Nathan Roach
@natproach.bsky.social
Bad opinion haver, leftist, scientist, bioinformatics PhD, Rust lang enthusiast, Python begrudging-acceptor, in that order.
Reposted by Nathan Roach
Hire Nur!!
I try to not talk about it much but, god being unemployed for almost a full year now is exhausting and demoralizing. Throwing out applications, getting 300 pieces of advice, and seeing folks who do get hired get laid off only 6 months later. It's not great. 🫤
October 13, 2025 at 2:29 AM
Hire Nur!!
Reposted by Nathan Roach
Reposted by Nathan Roach
I really hate the term "sideloading". I preferred the original term, which was "installing software on a computer that you own"
August 25, 2025 at 9:43 PM
I really hate the term "sideloading". I preferred the original term, which was "installing software on a computer that you own"
God I wish that were me.
August 21, 2025 at 2:52 PM
God I wish that were me.
Been doing some traveling
August 7, 2025 at 6:27 PM
Been doing some traveling
Reposted by Nathan Roach
The Meselson and Stahl experiment demonstrated in 1958 that DNA replicated semi-conservatively.
Meaning, each of the two strands of DNA serves as a template for a new copy to made of the complementary strand.
Foundational finding, elegant experimental design.
Meaning, each of the two strands of DNA serves as a template for a new copy to made of the complementary strand.
Foundational finding, elegant experimental design.
July 8, 2025 at 1:49 AM
The Meselson and Stahl experiment demonstrated in 1958 that DNA replicated semi-conservatively.
Meaning, each of the two strands of DNA serves as a template for a new copy to made of the complementary strand.
Foundational finding, elegant experimental design.
Meaning, each of the two strands of DNA serves as a template for a new copy to made of the complementary strand.
Foundational finding, elegant experimental design.
Fascism looks a bit different in every country because it is a push towards return to an imagined past (and the past being imagined is different in different places), but the conspicuous consumption culture of the US and past of race segregation results in the most despicable people on earth.
Floridians are taking pictures of themselves next to the sign for their new death camp
As I've said before, giving this concentration camp a cutesy name is reprehensible
As I've said before, giving this concentration camp a cutesy name is reprehensible
July 5, 2025 at 10:33 PM
Fascism looks a bit different in every country because it is a push towards return to an imagined past (and the past being imagined is different in different places), but the conspicuous consumption culture of the US and past of race segregation results in the most despicable people on earth.
Reposted by Nathan Roach
This chart has been widely shared on here, it’s important to see the correction
June 30, 2025 at 10:25 PM
This chart has been widely shared on here, it’s important to see the correction
Reposted by Nathan Roach
centrists constantly complain about the left being insufficiently partisan and then line up behind a Democrat who handed the state Senate to Republicans and then gerrymandered the state to their benefit
June 24, 2025 at 4:11 PM
centrists constantly complain about the left being insufficiently partisan and then line up behind a Democrat who handed the state Senate to Republicans and then gerrymandered the state to their benefit
Reposted by Nathan Roach
This is a vital message: one of the larger reasons BlueSky is refreshingly free of alt-right shitlords is because in the early days we made a gentleperson’s agreement to starve these fuckos out and it worked. No likes, no quotes, no engagement. They got bored and left. Please keep the Old Ways.
June 18, 2025 at 11:17 PM
This is a vital message: one of the larger reasons BlueSky is refreshingly free of alt-right shitlords is because in the early days we made a gentleperson’s agreement to starve these fuckos out and it worked. No likes, no quotes, no engagement. They got bored and left. Please keep the Old Ways.
Reposted by Nathan Roach
Thanks to @michaelhobbes.bsky.social and Peter Shamshiri for this public service. This book has been widely celebrated by “very serious people“. The problem is that it is scientifically illiterate, and a clear case of motivated reasoning.
Episode 40: In Covid's Wake
Looking back at a pandemic that killed more than 1 million people, two political scientists bravely ask, "Could we have done even less?"
podcasts.apple.com/us/podcast/i...
Looking back at a pandemic that killed more than 1 million people, two political scientists bravely ask, "Could we have done even less?"
podcasts.apple.com/us/podcast/i...
"In Covid's Wake": Lying About… - If Books Could Kill - Apple Podcasts
Podcast Episode · If Books Could Kill · 06/17/2025 · 58m
podcasts.apple.com
June 18, 2025 at 1:27 PM
Thanks to @michaelhobbes.bsky.social and Peter Shamshiri for this public service. This book has been widely celebrated by “very serious people“. The problem is that it is scientifically illiterate, and a clear case of motivated reasoning.
Reposted by Nathan Roach
I'm trying to comment on this without being hyperbolic.
As a manager, insisting on deadlines that you and your ICs straight up don't believe are possible almost GUARANTEES that a) their work will be thrown out or completely redone and b) you will put them in danger of burning out.
As a manager, insisting on deadlines that you and your ICs straight up don't believe are possible almost GUARANTEES that a) their work will be thrown out or completely redone and b) you will put them in danger of burning out.
June 11, 2025 at 9:25 PM
I'm trying to comment on this without being hyperbolic.
As a manager, insisting on deadlines that you and your ICs straight up don't believe are possible almost GUARANTEES that a) their work will be thrown out or completely redone and b) you will put them in danger of burning out.
As a manager, insisting on deadlines that you and your ICs straight up don't believe are possible almost GUARANTEES that a) their work will be thrown out or completely redone and b) you will put them in danger of burning out.
Reposted by Nathan Roach
ish is a grep-like CLI tool that uses optimal alignment instead of exact matching.
It’s record-type aware, supporting line, FASTA, and FASTQ records.
Built in Mojo as a proof of concept for bioinformatics.
🧵1/5
It’s record-type aware, supporting line, FASTA, and FASTQ records.
Built in Mojo as a proof of concept for bioinformatics.
🧵1/5
Ish: SIMD and GPU Accelerated Local and Semi-Global Alignment as a CLI Filtering Tool https://www.biorxiv.org/content/10.1101/2025.06.04.657890v1
June 9, 2025 at 1:05 PM
ish is a grep-like CLI tool that uses optimal alignment instead of exact matching.
It’s record-type aware, supporting line, FASTA, and FASTQ records.
Built in Mojo as a proof of concept for bioinformatics.
🧵1/5
It’s record-type aware, supporting line, FASTA, and FASTQ records.
Built in Mojo as a proof of concept for bioinformatics.
🧵1/5
Reposted by Nathan Roach
Abolishing ICE is now the compromise position. These evil dickheads need to be sent to The Hague
ICE waited until a woman’s lawyer went to the restroom then dragged her away. She fainted from stress and they dragged her unconscious body into the elevator, refusing medical attention.
June 7, 2025 at 2:22 AM
Abolishing ICE is now the compromise position. These evil dickheads need to be sent to The Hague
Reposted by Nathan Roach
Are you looking for a faculty job? We are hiring in my department at Roswell Park NOW. Contact me for details as I await the formal ad. (Please RT.)
June 4, 2025 at 6:34 PM
Are you looking for a faculty job? We are hiring in my department at Roswell Park NOW. Contact me for details as I await the formal ad. (Please RT.)
Reposted by Nathan Roach
They're literally doing the meme
June 3, 2025 at 10:16 PM
They're literally doing the meme
Reposted by Nathan Roach
Unbelievably horrified by this attack in Boulder. We don’t know the full story of the attacker, but no matter what it is, let me be clear: Senseless, antisemitic attacks do not help Palestinians, Jews, or Israelis.
Committing terror attacks against people standing for hostages is disgusting.
Committing terror attacks against people standing for hostages is disgusting.
June 1, 2025 at 11:12 PM
Unbelievably horrified by this attack in Boulder. We don’t know the full story of the attacker, but no matter what it is, let me be clear: Senseless, antisemitic attacks do not help Palestinians, Jews, or Israelis.
Committing terror attacks against people standing for hostages is disgusting.
Committing terror attacks against people standing for hostages is disgusting.
Reposted by Nathan Roach
Industry friends, now is the time for MUCH more speaking out on behalf of academic colleagues under duress. Here are core open source methods that many of your products doubtlessly depend on either directly or indirectly (see en.wikipedia.org/wiki/HMMER) being abruptly defunded. Make noise.
May 29, 2025 at 2:39 PM
Industry friends, now is the time for MUCH more speaking out on behalf of academic colleagues under duress. Here are core open source methods that many of your products doubtlessly depend on either directly or indirectly (see en.wikipedia.org/wiki/HMMER) being abruptly defunded. Make noise.
Reposted by Nathan Roach
Excited to share a new update to Mumemto, scaling MUM and conserved element finding to any size pangenome! Preprint out now w/ @benlangmead.bsky.social.
Mumemto scales to the new HPRC v2 release and beyond, and can merge in future assemblies without any recomputation! 1/n
Mumemto scales to the new HPRC v2 release and beyond, and can merge in future assemblies without any recomputation! 1/n
Partitioned Multi-MUM finding for scalable pangenomics
Pangenome collections are growing to hundreds of high-quality genomes. This necessitates scalable methods for constructing pangenome alignments that can incorporate newly-sequenced assemblies. We prev...
www.biorxiv.org
May 27, 2025 at 7:35 PM
Excited to share a new update to Mumemto, scaling MUM and conserved element finding to any size pangenome! Preprint out now w/ @benlangmead.bsky.social.
Mumemto scales to the new HPRC v2 release and beyond, and can merge in future assemblies without any recomputation! 1/n
Mumemto scales to the new HPRC v2 release and beyond, and can merge in future assemblies without any recomputation! 1/n
Reposted by Nathan Roach
The attack on Harvard and its students started with an attack on Harvard's first Black president, launched by a white supremacist, with assistance from major Democratic donors, the New York Times, and the Washington Post.
May 22, 2025 at 8:44 PM
The attack on Harvard and its students started with an attack on Harvard's first Black president, launched by a white supremacist, with assistance from major Democratic donors, the New York Times, and the Washington Post.
I feel like some people think I’m too cynical about the Democratic Party but the important context is that I grew up in New York State, and not even the bit the party focuses on and so my exposure to the party machine has been spineless and terrible my entire fucking life.
serious answer is that in a one party state ambitious people who in another world might have taken a different path to power join the dominant party because that’s the only way to hold office, so you get people with awful views who are good at playing the insider game
What is it with "safe" blue states and producing utterly spineless and/or annoying politicians anyway?
May 19, 2025 at 11:32 PM
I feel like some people think I’m too cynical about the Democratic Party but the important context is that I grew up in New York State, and not even the bit the party focuses on and so my exposure to the party machine has been spineless and terrible my entire fucking life.
Reposted by Nathan Roach
A Path Forward to Save American Bio-Medical Research talkingpointsmemo.com/edblog/a-pat...
A Path Forward to Save American Bio-Medical Research
Over the past four months, I’ve spoken to dozens of biomedical researchers...
talkingpointsmemo.com
May 17, 2025 at 9:12 PM
A Path Forward to Save American Bio-Medical Research talkingpointsmemo.com/edblog/a-pat...