9/n
Huge thanks to the team: Innah, Bibek @ogsurgery.bsky.social, @hannagroupicl.bsky.social

@imperialsandc.bsky.social @imperialmed.bsky.social @imperialcollegeldn.bsky.social

Read the full open access study here: www.nature.com/articles/s41...

Double celebration day: PhD graduation + paper🥂

7/n
To validate, we oxidised lipid standards → VOCs were only generated from unsaturated lipids, and traceable back to double bond breakages in fatty acids.

Multi-omics integration (DIABLO) revealed strong VOC–lipid correlations (r > 0.7).

6/n
What we found:
Resistant cells released unique VOCs post-treatment:
Alkenes, Aldehydes (e.g. hexanal, nonanal), short chain fatty acids (e.g. nonanoic, 5-octenoic acid)

These VOCs correlated with lipid species rich in oleic, linoleic, and arachidonic acid.

5/n
What we did:

mTORi-sensitive and -resistant CRC cell lines
Treated with OSI-027/AZD2014
Paired untargeted LC-MS lipidomics + GC-MS volatilomics

Turns out I still haven’t had enough of #VOCs — a BSc and a PhD later — and I’m sticking around for more science as a post-doc in the @hannagroupicl.bsky.social at @imperialcollegeldn.bsky.social

🎉Last big to-do for 2024 checked off! #PhD thesis successfully defended.

✅ Dr. Philip Leung, PhD FHEA

It’s been an enjoyable and intellectually stimulating 3-year journey working with @hannagroupicl.bsky.social and @dr--stef.bsky.social🙌

@imperialsandc.bsky.social
@imperialmed.bsky.social