Pacific Optica
@pacificoptica.bsky.social
Optics for multiphoton imaging, laser scanning, and more. Based in Santa Barbara, California. pacificoptica.com
Happy Halloween!
pacificoptica.com/cousa/
pacificoptica.com/cousa/
October 31, 2025 at 1:34 AM
Happy Halloween!
pacificoptica.com/cousa/
pacificoptica.com/cousa/
Check out some sweet Ventana Wide + Cousa imaging.
pacificoptica.com/ventana/
Live raw data over a 3.2 mm wide field-of-view with 16,000 lines/s scanning and submicron resolution. Demo now at @omibs-mbl.bsky.social
Thx @ewadorotaz.bsky.social @mbfbioscience.bsky.social @crisrodtsou.bsky.social !
pacificoptica.com/ventana/
Live raw data over a 3.2 mm wide field-of-view with 16,000 lines/s scanning and submicron resolution. Demo now at @omibs-mbl.bsky.social
Thx @ewadorotaz.bsky.social @mbfbioscience.bsky.social @crisrodtsou.bsky.social !
August 20, 2025 at 1:46 AM
Check out some sweet Ventana Wide + Cousa imaging.
pacificoptica.com/ventana/
Live raw data over a 3.2 mm wide field-of-view with 16,000 lines/s scanning and submicron resolution. Demo now at @omibs-mbl.bsky.social
Thx @ewadorotaz.bsky.social @mbfbioscience.bsky.social @crisrodtsou.bsky.social !
pacificoptica.com/ventana/
Live raw data over a 3.2 mm wide field-of-view with 16,000 lines/s scanning and submicron resolution. Demo now at @omibs-mbl.bsky.social
Thx @ewadorotaz.bsky.social @mbfbioscience.bsky.social @crisrodtsou.bsky.social !
Scientists explore, measure, gather evidence, figure things out, and share openly. Their work benefits us all.
Demo imaging at MBL/Woods Hole and CSHL this summer. Explore further. pacificoptica.com
Demo imaging at MBL/Woods Hole and CSHL this summer. Explore further. pacificoptica.com
August 14, 2025 at 12:32 AM
Scientists explore, measure, gather evidence, figure things out, and share openly. Their work benefits us all.
Demo imaging at MBL/Woods Hole and CSHL this summer. Explore further. pacificoptica.com
Demo imaging at MBL/Woods Hole and CSHL this summer. Explore further. pacificoptica.com
Put whatever objective you want on the Ventana Wide. It will give you the largest field of view with high speed scanning: eg, 3.2mm x 3.2mm with a 10x. Fast, flexible 2p imaging.
Che-Hang Yu is helping MBL courses with this Ventana Wide system pacificoptica.com/ventana/
Che-Hang Yu is helping MBL courses with this Ventana Wide system pacificoptica.com/ventana/
August 2, 2025 at 7:40 AM
Put whatever objective you want on the Ventana Wide. It will give you the largest field of view with high speed scanning: eg, 3.2mm x 3.2mm with a 10x. Fast, flexible 2p imaging.
Che-Hang Yu is helping MBL courses with this Ventana Wide system pacificoptica.com/ventana/
Che-Hang Yu is helping MBL courses with this Ventana Wide system pacificoptica.com/ventana/
Just landed in Woods Hole for summer courses: a Full Ventana Wide system. pacificoptica.com/ventana/ with a Cousa pacificoptica.com/cousa/
www.mbl.edu/education/ad...
www.mbl.edu/education/ad...
Thanks, Coherent! Thanks, MBF! Thanks to course leadership and MBL staff!
www.mbl.edu/education/ad...
www.mbl.edu/education/ad...
Thanks, Coherent! Thanks, MBF! Thanks to course leadership and MBL staff!
August 2, 2025 at 4:53 AM
Just landed in Woods Hole for summer courses: a Full Ventana Wide system. pacificoptica.com/ventana/ with a Cousa pacificoptica.com/cousa/
www.mbl.edu/education/ad...
www.mbl.edu/education/ad...
Thanks, Coherent! Thanks, MBF! Thanks to course leadership and MBL staff!
www.mbl.edu/education/ad...
www.mbl.edu/education/ad...
Thanks, Coherent! Thanks, MBF! Thanks to course leadership and MBL staff!
Widespread cortical representations of innate behaviors in the mouse. www.biorxiv.org/content/10.1... Using the Diesel2p pacificoptica.com/diesel2p/, they found that "more directed and unilateral grooming movements had greater cortical associated responses than more
stereotyped bilateral movements"
stereotyped bilateral movements"
July 30, 2025 at 6:21 AM
Widespread cortical representations of innate behaviors in the mouse. www.biorxiv.org/content/10.1... Using the Diesel2p pacificoptica.com/diesel2p/, they found that "more directed and unilateral grooming movements had greater cortical associated responses than more
stereotyped bilateral movements"
stereotyped bilateral movements"
No more stitching artifacts. Just image the whole field-of-view, at high resolution, in one pass. The Ventana systems give submicron resolution over huge fields-of-view almost 10 square mm. At high speed. Cover a 3.2 mm x 3.2 mm area in 4k resolution in 0.26 s. pacificoptica.com/ventana/
July 14, 2025 at 1:16 AM
No more stitching artifacts. Just image the whole field-of-view, at high resolution, in one pass. The Ventana systems give submicron resolution over huge fields-of-view almost 10 square mm. At high speed. Cover a 3.2 mm x 3.2 mm area in 4k resolution in 0.26 s. pacificoptica.com/ventana/
Explore further. pacificoptica.com/diesel2p/
July 13, 2025 at 9:04 AM
Explore further. pacificoptica.com/diesel2p/
Animals sense in complex environments, and neuronal responses to olfactory/scent stimuli can be shaped by recent history going back ~ 30 s. Here, Subramanian, Storace, et al. used the Cousa objective pacificoptica.com/cousa/ to neural activity in vivo. doi.org/10.1093/chem... #microscopymonday
June 23, 2025 at 5:57 PM
Animals sense in complex environments, and neuronal responses to olfactory/scent stimuli can be shaped by recent history going back ~ 30 s. Here, Subramanian, Storace, et al. used the Cousa objective pacificoptica.com/cousa/ to neural activity in vivo. doi.org/10.1093/chem... #microscopymonday
Multinucleated giant cells (MNGCs) emerge as ovaries age, and are hard to study. Here, Converse, Pritchard, Duncan et al. used 2p imaging with the Cousa objective pacificoptica.com/cousa/ in their comprehensive study of age-associated MNGCs. #microscopymonday www.biorxiv.org/content/10.1...
June 23, 2025 at 5:43 PM
Multinucleated giant cells (MNGCs) emerge as ovaries age, and are hard to study. Here, Converse, Pritchard, Duncan et al. used 2p imaging with the Cousa objective pacificoptica.com/cousa/ in their comprehensive study of age-associated MNGCs. #microscopymonday www.biorxiv.org/content/10.1...
There is a bunch more in the paper, including this variation for doubling the phase modulation off of an adaptive optic element. Limited range on your deformable mirror? Not a problem anymore. 8/9
June 16, 2025 at 5:57 PM
There is a bunch more in the paper, including this variation for doubling the phase modulation off of an adaptive optic element. Limited range on your deformable mirror? Not a problem anymore. 8/9
Here's imaging over 9 square mm of cortex in vivo. Resonant scanning at 16,000 lines / s. No stitching at all. 7/9
June 16, 2025 at 5:57 PM
Here's imaging over 9 square mm of cortex in vivo. Resonant scanning at 16,000 lines / s. No stitching at all. 7/9
The approach is diffraction-limited and provides excellent results. 6/9
June 16, 2025 at 5:57 PM
The approach is diffraction-limited and provides excellent results. 6/9
Here is his proof-of-concept for angle multiplication! 5/9
June 16, 2025 at 5:57 PM
Here is his proof-of-concept for angle multiplication! 5/9
Here is an animation of the basic idea, upon which Che-Hang Yu elaborated. 4/9
June 16, 2025 at 5:57 PM
Here is an animation of the basic idea, upon which Che-Hang Yu elaborated. 4/9
Solution: Che-Hang Yu et al. developed a suite of non-inertial devices to amplify the scan angle with no tradeoffs. 2x, 3x, 4x, and more. 3/9
June 16, 2025 at 5:57 PM
Solution: Che-Hang Yu et al. developed a suite of non-inertial devices to amplify the scan angle with no tradeoffs. 2x, 3x, 4x, and more. 3/9
Problem: If you want to scan a laser beam fast, ultimately inertia limits you. Faster = smaller mirror (lower numerical aperture / resolution) and/or smaller range of angles (field-of-view). We can describe this trade-off as a type of optical invariant. 2/9
June 16, 2025 at 5:57 PM
Problem: If you want to scan a laser beam fast, ultimately inertia limits you. Faster = smaller mirror (lower numerical aperture / resolution) and/or smaller range of angles (field-of-view). We can describe this trade-off as a type of optical invariant. 2/9
Riddle: When is an "optical invariant" is not so invariant? How can you get a larger field-of-view for free? No change in resolution or scan speed. No more stitching needed! For #MicroscopyMonday here's a new preprint to check out. 1/9
June 16, 2025 at 5:57 PM
Riddle: When is an "optical invariant" is not so invariant? How can you get a larger field-of-view for free? No change in resolution or scan speed. No more stitching needed! For #MicroscopyMonday here's a new preprint to check out. 1/9
Scientists at work.
This is a #ucsantabarbara collab with www.mbfbioscience.com Diesel2p pacificoptica.com/diesel2p/
This is a #ucsantabarbara collab with www.mbfbioscience.com Diesel2p pacificoptica.com/diesel2p/
May 29, 2025 at 6:25 AM
Scientists at work.
This is a #ucsantabarbara collab with www.mbfbioscience.com Diesel2p pacificoptica.com/diesel2p/
This is a #ucsantabarbara collab with www.mbfbioscience.com Diesel2p pacificoptica.com/diesel2p/
What’s new, etendue?
Spencer LaVere Smith will be presenting new optics at the @optica.org conference in San Diego tomorrow.
Spencer LaVere Smith will be presenting new optics at the @optica.org conference in San Diego tomorrow.
April 23, 2025 at 9:44 PM
What’s new, etendue?
Spencer LaVere Smith will be presenting new optics at the @optica.org conference in San Diego tomorrow.
Spencer LaVere Smith will be presenting new optics at the @optica.org conference in San Diego tomorrow.
Brand new online today. The biggest fields-of-view scanned fast, for multiphoton imaging. pacificoptica.com/ventana/
January 26, 2025 at 6:54 PM
Brand new online today. The biggest fields-of-view scanned fast, for multiphoton imaging. pacificoptica.com/ventana/
New products for two-photon imaging. Read and see dpecs here: pacificoptica.com/ventana/ Huge fields of view scanned fast. Unprecedented capabilities. #photonicswest
January 26, 2025 at 6:52 PM
New products for two-photon imaging. Read and see dpecs here: pacificoptica.com/ventana/ Huge fields of view scanned fast. Unprecedented capabilities. #photonicswest
If you need a last minute stocking stuffer, how about a set of Diesel2p optics? We can ship quickly! pacificoptica.com/diesel2p/
December 22, 2024 at 7:23 PM
If you need a last minute stocking stuffer, how about a set of Diesel2p optics? We can ship quickly! pacificoptica.com/diesel2p/
The Ventana SL and Ventana TL are now available. pacificoptica.com/ventana/ This is a new standard in scan engine optics. Nothing else comes close. These optics enable diffraction-limited imaging over a huge field-of-view. They're easy to integrate into your systems.
December 22, 2024 at 7:01 PM
The Ventana SL and Ventana TL are now available. pacificoptica.com/ventana/ This is a new standard in scan engine optics. Nothing else comes close. These optics enable diffraction-limited imaging over a huge field-of-view. They're easy to integrate into your systems.
We can help. We have new optics that unlock a large FOV, with diffraction limited resolution across the full field-of-view. (8/8) #FluorescenceFriday
December 20, 2024 at 8:17 PM
We can help. We have new optics that unlock a large FOV, with diffraction limited resolution across the full field-of-view. (8/8) #FluorescenceFriday