Nicolas Robine 🇪🇺🇫🇷🇺🇸
@nicorobine.bsky.social
Computational Biologist. Mostly in English, sometimes in French. #NoPasaran
Looking more and more like his puppet on the French "Guignols de l'Info"
December 7, 2025 at 7:46 PM
Looking more and more like his puppet on the French "Guignols de l'Info"
Reposted by Nicolas Robine 🇪🇺🇫🇷🇺🇸
Out now in @natgenet.nature.com, our Comment analyzing uses of the Human Genome Diversity Project (HGDP), a controversial dataset in human genomics research. A 🧵
rdcu.be/eRu65
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rdcu.be/eRu65
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November 25, 2025 at 4:57 AM
Out now in @natgenet.nature.com, our Comment analyzing uses of the Human Genome Diversity Project (HGDP), a controversial dataset in human genomics research. A 🧵
rdcu.be/eRu65
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rdcu.be/eRu65
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"Concerns about the legitimacy and integrity of Nucleus Genomics", by X account @sichuan_mala
totalhealthoptimization.com/2025/11/21/c...
totalhealthoptimization.com/2025/11/21/c...
Concerns about the legitimacy and integrity of Nucleus Genomics – Total Health Optimization
totalhealthoptimization.com
November 25, 2025 at 1:35 AM
"Concerns about the legitimacy and integrity of Nucleus Genomics", by X account @sichuan_mala
totalhealthoptimization.com/2025/11/21/c...
totalhealthoptimization.com/2025/11/21/c...
Reposted by Nicolas Robine 🇪🇺🇫🇷🇺🇸
📢 SIGN & SHARE THE PETITION! 📢
New York needs an Empire Biomedical Research Institute to create new statewide funding opportunities for scientists & physician-scientists so that patients and their families get the life-saving and life-changing new therapeutics they're hoping for ✏️ c.org/TDMy2H9JTW
New York needs an Empire Biomedical Research Institute to create new statewide funding opportunities for scientists & physician-scientists so that patients and their families get the life-saving and life-changing new therapeutics they're hoping for ✏️ c.org/TDMy2H9JTW
Sign the Petition
Support a New York State Biomedical Institute for a Healthier, More Affordable Future
c.org
November 24, 2025 at 3:53 PM
📢 SIGN & SHARE THE PETITION! 📢
New York needs an Empire Biomedical Research Institute to create new statewide funding opportunities for scientists & physician-scientists so that patients and their families get the life-saving and life-changing new therapeutics they're hoping for ✏️ c.org/TDMy2H9JTW
New York needs an Empire Biomedical Research Institute to create new statewide funding opportunities for scientists & physician-scientists so that patients and their families get the life-saving and life-changing new therapeutics they're hoping for ✏️ c.org/TDMy2H9JTW
Who you gonna call? Which protein do you want to talk to? Can we talk to noncoding RNA too or will they be nonverbal?
November 20, 2025 at 8:05 PM
Who you gonna call? Which protein do you want to talk to? Can we talk to noncoding RNA too or will they be nonverbal?
Reposted by Nicolas Robine 🇪🇺🇫🇷🇺🇸
The NHGRI is finally ready to appoint a new director.
Deadline = 1 week from today.
hr.nih.gov/careers/open...
Deadline = 1 week from today.
hr.nih.gov/careers/open...
November 14, 2025 at 8:35 PM
The NHGRI is finally ready to appoint a new director.
Deadline = 1 week from today.
hr.nih.gov/careers/open...
Deadline = 1 week from today.
hr.nih.gov/careers/open...
November 13, 2025 at 6:35 PM
Reposted by Nicolas Robine 🇪🇺🇫🇷🇺🇸
A preprint‼️that's bound to ruffle some 🪶 "Widespread DNA off-targeting confounds studies of RNA chromatin occupancy" led by our Micah Goldrich and Louis Delhaye from
Pieter Mestdagh in Ghent. TL;DR we show that many of lncRNA chromatin occupancy obtained are flawed www.biorxiv.org/content/10.1...
Pieter Mestdagh in Ghent. TL;DR we show that many of lncRNA chromatin occupancy obtained are flawed www.biorxiv.org/content/10.1...
November 13, 2025 at 9:26 AM
A preprint‼️that's bound to ruffle some 🪶 "Widespread DNA off-targeting confounds studies of RNA chromatin occupancy" led by our Micah Goldrich and Louis Delhaye from
Pieter Mestdagh in Ghent. TL;DR we show that many of lncRNA chromatin occupancy obtained are flawed www.biorxiv.org/content/10.1...
Pieter Mestdagh in Ghent. TL;DR we show that many of lncRNA chromatin occupancy obtained are flawed www.biorxiv.org/content/10.1...
Look what just arrived @greally.bsky.social
November 11, 2025 at 6:24 PM
Look what just arrived @greally.bsky.social
James Watson, Co-Discoverer of the Structure of DNA, Is Dead at 97
www.nytimes.com/2025/11/07/s...
Complicated legacy obviously, but a towering figure for our field.
www.nytimes.com/2025/11/07/s...
Complicated legacy obviously, but a towering figure for our field.
James Watson, Who Helped Discover the Structure of DNA, Is Dead at 97
www.nytimes.com
November 7, 2025 at 7:32 PM
James Watson, Co-Discoverer of the Structure of DNA, Is Dead at 97
www.nytimes.com/2025/11/07/s...
Complicated legacy obviously, but a towering figure for our field.
www.nytimes.com/2025/11/07/s...
Complicated legacy obviously, but a towering figure for our field.
October 26, 2025 at 9:46 AM
Reposted by Nicolas Robine 🇪🇺🇫🇷🇺🇸
Hi everyone! I'm working with Visium spatial transcriptomics data deconvolved with cell2location. Need advice on calculating gene signature scores (e.g., acidosis) from deconvolved expression layers. 🧬🖥️ #spatialtranscriptomics
October 22, 2025 at 1:00 PM
Hi everyone! I'm working with Visium spatial transcriptomics data deconvolved with cell2location. Need advice on calculating gene signature scores (e.g., acidosis) from deconvolved expression layers. 🧬🖥️ #spatialtranscriptomics
Reposted by Nicolas Robine 🇪🇺🇫🇷🇺🇸
Vous êtes étudiant(e) en informatique, ingénierie ou mathématiques dans une université ou une grande école ? La biologie et le fonctionnement du vivant vous intéressent ? Envie d'élargir vos horizons ?
Ce stage pourrait vous convenir.
www.ebi.ac.uk/about/jobs/i...
Ce stage pourrait vous convenir.
www.ebi.ac.uk/about/jobs/i...
EMBL-EBI / Embassy of France in London Internships
In collaboration with the Embassy of France in London, we are offering a number of paid internships to computer-science, statistics and bioinformatics students.
www.ebi.ac.uk
October 23, 2025 at 7:33 AM
Vous êtes étudiant(e) en informatique, ingénierie ou mathématiques dans une université ou une grande école ? La biologie et le fonctionnement du vivant vous intéressent ? Envie d'élargir vos horizons ?
Ce stage pourrait vous convenir.
www.ebi.ac.uk/about/jobs/i...
Ce stage pourrait vous convenir.
www.ebi.ac.uk/about/jobs/i...
Reposted by Nicolas Robine 🇪🇺🇫🇷🇺🇸
trying to find a preprint, stumbled across this concurrent work published just a few weeks ago from an unrelated lab which is also based in new york. weird. www.cell.com/current-biol...
Transcriptional interference gates monogenic odorant receptor expression in ants
Ant pheromone communication relies on an expanded odorant receptor repertoire, with
many genes in large genomic tandem arrays. Glotzer et al. describe a novel mechanism,
conserved across ants and othe...
www.cell.com
October 22, 2025 at 9:22 PM
trying to find a preprint, stumbled across this concurrent work published just a few weeks ago from an unrelated lab which is also based in new york. weird. www.cell.com/current-biol...
Transcriptional interferences ensure one olfactory receptor per ant neuron
www.nature.com/articles/s41...
Caviar for RNA-Seq nerds! Check this out
www.nature.com/articles/s41...
Caviar for RNA-Seq nerds! Check this out
October 22, 2025 at 8:40 PM
Transcriptional interferences ensure one olfactory receptor per ant neuron
www.nature.com/articles/s41...
Caviar for RNA-Seq nerds! Check this out
www.nature.com/articles/s41...
Caviar for RNA-Seq nerds! Check this out
Reposted by Nicolas Robine 🇪🇺🇫🇷🇺🇸
We investigated Constellation from Illumina @bcmhgsc.bsky.social for rare disease cases @gregor-research.bsky.social from @bcmhouston.bsky.social.
We tested HG002-4 & sequenced 21 families. We could detangle complex SV & other interesting findings described here: www.medrxiv.org/content/10.1...
We tested HG002-4 & sequenced 21 families. We could detangle complex SV & other interesting findings described here: www.medrxiv.org/content/10.1...
Constellation illuminates rare disease genetics
Despite significant advances in genomic sequencing, the resolution of many rare disease cases is still hindered by variant detection limitations. Short reads struggle in homologous regions, and long r...
www.medrxiv.org
October 20, 2025 at 1:40 PM
We investigated Constellation from Illumina @bcmhgsc.bsky.social for rare disease cases @gregor-research.bsky.social from @bcmhouston.bsky.social.
We tested HG002-4 & sequenced 21 families. We could detangle complex SV & other interesting findings described here: www.medrxiv.org/content/10.1...
We tested HG002-4 & sequenced 21 families. We could detangle complex SV & other interesting findings described here: www.medrxiv.org/content/10.1...
Finally saw a job offer that's compliant with New York state laws, but in a pretty useless way:
Pay Range: $0.00 - $10,000,000.00
Pay Range: $0.00 - $10,000,000.00
October 17, 2025 at 3:50 PM
Finally saw a job offer that's compliant with New York state laws, but in a pretty useless way:
Pay Range: $0.00 - $10,000,000.00
Pay Range: $0.00 - $10,000,000.00
Reposted by Nicolas Robine 🇪🇺🇫🇷🇺🇸
Accurate somatic small variant discovery for multiple sequencing technologies with DeepSomatic www.nature.com/articles/s41... (read free: rdcu.be/eLny0) github.com/google/deeps...
October 16, 2025 at 7:29 PM
Accurate somatic small variant discovery for multiple sequencing technologies with DeepSomatic www.nature.com/articles/s41... (read free: rdcu.be/eLny0) github.com/google/deeps...
Reposted by Nicolas Robine 🇪🇺🇫🇷🇺🇸
Big, beautiful trees!!
SMART-PTA for whole-genome+transcriptome on thousand of single cells from the normal human esophagus 🤯 Massively scaling up the power of scWGS to build deep phylogenies and chart somatic evolution from birth throughout life.
www.biorxiv.org/content/10.1...
SMART-PTA for whole-genome+transcriptome on thousand of single cells from the normal human esophagus 🤯 Massively scaling up the power of scWGS to build deep phylogenies and chart somatic evolution from birth throughout life.
www.biorxiv.org/content/10.1...
October 14, 2025 at 2:37 PM
Big, beautiful trees!!
SMART-PTA for whole-genome+transcriptome on thousand of single cells from the normal human esophagus 🤯 Massively scaling up the power of scWGS to build deep phylogenies and chart somatic evolution from birth throughout life.
www.biorxiv.org/content/10.1...
SMART-PTA for whole-genome+transcriptome on thousand of single cells from the normal human esophagus 🤯 Massively scaling up the power of scWGS to build deep phylogenies and chart somatic evolution from birth throughout life.
www.biorxiv.org/content/10.1...
Reposted by Nicolas Robine 🇪🇺🇫🇷🇺🇸
9 days to go:
* 2 x open positions!
* Exceptional environment, competitive start-up package
* University of Toronto appointments
* Toronto has great (and peaceful) quality of life!
* 2 x open positions!
* Exceptional environment, competitive start-up package
* University of Toronto appointments
* Toronto has great (and peaceful) quality of life!
JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto.
www.nature.com/naturecareer...
Please repost!
www.nature.com/naturecareer...
Please repost!
October 11, 2025 at 12:40 PM
9 days to go:
* 2 x open positions!
* Exceptional environment, competitive start-up package
* University of Toronto appointments
* Toronto has great (and peaceful) quality of life!
* 2 x open positions!
* Exceptional environment, competitive start-up package
* University of Toronto appointments
* Toronto has great (and peaceful) quality of life!
Still awesome. And here is my new favorite sequencing machine:
October 11, 2025 at 2:02 AM
Still awesome. And here is my new favorite sequencing machine:
I found a doctor to get a second opinion for my dad 6000km away and it let to a dramatic improvement in the health condition that was plaguing his (and my mother's) life.
Hard to tell if it would have happened without Twitter.
Hard to tell if it would have happened without Twitter.
Has anything great happened in your life because of social media?
October 8, 2025 at 5:53 PM
I found a doctor to get a second opinion for my dad 6000km away and it let to a dramatic improvement in the health condition that was plaguing his (and my mother's) life.
Hard to tell if it would have happened without Twitter.
Hard to tell if it would have happened without Twitter.