Pascal Geldsetzer
pascalge.bsky.social
Pascal Geldsetzer
@pascalge.bsky.social
Assistant Professor of Medicine and, by courtesy, of Epidemiology and Population Health, Stanford University;
CZ Biohub – San Francisco investigator

https://profiles.stanford.edu/pascal-geldsetzer
@PGeldsetzer1 on X/Twitter
April 2, 2025 at 5:15 PM
What’s next? We want to run a randomized clinical trial. This relies on philanthropy because we want to trial a version of the old shingles vaccine (that’s what we’ve all the evidence for!), which is no longer being manufactured. Reach out if you want to help fund!
April 2, 2025 at 5:15 PM
We see the same protective effect in dataset after dataset from different countries that rolled out the shingles vaccine in similar ways --> this can’t just be a chance finding!
April 2, 2025 at 5:15 PM
Other studies have all compared people who go get vaccinated to those who don’t --> these are folk with very different health behaviors. So, what you get then is much more likely to be biased.
April 2, 2025 at 5:15 PM
You take 1,000 people born one week and 1,000 born just a week later --> no reason to think that they should differ in their health behaviors 🏃‍♀️🧑‍🍳. So, we have beauuutiful comparison groups. This is an opportunity to get at cause and effect!
April 2, 2025 at 5:15 PM
What’s so special about our study? In Wales, if your 80th birthday was just b4 the start date of the shingles vax program, you were ineligible. If it was just after, you could get the shot. Just a week’s difference in age means your chances of getting vaxxed jump from 0 to 50%!
April 2, 2025 at 5:15 PM