Inhibitory interneurons may help encode the brain’s internal representation of space

Abstract. Variation in over 100 genes are now associated with increased risk for autism and related neurodevelopmental conditions, but how this variation r

Some autistic individuals experience aversion to social touch. Authors use Neuropixels probes and demonstrate that unlike wild type mice, Fmr1 knockout mice find social and non-social interactions equ...

While cortical organoids have been used to model different facets of neurodevelopmental conditions and human brain evolution, cerebellar organoids have not yet featured so prominently in the same cont...

Synaptic plasticity underlies learning by modifying specific synaptic inputs to reshape neural activity and behavior. However, the rules governing which synapses will undergo different forms of plasti...

Studies reporting novel therapeutic effects of psychedelic drugs are rapidly emerging. However, the reproducibility and reliability of these findings could remain uncertain for years. Here, we impleme...

A pyramidal cell type and the 5-HT2A receptor in the medial frontal cortex have essential roles in psilocybin’s long-term drug action.

The development of the human neocortex is highly dynamic, involving complex cellular trajectories controlled by gene regulation1. Here we collected paired single-nucleus chromatin accessibility and transcriptome data from 38 human neocortical samples encompassing both the prefrontal cortex and the primary visual cortex. These samples span five main developmental stages, ranging from the first trimester to adolescence. In parallel, we performed spatial transcriptomic analysis on a subset of the samples to illustrate spatial organization and intercellular communication. This atlas enables us to catalogue cell-type-specific, age-specific and area-specific gene regulatory networks underlying neural differentiation. Moreover, combining single-cell profiling, progenitor purification and lineage-tracing experiments, we have untangled the complex lineage relationships among progenitor subtypes during the neurogenesis-to-gliogenesis transition. We identified a tripotential intermediate progenit

The search for neural mechanisms of behaviour often relies on a synchronic, driving view of causation, where neural activity drives more neural activity, which eventually drives behaviour. The real c...

Synaptic dysfunction underlies brain connectivity alterations in 22q11DS, a syndrome linked to neuropsychiatric disorders.

Behavioural experiments in mice demonstrate that GABAergic (γ-aminobutyric acid-expressing), glutamatergic and serotonergic neurons in the median raphe nucleus have distinct and complementary function...

The role of lateral inhibition for perception and neural computation remains unsolved. Del Rosario et al. show that distinct types of cortical interneurons in V1 drive lateral inhibition that causes s...

Behavioural-state-dependent pyramidal neurons have a distinct pattern of long-range glutamatergic inputs, with a larger proportion of thalamic versus motor cortex inputs compared with non-behavio...

Inhibitory interneurons play crucial roles in modulating the circuits and activity patterns of the cerebral cortex. In particular, interneurons must a…

Through circuit dissection in juvenile, adolescent and adult mice, Klune, Goodpaster and colleagues reveal multiple developmental switches in mPFC–NAc and mPFC–BLA pathways that underlie developmental...

Sensory experience transforms endogenously structured cortical networks with diverse and unreliable visual responses into reliable representations. This process is proposed to involve the alignment of feedforward and recurrent networks.

A challenge in psychiatric drug discovery is to predict the therapeutic potential of a novel compound. Here, the authors show that brain-wide imaging of immediate early gene expression can be used to ...

The brain efficiently processes sensory information by selecting novelty and discarding redundancies. In this work, Shymkiv et al. demonstrate that through a high-dimensional ensemble representation, ...

Fast instinctive responses to environmental stimuli can be crucial for survival but are not always optimal. Animals can adapt their behavior and suppress instinctive reactions, but the neural pathways...