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NephMadness
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#NephMadness 2025 is live on the #AJKDBlog: https://bit.ly/WelcomeNM25 | Organized by @ajkd.bsky.social
If you submitted a #NephMadness bracket, check your score here:
bit.ly/2GZNoEl

0 perfect brackets...

Congrats to these folks (including @melhoenig.bsky.social and @glombandit.bsky.social) tied in first place with 25 points!

Stay tuned for the winners announcement later this week...
April 8, 2025 at 9:26 PM
Here is the final #NephMadness 2025 bracket with CAR-T for Autoimmune Diseases crowned as champion!

To Commiserate or Celebrate: #NephMadness
April 8, 2025 at 9:26 PM
How did the crowd vote?

22% for 🏆Team CAR-T for Autoimmune Diagnosis🏆 tied with 22% for Novel Drugs for Hypertension

#NephMadness

bit.ly/NM25Champ
April 8, 2025 at 9:26 PM
🏆CAR-T for Autoimmune Diagnosis🏆 wins 5-4 vs MCD Diagnosis and Pathogenesis

BRP Comment:
“Usually by the time we get to the final match up, the winner is obvious...but this final match up was one of the toughest choices of all time.”

#NephMadness

bit.ly/NM25Champ
April 8, 2025 at 9:26 PM
Filtered Four results will be revealed tomorrow!

Until then, check out the current #NephMadness 2025 Bracket and read the Blue Ribbon Panel comments defending their picks: bit.ly/NM25Effluent8
April 3, 2025 at 4:19 PM
Did the Blue Ribbon Panel keep you alive or break your heart and your bracket after just the first round?

Check how your #NephMadness bracket is doing: bit.ly/2GZNoEl

33 brackets tie for the top of the leaderboard!
April 2, 2025 at 8:52 PM
In the Minimal Change Disease Region:

🏆MCD Diagnosis and Pathogenesis wins 5-4 against MCD Relapse

BRP Comment: “Anti-nephrin FTW! New biomarker > better diagnosis, potentially better/more targeted therapy…”

bit.ly/NM25MCD
April 2, 2025 at 8:52 PM
Obesity in Kidney Transplant Region:

🏆Obesity in Donors wins 6-3 against Obesity in Recipients

BRP Comment:
"My vote is for obesity in donors here, especially re: weight loss clinics…though who will staff these clinics is a huge question"

bit.ly/NM25Obesity
April 2, 2025 at 8:52 PM
Green House: 🏆Tubular Toxins Wins 7-2 vs Oxalate Offenders

BRP Comment: “...I’d still vote for Tubular Toxins because the risk extends beyond diet and affects a larger group of kidney patients, including those with CKD, transplants, and dialysis."

bit.ly/NM25GreenHouse
April 2, 2025 at 8:52 PM
In the Hemodialysis Region:

🏆Incremental Dialysis wins 5-4 against Hemodiafiltration

BRP Comment:
“Since we don’t really know how fast to go, let’s make it incremental!”

bit.ly/NM25Hemodialysis
April 2, 2025 at 8:52 PM
CAR-T for Kidney Disease:

🏆CAR-T for Autoimmune Disease wins 5-4 against CAR-T Side Effects

BRP Comment:
“Although side effects are clearly a major hurdle, they’re just that: a hurdle to be jumped, not an impassable roadblock. Therapy wins.”

bit.ly/NM25CART
April 2, 2025 at 8:52 PM
In the Genetics Region:

🏆Genetics in FSGS wins 6-3 against Genetic Counseling

BRP Comment:
“This is easy, you cannot counsel anyone until you make the diagnosis....Genetics in FSGS for the win.”

bit.ly/NM25Genetics
April 2, 2025 at 8:52 PM
In the Disaster Nephrology Region:

🏆Kidney Care In Natural Disasters wins 7-2 against Team Kidney Care In Conflict

BRP Comment:
“It’s almost unnatural how often natural disasters are happening!”

bit.ly/NM25DisasterNeph
April 2, 2025 at 8:52 PM
In the Resistant Hypertension Region:

🏆Novel Drugs for Hypertension wins 8-1 against Renal Denervation

BRP Comment:
"With so many tried and true meds (and emerging options!), why risk the unknowns of denervation?”

bit.ly/NM25NovelRx4HTN
April 2, 2025 at 8:52 PM
Obesity is common in kidney transplant recipients. This confers both short and long term risks. Lifestyle interventions, pharmacotherapies, and bariatric surgery should be considered.

bit.ly/NM25ObesityinRecipients

#NephMadness
March 31, 2025 at 2:42 PM
The aging population and rise in obesity have affected the living donor population, and it remains challenging to balance obese donors’ safety and reasonable risk with their desire to donate:

bit.ly/NM25ObesityinDonors

#NephMadness
March 31, 2025 at 2:42 PM
Should all hemodialysis patients be treated the same? The dose of hemodialysis is based on largely anuric individuals, but what if your patient still has significant residual kidney function?

bit.ly/NM25IncrementalDialysis

#NephMadness
March 31, 2025 at 2:34 PM
Despite being around since the 1970s, hemodiafiltration, which adds convective clearance to diffusive clearance, has recently been thrust back into the spotlight as possibly being beneficial when compared to traditional hemodialysis.

bit.ly/NM25HDHemodiafiltration

#NephMadness
March 31, 2025 at 2:34 PM
Most pediatric patients suspected of having MCD histology are likely to respond to glucocorticoid therapy (steroid-sensitive nephrotic syndrome), but a variable proportion experience at least 1 relapse within the 1st year of disease onset:

bit.ly/NM25MCDRelapse

#NephMadness
March 31, 2025 at 2:28 PM
Childhood nephrotic syndrome is primarily classified based on its response to corticosteroid treatment. This team will discuss the most current understanding of the pathophysiological mechanisms of MCD:

bit.ly/NM25MCDdx

#NephMadness
March 31, 2025 at 2:28 PM
From interpreting variants of uncertain significance to navigating insurance implications and deciding whether to test relatives, genetic counseling helps patients and families make sense of these results and make difficult decisions:

bit.ly/NM25GeneticCounseling

#NephMadness
March 31, 2025 at 2:22 PM
We’ve all encountered patients with FSGS and asked: - Is this primary or secondary? - When should we consider genetic testing? This team explores the role of genetics in FSGS, helping us navigate when and how to test:

bit.ly/NM25GeneticsInFSGS

#NephMadness
March 31, 2025 at 2:22 PM
Here you will digest the complex information about dietary hyperoxaluria and learn what an anti-nutrient like oxalate is doing in our salad. Beware of oxalate nephropathy as it can cause or exacerbate chronic kidney disease!

#NephMadness

bit.ly/NM25OxalateOffenders
March 31, 2025 at 2:09 PM
Meet riveting plant villains, from aristolochia to licorice to colchium. Learn why kidneys are a ‘terrific toxin target’ and where to look up the most accurate information about herbal medicines.

#NephMadness

bit.ly/NM25TubularToxins
March 31, 2025 at 2:09 PM
Not sure about your #NephMadness selection?

Disagree with the group bracket decision?

You can submit 2 entries per person to increase 🏆 chances.

Go ahead and submit a Backup Bracket: bit.ly/2DvWyou
March 28, 2025 at 7:55 PM