Vincent Pasque
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pasquelab.bsky.social
Vincent Pasque
@pasquelab.bsky.social
1.1K followers 440 following 58 posts
Stem cell and developmental biologist, Professor @ University of Leuven, Belgium. #Pluripotency #Epigenetics
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pasquelab.bsky.social
Thank you, John, for lifting up everyone around you.
October 8, 2025 at 8:40 AM
pasquelab.bsky.social
Congratulations to the Joanna Wysocka lab for their outstanding work that inspired this piece.
#blastoids #stemcells #KULeuven @kuleuvenuniversity.bsky.social
October 1, 2025 at 3:37 PM
pasquelab.bsky.social
www.nature.com/articles/s41...
X-chromosome upregulation operates on a gene-by-gene basis at RNA and protein levels - Nature Communications
Here, the authors investigate gene dosage compensation in mouse pluripotent stem cells to better understand the process of X-chromosome upregulation. They report that mammalian cells can sense when segments of one of the two X chromosomes are genetically deleted in cis and compensate gene expression by upregulation in trans.
www.nature.com
September 30, 2025 at 9:50 AM
pasquelab.bsky.social
On a personal note, I feel privileged to have collaborated with her. Her passion and insight continue to motivate us.

Here’s a paper we worked on together - a small part of her big impact: www.nature.com/articles/s41...

Janet, this award is well deserved. Congratulations!
Evaluating totipotency using criteria of increasing stringency - Nature Cell Biology
Posfai, Schell, Janiszewski et al. assess candidate totipotent stem cells with in vitro and in vivo assays of increasing stringency to evaluate their developmental potential and lineage contributions.
www.nature.com
June 3, 2025 at 4:44 PM