Nicolò Caporale
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nicolocaporale.bsky.social
Nicolò Caporale
@nicolocaporale.bsky.social
Medical Doctor. Researcher. Between environment & genomes for human health & development. #Organoids #SingleCellsOmics #EndocrineDisruptors
Towards a mathematical approach to neurobiology
Reposted by Nicolò Caporale
🤩 The February issue of @naturemethods.bsky.social features on its cover the research of our Giuseppe Testa Group on mosaic organoids to study the brains of multiple patients simultaneously.

Read more about the research 👉 humantechnopole.it/en/news/mosa...
Our February issue is live! 🎉
nature.com/nmeth/volume...

On the cover, a human brain emerges from multiple stem cell lineages, representing a method to link genetic variation to neurodevelopmental trajectories.

Paper here: nature.com/articles/s41...

Image by Philipp Dexheimer.
February 12, 2025 at 3:39 PM
Reposted by Nicolò Caporale
Multiplexing cortical brain organoids for the longitudinal dissection of developmental traits at single-cell resolution

www.nature.com/articles/s41...

@naturemethods.bsky.social

A new computational method SCanSNP & consensus call to deconvolve cell identities
Multiplexing cortical brain organoids for the longitudinal dissection of developmental traits at single-cell resolution - Nature Methods
This paper develops two approaches for multiplexing cortical organoids and SCanSNP, a method for deconvolving cell identities, to trace neurodevelopmental trajectories at scale.
www.nature.com
December 9, 2024 at 10:43 PM
Reposted by Nicolò Caporale
Today we report in 𝘾𝙚𝙡𝙡 𝙎𝙩𝙚𝙢 𝘾𝙚𝙡𝙡 a systematic approach to generate neural #organoids resembling various domains of the neural axis
Neal Amin & @kevinkelley.bsky.social developed a multiplexed morphogen screen to generate #organoids that mapped to almost 2/3 of the clusters in the 1st trimester CNS
December 5, 2024 at 10:13 PM
Reposted by Nicolò Caporale
Great to see our paper online!

Amazing collaboration with Neal over the years, with lots of help from others in the Pasca group.
Today we report in 𝘾𝙚𝙡𝙡 𝙎𝙩𝙚𝙢 𝘾𝙚𝙡𝙡 a systematic approach to generate neural #organoids resembling various domains of the neural axis
Neal Amin & @kevinkelley.bsky.social developed a multiplexed morphogen screen to generate #organoids that mapped to almost 2/3 of the clusters in the 1st trimester CNS
December 6, 2024 at 9:28 PM