@ngoccao.bsky.social
Pinned
Thrilled to share our latest @cp-cell.bsky.social.
We present VICAR (VIral-induced Centromeric DNA Amplification and Recognition), a new defense system to detect viruses in the nucleus based on nuclear cGAS.
www.cell.com/cell/abstrac...
We present VICAR (VIral-induced Centromeric DNA Amplification and Recognition), a new defense system to detect viruses in the nucleus based on nuclear cGAS.
www.cell.com/cell/abstrac...
Centromeric DNA amplification triggered by viral proteins activates nuclear cGAS
Herpesvirus proteins disrupt centromeres, triggering centromeric DNA amplification
and local nuclear activation of the nucleic acid sensor cGAS. This reveals an immune
surveillance mechanism in the nu...
www.cell.com
Congratulations to everyone ! 🥳 Thank you so much Dr. Manel for your supervision during my master thesis! I am so happy to be part of this collaborative effort!
Reposted
Here is the schedule for the next TriRhena Gene Regulation Club at the FMI @fmiscience.bsky.social in Basel 🇨🇭 next week (5 Nov 2025; 14:00-18:45).
Exciting topics ahead & we are looking forward to the #newPI talks by @julianeg.bsky.social (MPI) & Anupama Hemalatha (FMI).
www.ie-freiburg.mpg.de/grc
Exciting topics ahead & we are looking forward to the #newPI talks by @julianeg.bsky.social (MPI) & Anupama Hemalatha (FMI).
www.ie-freiburg.mpg.de/grc
October 30, 2025 at 9:17 AM
Here is the schedule for the next TriRhena Gene Regulation Club at the FMI @fmiscience.bsky.social in Basel 🇨🇭 next week (5 Nov 2025; 14:00-18:45).
Exciting topics ahead & we are looking forward to the #newPI talks by @julianeg.bsky.social (MPI) & Anupama Hemalatha (FMI).
www.ie-freiburg.mpg.de/grc
Exciting topics ahead & we are looking forward to the #newPI talks by @julianeg.bsky.social (MPI) & Anupama Hemalatha (FMI).
www.ie-freiburg.mpg.de/grc
Reposted
Happy to share our latest publication, in which we show that the arrangement of nucleosomes around CTCF sites contributes to higher-order organisation of chromatin into TADs: www.embopress.org/doi/full/10....
October 27, 2025 at 11:49 AM
Happy to share our latest publication, in which we show that the arrangement of nucleosomes around CTCF sites contributes to higher-order organisation of chromatin into TADs: www.embopress.org/doi/full/10....
Reposted
Our paper is now out in Molecular Cell!
Check the thread in this former post:
www.cell.com/molecular-ce...
Check the thread in this former post:
www.cell.com/molecular-ce...
July 17, 2025 at 5:41 PM
Our paper is now out in Molecular Cell!
Check the thread in this former post:
www.cell.com/molecular-ce...
Check the thread in this former post:
www.cell.com/molecular-ce...
I am excited and honoured to share that I was selected as a recipient of the 𝐁𝐞𝐬𝐭 𝐏𝐨𝐬𝐭𝐞𝐫 𝐀𝐰𝐚𝐫𝐝 at the 𝟐𝟎𝟐𝟓 𝐆𝐨𝐫𝐝𝐨𝐧 𝐑𝐞𝐬𝐞𝐚𝐫𝐜𝐡 𝐂𝐨𝐧𝐟𝐞𝐫𝐞𝐧𝐜𝐞 𝐨𝐧 𝐆𝐞𝐧𝐨𝐦𝐞 𝐀𝐫𝐜𝐡𝐢𝐭𝐞𝐜𝐭𝐮𝐫𝐞 𝐢𝐧 𝐂𝐞𝐥𝐥 𝐅𝐚𝐭𝐞 𝐚𝐧𝐝 𝐃𝐢𝐬𝐞𝐚𝐬𝐞 🎉.
(see 🧵 below)
(see 🧵 below)
June 25, 2025 at 3:26 PM
I am excited and honoured to share that I was selected as a recipient of the 𝐁𝐞𝐬𝐭 𝐏𝐨𝐬𝐭𝐞𝐫 𝐀𝐰𝐚𝐫𝐝 at the 𝟐𝟎𝟐𝟓 𝐆𝐨𝐫𝐝𝐨𝐧 𝐑𝐞𝐬𝐞𝐚𝐫𝐜𝐡 𝐂𝐨𝐧𝐟𝐞𝐫𝐞𝐧𝐜𝐞 𝐨𝐧 𝐆𝐞𝐧𝐨𝐦𝐞 𝐀𝐫𝐜𝐡𝐢𝐭𝐞𝐜𝐭𝐮𝐫𝐞 𝐢𝐧 𝐂𝐞𝐥𝐥 𝐅𝐚𝐭𝐞 𝐚𝐧𝐝 𝐃𝐢𝐬𝐞𝐚𝐬𝐞 🎉.
(see 🧵 below)
(see 🧵 below)
Reposted
Check our latest with Yacine Kherdjemil and @eileen-furlong.bsky.social and our colleagues, where we show Chip (Ldb1) is essential only at a narrow window of embryogenesis overlapping ZGA. It functionally and physically bridges CBP to Zelda to regulate gene expression. www.cell.com/molecular-ce...
Chip (Ldb1) is a putative cofactor of Zelda forming a functional bridge to CBP during zygotic genome activation
Chip/Ldb1 is a crucial cofactor regulating enhancer function and chromatin interactions.
Using optogenetics, Galouzis, Kherdjemil et al. show that Chip is only essential during
zygotic genome activati...
www.cell.com
June 10, 2025 at 7:49 AM
Check our latest with Yacine Kherdjemil and @eileen-furlong.bsky.social and our colleagues, where we show Chip (Ldb1) is essential only at a narrow window of embryogenesis overlapping ZGA. It functionally and physically bridges CBP to Zelda to regulate gene expression. www.cell.com/molecular-ce...
Congratulations to everyone ! 🥳 Thank you so much Dr. Manel for your supervision during my master thesis! I am so happy to be part of this collaborative effort!
Thrilled to share our latest @cp-cell.bsky.social.
We present VICAR (VIral-induced Centromeric DNA Amplification and Recognition), a new defense system to detect viruses in the nucleus based on nuclear cGAS.
www.cell.com/cell/abstrac...
We present VICAR (VIral-induced Centromeric DNA Amplification and Recognition), a new defense system to detect viruses in the nucleus based on nuclear cGAS.
www.cell.com/cell/abstrac...
Centromeric DNA amplification triggered by viral proteins activates nuclear cGAS
Herpesvirus proteins disrupt centromeres, triggering centromeric DNA amplification
and local nuclear activation of the nucleic acid sensor cGAS. This reveals an immune
surveillance mechanism in the nu...
www.cell.com
June 2, 2025 at 4:12 PM
Congratulations to everyone ! 🥳 Thank you so much Dr. Manel for your supervision during my master thesis! I am so happy to be part of this collaborative effort!
Reposted
Congratulations to first authors Magdalena Karpinska and Yi Zhu and many thanks to all co-authors and the very helpful editors and reviewers! Special thanks to @dariloops.bsky.social for a great summary: www.nature.com/articles/s41...
Decoupling chromatin hubs from gene control - Nature Structural & Molecular Biology
Chromatin hubs, which are formed during cell differentiation, are characterized by simultaneous interactions between multiple regulatory elements and gene promoters. Research now shows that the disrup...
www.nature.com
May 13, 2025 at 9:43 AM
Congratulations to first authors Magdalena Karpinska and Yi Zhu and many thanks to all co-authors and the very helpful editors and reviewers! Special thanks to @dariloops.bsky.social for a great summary: www.nature.com/articles/s41...
Congratulations to all! Thank you so much for including me in this work!
Very happy to share the peer-reviewed version of our paper in which we study the formation and function of pair-wise and multi-way enhancer-promoter interactions in gene regulation (see thread below): www.nature.com/articles/s41...
May 13, 2025 at 11:09 AM
Congratulations to all! Thank you so much for including me in this work!
Reposted
Many congratulations to *Dr.* Shyam Ramasamy for a fantastic PhD thesis & defence! A very well deserved summa cum laude 🥳
March 28, 2025 at 12:10 PM
Many congratulations to *Dr.* Shyam Ramasamy for a fantastic PhD thesis & defence! A very well deserved summa cum laude 🥳
Reposted
Our latest work: how can compartmentalization emerge in a eukaryotic genome lacking canonical heterochromatin?
By investigating bacterial genomes put in yeast, we show that the presence or absence of transcription is sufficient!
#chromatin #3Dgenome #generegulation
www.science.org/doi/10.1126/...
👇
By investigating bacterial genomes put in yeast, we show that the presence or absence of transcription is sufficient!
#chromatin #3Dgenome #generegulation
www.science.org/doi/10.1126/...
👇
Sequence-dependent activity and compartmentalization of foreign DNA in a eukaryotic nucleus
In eukaryotes, DNA-associated protein complexes coevolve with genomic sequences to orchestrate chromatin folding. We investigate the relationship between DNA sequence and the spontaneous loading and a...
www.science.org
February 7, 2025 at 10:22 AM
Our latest work: how can compartmentalization emerge in a eukaryotic genome lacking canonical heterochromatin?
By investigating bacterial genomes put in yeast, we show that the presence or absence of transcription is sufficient!
#chromatin #3Dgenome #generegulation
www.science.org/doi/10.1126/...
👇
By investigating bacterial genomes put in yeast, we show that the presence or absence of transcription is sufficient!
#chromatin #3Dgenome #generegulation
www.science.org/doi/10.1126/...
👇