pierre Maisonneuve
We have a fully funded studentship to start your PhD in October 2026! Work with me, Elton Zeqiraj and Joe Cockburn to find new ways to treat diseases with high levels of Hedgehog signalling. Fantastic training in cell and structural biology, genomic screening and biochemistry at the Uni of Leeds!
Stopping GLI transcription factors in their tracks: identifying regulators of proteolysis as therapeutic targets. at University of Leeds on FindAPhD.com
PhD Project - Stopping GLI transcription factors in their tracks: identifying regulators of proteolysis as therapeutic targets. at University of Leeds, listed on FindAPhD.com
www.findaphd.com
November 10, 2025 at 10:11 AM
We have a fully funded studentship to start your PhD in October 2026! Work with me, Elton Zeqiraj and Joe Cockburn to find new ways to treat diseases with high levels of Hedgehog signalling. Fantastic training in cell and structural biology, genomic screening and biochemistry at the Uni of Leeds!
Reposted by Pierre Maisonneuve
This one is a bit of a departure from the usual and definitely a work in progress!
We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.
Read on for details... 1/x
We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.
Read on for details... 1/x
September 13, 2025 at 12:05 AM
This one is a bit of a departure from the usual and definitely a work in progress!
We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.
Read on for details... 1/x
We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.
Read on for details... 1/x
Reposted by Pierre Maisonneuve
🔬 Braf : le verrou moléculaire que les cellules cancéreuses peuvent forcer - Une équipe internationale, dont des scientifiques bordelais du CBMN*, explorent une piste prometteuse pour entraver ces cellules cancéreuses :
Braf : le verrou moléculaire que les cellules cancéreuses peuvent forcer | CNRS Chimie
Des scientifiques ont percé le secret de mutations génétiques communes à de nombreux cancers qui activent de manière anarchique une protéine-clé de la d
www.inc.cnrs.fr
September 4, 2025 at 10:30 AM
🔬 Braf : le verrou moléculaire que les cellules cancéreuses peuvent forcer - Une équipe internationale, dont des scientifiques bordelais du CBMN*, explorent une piste prometteuse pour entraver ces cellules cancéreuses :
Reposted by Pierre Maisonneuve
Flying start to the #iubmbkinases meeting in beautiful Queenstown, NZ. Jubilee Award from IUBMB to Kevan Shokat yesterday, and a kinase masterclass from Susan Taylor this morning
August 18, 2025 at 9:16 PM
Flying start to the #iubmbkinases meeting in beautiful Queenstown, NZ. Jubilee Award from IUBMB to Kevan Shokat yesterday, and a kinase masterclass from Susan Taylor this morning
Reposted by Pierre Maisonneuve
New research in Science greatly expands the potential target scope of molecular glues and should stimulate the development of new small molecules that can selectively target therapeutically relevant proteins for degradation.
Learn more in this week's issue: scim.ag/44uRorm
Learn more in this week's issue: scim.ag/44uRorm
July 3, 2025 at 6:05 PM
New research in Science greatly expands the potential target scope of molecular glues and should stimulate the development of new small molecules that can selectively target therapeutically relevant proteins for degradation.
Learn more in this week's issue: scim.ag/44uRorm
Learn more in this week's issue: scim.ag/44uRorm
🚨 Fully funded PhD position in plant & structural biology! Join the @eliastahl.bsky.social lab in collaboration with our team. Exciting project on protein structure/function in plants 🌱. Contact us for details!
#PlantBiology #StructuralBiology #PhDposition @iecb.bsky.social
#PlantBiology #StructuralBiology #PhDposition @iecb.bsky.social
We are recruiting!
A three year PhD position @iecb.bsky.social and @lbm-bordeaux.bsky.social to study lipid recognition by plant receptor-like kinases. A collaborative project with the team of @pierre-maisonneuve.bsky.social. Join us in the beautiful city of Bordeaux!
emploi.cnrs.fr/Offres/Docto...
A three year PhD position @iecb.bsky.social and @lbm-bordeaux.bsky.social to study lipid recognition by plant receptor-like kinases. A collaborative project with the team of @pierre-maisonneuve.bsky.social. Join us in the beautiful city of Bordeaux!
emploi.cnrs.fr/Offres/Docto...
June 19, 2025 at 7:10 AM
🚨 Fully funded PhD position in plant & structural biology! Join the @eliastahl.bsky.social lab in collaboration with our team. Exciting project on protein structure/function in plants 🌱. Contact us for details!
#PlantBiology #StructuralBiology #PhDposition @iecb.bsky.social
#PlantBiology #StructuralBiology #PhDposition @iecb.bsky.social
Reposted by Pierre Maisonneuve
Fascinating and diverse programme of talks at the joint Autophagy UK and @ukproteostasis.bsky.social meeting in Dundee this week! & super happy to have the chance share our #pseudoligase work 📣
June 6, 2025 at 12:12 PM
Fascinating and diverse programme of talks at the joint Autophagy UK and @ukproteostasis.bsky.social meeting in Dundee this week! & super happy to have the chance share our #pseudoligase work 📣
🎉 New paper out in Science!
In collaboration with Marc Therrien’s lab, we show how oncogenic BRAF mutants adopt a pre-active conformation, escaping auto-inhibition and driving RAS–ERK pathway activation in cancer.
Proud to have contributed! #IRIC #CBMN @iecb.bsky.social @univbordeaux.bsky.social
In collaboration with Marc Therrien’s lab, we show how oncogenic BRAF mutants adopt a pre-active conformation, escaping auto-inhibition and driving RAS–ERK pathway activation in cancer.
Proud to have contributed! #IRIC #CBMN @iecb.bsky.social @univbordeaux.bsky.social
BRAF oncogenic mutants evade autoinhibition through a common mechanism
Uncontrolled activation of the rat sarcoma (RAS)–extracellular signal–regulated kinase (ERK) pathway drives tumor growth, often because of oncogenic BRAF mutations. BRAF regulation, involving monomeri...
www.science.org
May 30, 2025 at 5:09 PM
🎉 New paper out in Science!
In collaboration with Marc Therrien’s lab, we show how oncogenic BRAF mutants adopt a pre-active conformation, escaping auto-inhibition and driving RAS–ERK pathway activation in cancer.
Proud to have contributed! #IRIC #CBMN @iecb.bsky.social @univbordeaux.bsky.social
In collaboration with Marc Therrien’s lab, we show how oncogenic BRAF mutants adopt a pre-active conformation, escaping auto-inhibition and driving RAS–ERK pathway activation in cancer.
Proud to have contributed! #IRIC #CBMN @iecb.bsky.social @univbordeaux.bsky.social
Reposted by Pierre Maisonneuve
With less than a month to submit abstracts for the
@iubmb.bsky.social Focussed Meeting on (pseudo)Kinases in stunning Queenstown, we are delighted to announce travel scholarships for selected ECRs thanks to @biologists.bsky.social and the Maurice and Phyllis Trust! www.ivvy.com.au/event/IUBMB25/
@iubmb.bsky.social Focussed Meeting on (pseudo)Kinases in stunning Queenstown, we are delighted to announce travel scholarships for selected ECRs thanks to @biologists.bsky.social and the Maurice and Phyllis Trust! www.ivvy.com.au/event/IUBMB25/
May 23, 2025 at 8:34 AM
With less than a month to submit abstracts for the
@iubmb.bsky.social Focussed Meeting on (pseudo)Kinases in stunning Queenstown, we are delighted to announce travel scholarships for selected ECRs thanks to @biologists.bsky.social and the Maurice and Phyllis Trust! www.ivvy.com.au/event/IUBMB25/
@iubmb.bsky.social Focussed Meeting on (pseudo)Kinases in stunning Queenstown, we are delighted to announce travel scholarships for selected ECRs thanks to @biologists.bsky.social and the Maurice and Phyllis Trust! www.ivvy.com.au/event/IUBMB25/
Reposted by Pierre Maisonneuve
We are recruiting 🤩🤩🤩!!! If you are looking to establish ylur lab in a multidisciplinary institute with state-of-the-art facilities, horizontal structure and diverse faculty, apply!!!
April 14, 2025 at 8:57 AM
We are recruiting 🤩🤩🤩!!! If you are looking to establish ylur lab in a multidisciplinary institute with state-of-the-art facilities, horizontal structure and diverse faculty, apply!!!
Reposted by Pierre Maisonneuve
A few more days to apply for postdoctoral positions in my group. We investigate :
- tau amyloid formation at a molecular level
- tau LLPS
- tau-spliceosome interaction in tauopathies.
More info here : www.fichou-lab.cnrs.fr/en/home
- tau amyloid formation at a molecular level
- tau LLPS
- tau-spliceosome interaction in tauopathies.
More info here : www.fichou-lab.cnrs.fr/en/home
Home - Yann Fichou
The Fichou Lab focuses on the molecular mechanisms underlying neurodegenerative diseases.
www.fichou-lab.cnrs.fr
March 26, 2025 at 6:31 PM
A few more days to apply for postdoctoral positions in my group. We investigate :
- tau amyloid formation at a molecular level
- tau LLPS
- tau-spliceosome interaction in tauopathies.
More info here : www.fichou-lab.cnrs.fr/en/home
- tau amyloid formation at a molecular level
- tau LLPS
- tau-spliceosome interaction in tauopathies.
More info here : www.fichou-lab.cnrs.fr/en/home
Reposted by Pierre Maisonneuve
Reminder - still one month to apply to be a tenure track group leader at MRC LMB. Please do reach out for any information.
Come and joint us at @mrclmb.bsky.social ! We have an opening for a new group leader in the Structural Studies Division. We are very interactive and collaborative with amazing facilities and generous core funding. Get in touch with myself or @sjorsscheres.bsky.social if you have any questions.
Join our Structural Studies Division, leading a research group developing computational methods to address questions in molecular & cellular biology!
You will be supported by core funding, excellent facilities & enthusiastic colleagues.
Apply by 18 MAR
www.nature.com/naturecareer...
You will be supported by core funding, excellent facilities & enthusiastic colleagues.
Apply by 18 MAR
www.nature.com/naturecareer...
February 22, 2025 at 9:50 AM
Reminder - still one month to apply to be a tenure track group leader at MRC LMB. Please do reach out for any information.
(1/4) 🚀 PhD Fellowship Opportunity @iecb.bsky.social @univbordeaux.bsky.social University of Bordeaux!
Looking for talented international Master’s graduates to apply for a PhD fellowship via the UB PhD Scholarship.
Two exciting projects in kinase biology & nanobody therapeutics! ⬇️ Please Repost
Looking for talented international Master’s graduates to apply for a PhD fellowship via the UB PhD Scholarship.
Two exciting projects in kinase biology & nanobody therapeutics! ⬇️ Please Repost
February 14, 2025 at 2:29 PM
(1/4) 🚀 PhD Fellowship Opportunity @iecb.bsky.social @univbordeaux.bsky.social University of Bordeaux!
Looking for talented international Master’s graduates to apply for a PhD fellowship via the UB PhD Scholarship.
Two exciting projects in kinase biology & nanobody therapeutics! ⬇️ Please Repost
Looking for talented international Master’s graduates to apply for a PhD fellowship via the UB PhD Scholarship.
Two exciting projects in kinase biology & nanobody therapeutics! ⬇️ Please Repost
Reposted by Pierre Maisonneuve
Join us next week on Friday the 7th, at 11 am, in our IECB amphitheater to learn a whole lot on the design and applications of enzyme cascades for organic synthesis 🤓🧪👩🔬⚗️! Guest speaker Prof. Sabine Flitsch from the University of Manchester 🤩!!!
www.iecb.u-bordeaux.fr/evenements/i...
www.iecb.u-bordeaux.fr/evenements/i...
January 28, 2025 at 2:00 PM
Join us next week on Friday the 7th, at 11 am, in our IECB amphitheater to learn a whole lot on the design and applications of enzyme cascades for organic synthesis 🤓🧪👩🔬⚗️! Guest speaker Prof. Sabine Flitsch from the University of Manchester 🤩!!!
www.iecb.u-bordeaux.fr/evenements/i...
www.iecb.u-bordeaux.fr/evenements/i...
Looking forward to be there! The list of speakers is impressive. So proud to be part of it.
Exciting to open registration for the IUBMB Focussed Meeting on Emerging roles of (pseudo)kinases! Fantastic speakers in an unmatched location, lots of speaking slots available for ECRS.
Interested in kinases or pseudokinases? We would love to see you in Queenstown!
www.ivvy.com.au/event/IUBMB2...
Interested in kinases or pseudokinases? We would love to see you in Queenstown!
www.ivvy.com.au/event/IUBMB2...
January 29, 2025 at 7:19 AM
Looking forward to be there! The list of speakers is impressive. So proud to be part of it.