Winona Oliveros
@oliveroswinona.bsky.social
Microbiologist — Bioinformatics — PhD in Biomedicine/Bioinformatics (BSC) — Postdoc @ Lappalainen Lab
Aging & PRC:
Aging increases DNA methylation at PRC target sites across most tissues, consistent with the literature. But interestingly: not in the gonads!
Why gonads behave differently is still an open question.
Aging increases DNA methylation at PRC target sites across most tissues, consistent with the literature. But interestingly: not in the gonads!
Why gonads behave differently is still an open question.
May 5, 2025 at 3:44 PM
Aging & PRC:
Aging increases DNA methylation at PRC target sites across most tissues, consistent with the literature. But interestingly: not in the gonads!
Why gonads behave differently is still an open question.
Aging increases DNA methylation at PRC target sites across most tissues, consistent with the literature. But interestingly: not in the gonads!
Why gonads behave differently is still an open question.
Focusing on the sex differences, we found:
The female genome is hypermethylated across tissues.
Why? We hypothesize that it is likely due to the continuous activity of the Polycomb Repressive Complex (PRC), a key chromatin regulator in the X chromosome inactivation.
The female genome is hypermethylated across tissues.
Why? We hypothesize that it is likely due to the continuous activity of the Polycomb Repressive Complex (PRC), a key chromatin regulator in the X chromosome inactivation.
May 5, 2025 at 3:44 PM
Focusing on the sex differences, we found:
The female genome is hypermethylated across tissues.
Why? We hypothesize that it is likely due to the continuous activity of the Polycomb Repressive Complex (PRC), a key chromatin regulator in the X chromosome inactivation.
The female genome is hypermethylated across tissues.
Why? We hypothesize that it is likely due to the continuous activity of the Polycomb Repressive Complex (PRC), a key chromatin regulator in the X chromosome inactivation.
But does DNA methylation mediate gene expression changes?
Surprisingly, less than 10% of the expression variation linked to sex, age, or ancestry is explained by methylation, with ancestry showing the highest mediation.
Surprisingly, less than 10% of the expression variation linked to sex, age, or ancestry is explained by methylation, with ancestry showing the highest mediation.
May 5, 2025 at 3:44 PM
But does DNA methylation mediate gene expression changes?
Surprisingly, less than 10% of the expression variation linked to sex, age, or ancestry is explained by methylation, with ancestry showing the highest mediation.
Surprisingly, less than 10% of the expression variation linked to sex, age, or ancestry is explained by methylation, with ancestry showing the highest mediation.
Which factors matter most?
Genetic ancestry and age have stronger effects on methylation than sex.
But: (1) Age changes are widespread but modest. (2) Ancestry changes are more localized and often under genetic control.
Genetic ancestry and age have stronger effects on methylation than sex.
But: (1) Age changes are widespread but modest. (2) Ancestry changes are more localized and often under genetic control.
May 5, 2025 at 3:44 PM
Which factors matter most?
Genetic ancestry and age have stronger effects on methylation than sex.
But: (1) Age changes are widespread but modest. (2) Ancestry changes are more localized and often under genetic control.
Genetic ancestry and age have stronger effects on methylation than sex.
But: (1) Age changes are widespread but modest. (2) Ancestry changes are more localized and often under genetic control.
First: DNA methylation varies more than gene expression across individuals.
This suggests methylation captures broader inter-individual variability, possibly including environmental and genetic effects.
This suggests methylation captures broader inter-individual variability, possibly including environmental and genetic effects.
May 5, 2025 at 3:44 PM
First: DNA methylation varies more than gene expression across individuals.
This suggests methylation captures broader inter-individual variability, possibly including environmental and genetic effects.
This suggests methylation captures broader inter-individual variability, possibly including environmental and genetic effects.
Yesterday I defended my PhD thesis at the UB after nearly 5 years of work at the BSC @melelab.bsky.social. I couldn’t be happier! This wouldn’t have been possible without my amazing friends and fellow PhD students. 💘🎉
April 8, 2025 at 10:27 AM
Yesterday I defended my PhD thesis at the UB after nearly 5 years of work at the BSC @melelab.bsky.social. I couldn’t be happier! This wouldn’t have been possible without my amazing friends and fellow PhD students. 💘🎉
Had a blast giving a talk at the CRG Medical Genomics Data Club last week! It was a privilege to share insights from my latest paper on how demographic traits shape DNA methylation patterns. Thank you all for the great engagement! 🎉 @crg.eu @melelab.bsky.social
December 16, 2024 at 3:31 PM
Had a blast giving a talk at the CRG Medical Genomics Data Club last week! It was a privilege to share insights from my latest paper on how demographic traits shape DNA methylation patterns. Thank you all for the great engagement! 🎉 @crg.eu @melelab.bsky.social