Invited speaker José María Frade @jmfrade.bsky.social (@institutocajal.bsky.social #Tetraneuron) shared insights during the opening lecture.
The event also welcomed over a dozen companies from biotech, pharma, and healthcare, fostering collaboration and innovation.
With the support of IVACE+i

Results are preclinical, yet promising towards new sex-adapted treatments for alcohol use disorder.
Read the full paper here 👇
doi.org/10.1016/j.bi...
@csic.es @umh.es @dicv.csic.es @ageinves.bsky.social @cienciagob.bsky.social @sommalliance.bsky.social @isciiisalud.bsky.social

The team also tested MCH11 in combination with topiramate (a drug already used clinically), obtaining the most effective response.
📌 Key findings:
• MCH11 restores altered gene expression linked to alcohol use disorder
• Shows potential as a future personalized therapy

In mice, MCH11 reduced alcohol intake and anxiety during withdrawal without impairing motor or cognitive function.
Results also reveal sex-dependent differences: males respond to low/medium doses, while females require higher doses for comparable effects.

Researchers at NeuroAlc have shown that MCH11 targets the endocannabinoid system, increasing 2-AG levels in the brain and restoring circuits involved in motivation, stress, and reward, reducing alcohol intake and withdrawal-related anxiety in mice.
🖼️Biomedicine & Pharmacotherapy

Sigue en directo #100xCiencia9 🙌
🔹 Streaming 13/11: youtube.com/live/RN-Shel...
🔹 Streaming 14/11: youtube.com/live/SzMAUYJ...
Organizan: @sommalliance.bsky.social, @iatacsic.bsky.social, @icmoluv.bsky.social,
@itq-upvcsic.bsky.social, #IFIC y @neuroalc.bsky.social

#CienciaParaLaSociedad

In parallel, @kardamakis.bsky.social & Giovanni Usseglio authored a chapter in the Evolution of Nervous Systems (Elsevier), showing that visuomotor circuits in fish, amphibians, reptiles, birds, and mammals share the same ancestral architecture for attention and gaze👇
doi.org/10.1016/B978...

This study is the result of an international collaboration between the @neuroalc.bsky.social, @ki.se, @kthuniversity.bsky.social, and the Massachusetts Institute of Technology.
You can read the full paper here 👇
doi.org/10.1371/jour...
@csic.es @umh.es @dicv.csic.es @ageinves.bsky.social

The superior colliculus acts as a biological radar: it receives direct retinal input and, before information reaches cortex, selects the most relevant stimuli. When something moves, flashes or appears, it is the first to respond and orient our gaze.
📷Peng Cui @plosbiology.org

Using patterned optogenetics, electrophysiology and computational modelling, the team shows that the superior colliculus generates center–surround interactions, a key computation that enhances contrast and visual saliency.
➡️ In short: this ancient structure selects what matters.