Winona Oliveros
@oliveroswinona.bsky.social
Microbiologist — Bioinformatics — PhD in Biomedicine/Bioinformatics (BSC) — Postdoc @ Lappalainen Lab
This work highlights the widespread and multi-layered impact of smoking on biological aging and reinforces the value of integrative, system-level approaches to public health research.
It’s been an immense pleasure to collaborate on this project with such a talented team!
It’s been an immense pleasure to collaborate on this project with such a talented team!
June 4, 2025 at 8:43 AM
This work highlights the widespread and multi-layered impact of smoking on biological aging and reinforces the value of integrative, system-level approaches to public health research.
It’s been an immense pleasure to collaborate on this project with such a talented team!
It’s been an immense pleasure to collaborate on this project with such a talented team!
In this study, we show how tobacco use accelerates aging across nearly all tissues in the human body; not just through histological changes, but also at the levels of DNA methylation and gene expression.
June 4, 2025 at 8:43 AM
In this study, we show how tobacco use accelerates aging across nearly all tissues in the human body; not just through histological changes, but also at the levels of DNA methylation and gene expression.
I’m so sorry to hear this, John. Keeping you and your family in my thoughts. When I faced something similar, what kept me going was thinking about how proud they are of what we do. Just spending time with them and doing your best really matters. You will get through this, I’m sure of it!
May 8, 2025 at 12:09 AM
I’m so sorry to hear this, John. Keeping you and your family in my thoughts. When I faced something similar, what kept me going was thinking about how proud they are of what we do. Just spending time with them and doing your best really matters. You will get through this, I’m sure of it!
Our work provides a detailed view of epigenetic variation under healthy conditions, a useful baseline for future epigenetic studies.
Big thanks to my amazing co-author @ramirezjmiguel.bsky.social, the best partner I could ever ask for! And to the best PhD mentor @martamele.bsky.social!
Big thanks to my amazing co-author @ramirezjmiguel.bsky.social, the best partner I could ever ask for! And to the best PhD mentor @martamele.bsky.social!
The impact of sex, age, and genetic ancestry on DNA methylation across tissues
Background: Understanding the consequences of individual DNA methylation variation is crucial for the study of human biology and disease. However, the collective impact of demographic traits on DNA me...
www.biorxiv.org
May 5, 2025 at 3:44 PM
Our work provides a detailed view of epigenetic variation under healthy conditions, a useful baseline for future epigenetic studies.
Big thanks to my amazing co-author @ramirezjmiguel.bsky.social, the best partner I could ever ask for! And to the best PhD mentor @martamele.bsky.social!
Big thanks to my amazing co-author @ramirezjmiguel.bsky.social, the best partner I could ever ask for! And to the best PhD mentor @martamele.bsky.social!
Aging & PRC:
Aging increases DNA methylation at PRC target sites across most tissues, consistent with the literature. But interestingly: not in the gonads!
Why gonads behave differently is still an open question.
Aging increases DNA methylation at PRC target sites across most tissues, consistent with the literature. But interestingly: not in the gonads!
Why gonads behave differently is still an open question.
May 5, 2025 at 3:44 PM
Aging & PRC:
Aging increases DNA methylation at PRC target sites across most tissues, consistent with the literature. But interestingly: not in the gonads!
Why gonads behave differently is still an open question.
Aging increases DNA methylation at PRC target sites across most tissues, consistent with the literature. But interestingly: not in the gonads!
Why gonads behave differently is still an open question.
Focusing on the sex differences, we found:
The female genome is hypermethylated across tissues.
Why? We hypothesize that it is likely due to the continuous activity of the Polycomb Repressive Complex (PRC), a key chromatin regulator in the X chromosome inactivation.
The female genome is hypermethylated across tissues.
Why? We hypothesize that it is likely due to the continuous activity of the Polycomb Repressive Complex (PRC), a key chromatin regulator in the X chromosome inactivation.
May 5, 2025 at 3:44 PM
Focusing on the sex differences, we found:
The female genome is hypermethylated across tissues.
Why? We hypothesize that it is likely due to the continuous activity of the Polycomb Repressive Complex (PRC), a key chromatin regulator in the X chromosome inactivation.
The female genome is hypermethylated across tissues.
Why? We hypothesize that it is likely due to the continuous activity of the Polycomb Repressive Complex (PRC), a key chromatin regulator in the X chromosome inactivation.
But does DNA methylation mediate gene expression changes?
Surprisingly, less than 10% of the expression variation linked to sex, age, or ancestry is explained by methylation, with ancestry showing the highest mediation.
Surprisingly, less than 10% of the expression variation linked to sex, age, or ancestry is explained by methylation, with ancestry showing the highest mediation.
May 5, 2025 at 3:44 PM
But does DNA methylation mediate gene expression changes?
Surprisingly, less than 10% of the expression variation linked to sex, age, or ancestry is explained by methylation, with ancestry showing the highest mediation.
Surprisingly, less than 10% of the expression variation linked to sex, age, or ancestry is explained by methylation, with ancestry showing the highest mediation.
Which factors matter most?
Genetic ancestry and age have stronger effects on methylation than sex.
But: (1) Age changes are widespread but modest. (2) Ancestry changes are more localized and often under genetic control.
Genetic ancestry and age have stronger effects on methylation than sex.
But: (1) Age changes are widespread but modest. (2) Ancestry changes are more localized and often under genetic control.
May 5, 2025 at 3:44 PM
Which factors matter most?
Genetic ancestry and age have stronger effects on methylation than sex.
But: (1) Age changes are widespread but modest. (2) Ancestry changes are more localized and often under genetic control.
Genetic ancestry and age have stronger effects on methylation than sex.
But: (1) Age changes are widespread but modest. (2) Ancestry changes are more localized and often under genetic control.
First: DNA methylation varies more than gene expression across individuals.
This suggests methylation captures broader inter-individual variability, possibly including environmental and genetic effects.
This suggests methylation captures broader inter-individual variability, possibly including environmental and genetic effects.
May 5, 2025 at 3:44 PM
First: DNA methylation varies more than gene expression across individuals.
This suggests methylation captures broader inter-individual variability, possibly including environmental and genetic effects.
This suggests methylation captures broader inter-individual variability, possibly including environmental and genetic effects.