PainScience.com (Paul Ingraham)
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painsci.bsky.social
PainScience.com (Paul Ingraham)
@painsci.bsky.social
Highlights and skeptical snark about the science of chronic pain and injury rehab, from PainScience.com publisher Paul Ingraham. + Digressions into astronomy, Roman history, palaeontology, more. Everything is too interesting to focus!
I phrased that poorly. What I meant was not that the moon is continuously very close throughout the entire month, but rather that it remains relatively close for several days before and after being full at perigee ("supermoon")…and it will do that yet again next month, for the third month in a row.
November 11, 2025 at 8:47 PM
Moon comparison image by Şenol Şanlı: www.instagram.com/snlsanli/

As showcased recently by APOD:

www.star.ucl.ac.uk/~apod/apod/a...

APOD unavailable at its NASA.gov since the shutdown…but you can still get it from mirror sites, still posting. All the mirror URLs:

apod.nasa.gov/apod/lib/abo...
November 11, 2025 at 6:38 PM
I’ve been intending to write about this topic for about 20 years now. I think I’ve been procrastinating as I tried to figure out what how to say what I wanted to say! 😜
November 8, 2025 at 8:10 PM
The post is a 4-minute read. TL;DR:

Isn't it good to relieve suffering? Yes! Are they really different? They are, but they have a very close working relationship. Why does this matter? Conflating them is bad for care!
November 8, 2025 at 7:33 PM
… after injuring their sciatic nerves, far away in the hip! …

And the mapping showed a shift in activity over a month from the motor cortex to the hypothalamus, which sheds some light on how pain becomes chronic.

This is my 1st take, with no commentary on cromulence.
November 4, 2025 at 9:09 PM
So microglia are the immune cells of the central nervous system, and they shape-change depending on their activity.

When provoked by injury, infection, or stress, they get amoeboid, thickened, and mobile.

This study mapped where these changes happened in the BRAINS of rats …
November 4, 2025 at 9:09 PM
I also used a 10 sec shutter delay to give it plenty of time to stop jiggling after the last touch. I took 100s of moon photos in the last month before realizing this — but now that I’ve seen it, I can't un-see it. 😜 At 60×, that thing is DANCING for several seconds before settling down.
October 30, 2025 at 8:07 PM
(And yet think about how many things are “prescribed” for pain that are essentially just … pleasant!)
October 30, 2025 at 3:49 PM
This one goes to dork-factor 9. If you’re not interested in the details, there's a plain English intro and conclusion. But the details are the POINT. If you followed because you want to learn how to think about the science of pain, this is what you signed up for. 🙂
October 27, 2025 at 8:34 PM
I wrote an article loooong that hypothesizes about links between respiration and pain. It’s an oddball in my library, though! At odds with my own modern skepticism. Probably doesn't really hold up. But I haven't taken it down either. 😜

www.painscience.com/respiration_...
Breathing Inefficiently Can Cause Pain
How dysfunctional breathing might be a root cause of a variety of common upper body pain problems and injuries.
www.painscience.com
October 27, 2025 at 5:12 PM
Sorry for a slow reaction—too many full inboxes! I’ve covered posturology (etc) a lot over the years and I'm generally extremely skeptical:

www.painscience.com/posture

But I don’t know much about PRI specifically. 🤷🏻‍♂️ Glad you got some relief, though, however it happened!
Does Posture Matter? A deep dive
Everything there is to know about postural correction—and especially why it doesn’t matter very much. Heavily referenced.
www.painscience.com
October 24, 2025 at 6:52 PM
You'll have to tell me what "PRI" is I’m afraid. As plugged in as I am to the world of physical/pain medicine … there are literally THOUSANDS of acronyms and named treatment ideas in this business (and new ones all the time).
October 22, 2025 at 6:45 PM
Long-term chronic pain is where a lot of my professional focus is, and personal too. I am also a chronic pain patient:

tryeverything.substack.com/p/its-like-l...
It’s like Long COVID
Living with a Long-COVID-ish illness since way before COVID
tryeverything.substack.com
October 22, 2025 at 6:44 PM
VR? Literally immersive?
October 22, 2025 at 12:36 AM
Indeed. It is … immersive.
October 22, 2025 at 12:29 AM
🤣

I occasionally a publish personal stuff that has nothing to do with pain.

OR DOES IT?!
October 22, 2025 at 12:26 AM