Nicolas Bery
@nicolasbery.bsky.social
Research scientist at Cancer Research Centre of Toulouse/Inserm | Pancreatic cancer, intracellular antibody, biodegrader, PPI | Views are my own
Reposted by Nicolas Bery
I am organizing a Special Issue in Cancers with Eric Chastre & Larissa Kotelevets on PTEN Regulation. 7 papers published so far and deadline is fixed for 31 Dec 2025. Please reach out if you are interested in contributing.
July 19, 2025 at 6:34 AM
I am organizing a Special Issue in Cancers with Eric Chastre & Larissa Kotelevets on PTEN Regulation. 7 papers published so far and deadline is fixed for 31 Dec 2025. Please reach out if you are interested in contributing.
Reposted by Nicolas Bery
Delighted to share our new preprint revealing a novel mechanism of ATR inhibitor sensitivity linked to lethal origin firing, thanks Sarah @mcclellandlab.bsky.social and collaborators!
Happy to post our first preprint in a while! www.biorxiv.org/content/10.1.... This was a slightly new direction for us, spearheaded by amazing post-doc @audreylumeau.bsky.social. Short thread to follow 🧬
March 7, 2025 at 9:30 PM
Delighted to share our new preprint revealing a novel mechanism of ATR inhibitor sensitivity linked to lethal origin firing, thanks Sarah @mcclellandlab.bsky.social and collaborators!
Reposted by Nicolas Bery
VIPER-TACs leverage viral E3 ligases for disease-specific targeted protein degradation
www.cell.com/cell-chemica...
www.cell.com/cell-chemica...
March 6, 2025 at 1:12 AM
VIPER-TACs leverage viral E3 ligases for disease-specific targeted protein degradation
www.cell.com/cell-chemica...
www.cell.com/cell-chemica...
Reposted by Nicolas Bery
3 points of progress vs pancreatic cancer!
1. Neoantigen vaccines
www.nature.com/articles/s41...
2. KRAS drugs
www.wsj.com/health/healt...
3. Early diagnosis www.science.org/doi/10.1126/...
1. Neoantigen vaccines
www.nature.com/articles/s41...
2. KRAS drugs
www.wsj.com/health/healt...
3. Early diagnosis www.science.org/doi/10.1126/...
March 1, 2025 at 3:26 PM
3 points of progress vs pancreatic cancer!
1. Neoantigen vaccines
www.nature.com/articles/s41...
2. KRAS drugs
www.wsj.com/health/healt...
3. Early diagnosis www.science.org/doi/10.1126/...
1. Neoantigen vaccines
www.nature.com/articles/s41...
2. KRAS drugs
www.wsj.com/health/healt...
3. Early diagnosis www.science.org/doi/10.1126/...
Reposted by Nicolas Bery
A different kind of Pac-Man! An innovative, rapid nanosensor assay to help diagnose early pancreatic cancer in people at high-risk (PAC-MANN)
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Early detection of pancreatic cancer by a high-throughput protease-activated nanosensor assay
A high-throughput, noninvasive, rapid protease-activated nanosensor identifies patients with pancreatic cancer in a small volume of blood.
www.science.org
February 12, 2025 at 7:58 PM
A different kind of Pac-Man! An innovative, rapid nanosensor assay to help diagnose early pancreatic cancer in people at high-risk (PAC-MANN)
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Congrats @lmkdassama.bsky.social and all co-authors for this comprehensive review on biodegraders! A must read.
Excited to share this beast of a review on the potential of protein-based degraders from trainees who are all not on the Sky! Herein we cover choice of binders, selection strategies, E3 ligases, and DELIVERY! pubs.acs.org/doi/10.1021/...
Protein-Based Degraders: From Chemical Biology Tools to Neo-Therapeutics
The nascent field of targeted protein degradation (TPD) could revolutionize biomedicine due to the ability of degrader molecules to selectively modulate disease-relevant proteins. A key limitation to ...
pubs.acs.org
January 18, 2025 at 11:29 AM
Congrats @lmkdassama.bsky.social and all co-authors for this comprehensive review on biodegraders! A must read.
Reposted by Nicolas Bery
Happy to share our latest review on SOCS proteins and their role and therapeutic potential as targets in immunology. To date, drug discovery targeting SOCS proteins have been elusive, due to the difficulty to drug their polar SH2 domain.. 1/3
www.frontiersin.org/journals/imm...
www.frontiersin.org/journals/imm...
Frontiers | Unravelling the druggability and immunological roles of the SOCS-family proteins
www.frontiersin.org
December 8, 2024 at 1:02 PM
Happy to share our latest review on SOCS proteins and their role and therapeutic potential as targets in immunology. To date, drug discovery targeting SOCS proteins have been elusive, due to the difficulty to drug their polar SH2 domain.. 1/3
www.frontiersin.org/journals/imm...
www.frontiersin.org/journals/imm...
It was a great pleasure to present @CellSymposia #CSchembio2024 our work on intracellular biodegraders in beautiful San Francisco!! Thanks to the organisers for this opportunity! @mariesorbara.bsky.social
December 4, 2024 at 6:04 AM
It was a great pleasure to present @CellSymposia #CSchembio2024 our work on intracellular biodegraders in beautiful San Francisco!! Thanks to the organisers for this opportunity! @mariesorbara.bsky.social