Nick Banovich
@nebanovich.bsky.social
Associate Professor at TGen.org. Interested in genmoics, single cell and spatial transcriptomics, lung disease, and oftentimes fishing. banovichlab.org
Bulk of the lab are presenting posters today!
October 17, 2025 at 2:31 PM
Bulk of the lab are presenting posters today!
After a short *3 hour* flight delay excited to be in the air on the way to Boston for #ASHG25. Looking forward to sharing the lab's work.
October 14, 2025 at 10:05 PM
After a short *3 hour* flight delay excited to be in the air on the way to Boston for #ASHG25. Looking forward to sharing the lab's work.
So proud of @saahimall.bsky.social for crushing her comps today. She's a force in the lab and seeing her present her plan for the next few years was awesome.
#nocrumbs
#nocrumbs
August 12, 2025 at 1:18 AM
So proud of @saahimall.bsky.social for crushing her comps today. She's a force in the lab and seeing her present her plan for the next few years was awesome.
#nocrumbs
#nocrumbs
August 4, 2025 at 10:08 PM
Yesterday was the last day of @tgenresearch.bsky.social's summer internship supported by the Helios foundation. Bittersweet to say goodbye but happy to see them presenting their great work. Special congrats to Francesca, Lauren, and Yafnelt who were recognized for their outstanding presentations.
August 1, 2025 at 9:38 PM
Yesterday was the last day of @tgenresearch.bsky.social's summer internship supported by the Helios foundation. Bittersweet to say goodbye but happy to see them presenting their great work. Special congrats to Francesca, Lauren, and Yafnelt who were recognized for their outstanding presentations.
Finally, we demonstrate that blocking SPP1 in the JAK1 KO model and a mouse glioma model resulted in dramatic therapeutic improvement and broad remodeling of the suppressive TME. We are excited to push this work forward and work to improve outcomes for patients with solid tumors.
April 3, 2025 at 2:16 PM
Finally, we demonstrate that blocking SPP1 in the JAK1 KO model and a mouse glioma model resulted in dramatic therapeutic improvement and broad remodeling of the suppressive TME. We are excited to push this work forward and work to improve outcomes for patients with solid tumors.
Mimicking results from our human studies, the JAK1 KO model showed striking resistance to CAR T therapy. Again, SPP1 signaling was a dominant feature of the TME signaling in these tumors.
April 3, 2025 at 2:16 PM
Mimicking results from our human studies, the JAK1 KO model showed striking resistance to CAR T therapy. Again, SPP1 signaling was a dominant feature of the TME signaling in these tumors.
To extend these findings to other solid tumors we turned to an IFN deficient JAK1-knockout mouse model of melanoma. In this model we also found an immunosuppressive myeloid cell population emergent in the IFN deficient mice but not the WT tumors.
April 3, 2025 at 2:16 PM
To extend these findings to other solid tumors we turned to an IFN deficient JAK1-knockout mouse model of melanoma. In this model we also found an immunosuppressive myeloid cell population emergent in the IFN deficient mice but not the WT tumors.
Looking deeper at SPP1 we found increased expression is associated with broad remodeling of the myeloid compartment – including emergent immunosuppressive phenotypes, a changed metabolic profile, and a reduction in inflammatory IL/IFN signaling
April 3, 2025 at 2:16 PM
Looking deeper at SPP1 we found increased expression is associated with broad remodeling of the myeloid compartment – including emergent immunosuppressive phenotypes, a changed metabolic profile, and a reduction in inflammatory IL/IFN signaling
Our analysis found that SPP1 signaling between myeloid compartment and fibroblasts was increased in patients with worse outcomes and lower CD3 infiltration.
April 3, 2025 at 2:16 PM
Our analysis found that SPP1 signaling between myeloid compartment and fibroblasts was increased in patients with worse outcomes and lower CD3 infiltration.
Had a great visit to BWH/Harvard yesterday. Enjoyed spending the day talking fun science with the the great folks in the Channing. Thanks for the invite @asaferali.bsky.social! Had to snap a quick shot of this old add displayed on the wall highlighting how horrible tobacco companies were.
April 2, 2025 at 2:02 PM
Had a great visit to BWH/Harvard yesterday. Enjoyed spending the day talking fun science with the the great folks in the Channing. Thanks for the invite @asaferali.bsky.social! Had to snap a quick shot of this old add displayed on the wall highlighting how horrible tobacco companies were.
New lab photo(s)! First time the whole lab was together in person in ~4 years. Had the bright idea to stick us all in the freight elevator on the way down for our photo shoot.
March 25, 2025 at 10:37 PM
New lab photo(s)! First time the whole lab was together in person in ~4 years. Had the bright idea to stick us all in the freight elevator on the way down for our photo shoot.
Hey Alan, you can see that most the B cells are in T2 and C9 niche which mostly marks TLSs and Granulomas. Not surprised that we see lots of B cells here.
March 18, 2025 at 10:06 PM
Hey Alan, you can see that most the B cells are in T2 and C9 niche which mostly marks TLSs and Granulomas. Not surprised that we see lots of B cells here.
So excited that our study made the cover of Nature Genetics this month!
March 17, 2025 at 3:21 PM
So excited that our study made the cover of Nature Genetics this month!
Everything is chaos but at least I can still have a nice sunny beach vacay with my kids on their spring break...
March 11, 2025 at 9:33 PM
Everything is chaos but at least I can still have a nice sunny beach vacay with my kids on their spring break...
Distracting myself with hard physical labor. My mom had a pine beetle infestation in a stand of trees so I came up to her place to take them down and pile them up for burning.
February 9, 2025 at 3:17 AM
Distracting myself with hard physical labor. My mom had a pine beetle infestation in a stand of trees so I came up to her place to take them down and pile them up for burning.
Finally, we utilized machine learning to segment individual airspaces and sort them across a continuum of normal to most diseased. We found cell types, genes, and niches associated with this pseudotime, revealing an ordered series of events in the dysregulation of PF alveoli
February 4, 2025 at 2:11 PM
Finally, we utilized machine learning to segment individual airspaces and sort them across a continuum of normal to most diseased. We found cell types, genes, and niches associated with this pseudotime, revealing an ordered series of events in the dysregulation of PF alveoli
Both the epithelial detachment and macrophage accumulation findings were backed up with replicate samples processed with 10X Visium HD
February 4, 2025 at 2:11 PM
Both the epithelial detachment and macrophage accumulation findings were backed up with replicate samples processed with 10X Visium HD
We also found a disease-emergent niche associated with macrophage accumulation within airspaces. This was widespread across samples, in both alveoli and airways, and comprising two discrete populations: FABP4+ (alveolar) and SPP1+ (disease-associated) macrophages
February 4, 2025 at 2:11 PM
We also found a disease-emergent niche associated with macrophage accumulation within airspaces. This was widespread across samples, in both alveoli and airways, and comprising two discrete populations: FABP4+ (alveolar) and SPP1+ (disease-associated) macrophages