Nathalie Jurisch-Yaksi
@nathaliejuya.bsky.social
Biologist interested in cilia, brain, cerebrospinal fluid, choroid plexus, fishes and many more things.
Group leader at NTNU in Trondheim, Norway.
Beside science, I enjoy outdoor activities including hiking, sailing and skiing.
Group leader at NTNU in Trondheim, Norway.
Beside science, I enjoy outdoor activities including hiking, sailing and skiing.
Lunch with a view at 1590m. But no snow in November, this is pretty 😱😱😱. Let’s hope for a promising outcome of COP30 meeting in Brazil.
November 8, 2025 at 6:31 PM
Lunch with a view at 1590m. But no snow in November, this is pretty 😱😱😱. Let’s hope for a promising outcome of COP30 meeting in Brazil.
I had a blast visiting @imgprague.bsky.social in Prague. Thanks Sindija Šmite and Martina Huranova for hosting me and giving me the chance to not only share our research but also discuss about Data Management and #FAIR principles at the annual PhD conference. Thanks for your warm welcome.
September 22, 2025 at 3:52 PM
I had a blast visiting @imgprague.bsky.social in Prague. Thanks Sindija Šmite and Martina Huranova for hosting me and giving me the chance to not only share our research but also discuss about Data Management and #FAIR principles at the annual PhD conference. Thanks for your warm welcome.
Hard work pays off! Autumn in Norway 🍄🟫🍄🍄🟫 @emreyaksi.bsky.social
August 30, 2025 at 4:07 PM
Hard work pays off! Autumn in Norway 🍄🟫🍄🍄🟫 @emreyaksi.bsky.social
To investigate, we used a multidisciplinary approach combining in silico and in vivo methods in zebrafish embryos, which offer a simplified yet highly informative model of the ventricular system. Check out this photoconversion timelapse from @inyoungj88.bsky.social
August 14, 2025 at 11:37 AM
To investigate, we used a multidisciplinary approach combining in silico and in vivo methods in zebrafish embryos, which offer a simplified yet highly informative model of the ventricular system. Check out this photoconversion timelapse from @inyoungj88.bsky.social
Previous work—including from our own lab—has shown that CSF movement is regulated by a several biological processes: motile cilia, heart pulsations, body movements, and fluid secretion. Cilia, in particular, are often thought to be key drivers of CSF distribution. But is that really the case?
August 14, 2025 at 11:37 AM
Previous work—including from our own lab—has shown that CSF movement is regulated by a several biological processes: motile cilia, heart pulsations, body movements, and fluid secretion. Cilia, in particular, are often thought to be key drivers of CSF distribution. But is that really the case?
Lab representation at FENS regional meeting in Oslo. Thanks to the organizers and contributors for a wonderful meeting!
June 19, 2025 at 10:23 AM
Lab representation at FENS regional meeting in Oslo. Thanks to the organizers and contributors for a wonderful meeting!
One of the exciting part of science is to celebrate milestones! We are super proud of Fanchon, Hien, Natalia and Aurora, our 4 MSc students who successfully graduated! Congrats once again! And good luck for what is coming next!
@emreyaksi.bsky.social @inyoungj88.bsky.social @kavlintnu.bsky.social
@emreyaksi.bsky.social @inyoungj88.bsky.social @kavlintnu.bsky.social
June 13, 2025 at 8:49 AM
One of the exciting part of science is to celebrate milestones! We are super proud of Fanchon, Hien, Natalia and Aurora, our 4 MSc students who successfully graduated! Congrats once again! And good luck for what is coming next!
@emreyaksi.bsky.social @inyoungj88.bsky.social @kavlintnu.bsky.social
@emreyaksi.bsky.social @inyoungj88.bsky.social @kavlintnu.bsky.social
There will be light at the end of the tunnel
May 20, 2025 at 7:01 PM
There will be light at the end of the tunnel
Sakura time has finally come to Trondheim 🍒 🌸🍒@emreyaksi.bsky.social
May 12, 2025 at 6:57 AM
Sakura time has finally come to Trondheim 🍒 🌸🍒@emreyaksi.bsky.social
We identified to our surprise that diffusion plays a major role in distributing small proteins within the brain. See the video below showing the movement of a photoconverted secreted protein in the brain ventricle (credits to our genetic and imaging wizard @inyoungj88.bsky.social)
May 2, 2025 at 7:18 AM
We identified to our surprise that diffusion plays a major role in distributing small proteins within the brain. See the video below showing the movement of a photoconverted secreted protein in the brain ventricle (credits to our genetic and imaging wizard @inyoungj88.bsky.social)
So we wondered: how do flow patterns and motile cilia contribute to the movement of these smaller solutes in the ventricles and in the brain. We combined in silico and in vivo data in zebrafish, which has conserved, yet small ventricles, allowing live imaging and very well-defined flow patterns.
May 2, 2025 at 7:18 AM
So we wondered: how do flow patterns and motile cilia contribute to the movement of these smaller solutes in the ventricles and in the brain. We combined in silico and in vivo data in zebrafish, which has conserved, yet small ventricles, allowing live imaging and very well-defined flow patterns.
We know well by now that multiple factors contribute to CSF movement, including motile cilia, heart beat pulsations, bodily movement and secretion. Up to now, most flow analysis in ventricles have been performed on particles, which behave very differently from proteins and solutes.
May 2, 2025 at 7:18 AM
We know well by now that multiple factors contribute to CSF movement, including motile cilia, heart beat pulsations, bodily movement and secretion. Up to now, most flow analysis in ventricles have been performed on particles, which behave very differently from proteins and solutes.
Little evening stroll in our backyard. Days are getting longer and the sun is shining 🤩🌞☀️
April 15, 2025 at 5:36 PM
Little evening stroll in our backyard. Days are getting longer and the sun is shining 🤩🌞☀️
I feel extremely grateful to have this landscape to rest my mind.
April 13, 2025 at 12:16 PM
I feel extremely grateful to have this landscape to rest my mind.
Cilia has been at the center of our discussions at the spring school of our @for5547.bsky.social cilia consortium.
In total there were 26 trainees from across Europe, few PIs and our brilliant coordinator Christina Klausen.
In total there were 26 trainees from across Europe, few PIs and our brilliant coordinator Christina Klausen.
March 7, 2025 at 2:29 PM
Cilia has been at the center of our discussions at the spring school of our @for5547.bsky.social cilia consortium.
In total there were 26 trainees from across Europe, few PIs and our brilliant coordinator Christina Klausen.
In total there were 26 trainees from across Europe, few PIs and our brilliant coordinator Christina Klausen.
And we even found something that looks like a cilium in downtown Koblenz after lots of exciting science presentations and discussions on how to generate #FAIR data. @for5547.bsky.social
March 5, 2025 at 9:31 PM
And we even found something that looks like a cilium in downtown Koblenz after lots of exciting science presentations and discussions on how to generate #FAIR data. @for5547.bsky.social
Skiforholdene var kjempebra i fjellet, men med dette innlegget ønsker jeg å takke Forskningsrådet (NFR) for deres siste podkastserie som har underholdt meg under skituren og gitt innsikt i fremragende forskning i Norge.
www.forskningsradet.no/om-oss/forsk...
www.forskningsradet.no/om-oss/forsk...
February 9, 2025 at 1:53 PM
Skiforholdene var kjempebra i fjellet, men med dette innlegget ønsker jeg å takke Forskningsrådet (NFR) for deres siste podkastserie som har underholdt meg under skituren og gitt innsikt i fremragende forskning i Norge.
www.forskningsradet.no/om-oss/forsk...
www.forskningsradet.no/om-oss/forsk...
Decoding cilia signaling and function by the one and only @wachtenlab.bsky.social Thanks for delivering a fantastic #FEBS national lecture at the Norwegian bioscience society winter meeting.
January 25, 2025 at 3:24 PM
Decoding cilia signaling and function by the one and only @wachtenlab.bsky.social Thanks for delivering a fantastic #FEBS national lecture at the Norwegian bioscience society winter meeting.
and here neuronal activity in the larval zebrafish brain
January 17, 2025 at 2:00 PM
and here neuronal activity in the larval zebrafish brain
There was a problem with my videos. Hope now they are working. Here is CSF movement
January 17, 2025 at 2:00 PM
There was a problem with my videos. Hope now they are working. Here is CSF movement
Finally, we analysed astroglia since their soma are in contact with cerebrospinal fluid and they support neuronal function. We observed a major reduction in calcium activity in glial cells upon cilia paralysis.
January 17, 2025 at 1:58 PM
Finally, we analysed astroglia since their soma are in contact with cerebrospinal fluid and they support neuronal function. We observed a major reduction in calcium activity in glial cells upon cilia paralysis.
We next sought to identify the effects of cilia paralysis on brain physiology using two-photon calcium imaging. Our results revealed that motile cilia are necessary to maintain normal brain excitability in response to light stimuli.
January 17, 2025 at 1:58 PM
We next sought to identify the effects of cilia paralysis on brain physiology using two-photon calcium imaging. Our results revealed that motile cilia are necessary to maintain normal brain excitability in response to light stimuli.
Using RNA sequencing and transcriptomic analysis we found that cilia paralysis impacts mainly the expression of genes associated with ciliary motility.
January 17, 2025 at 1:58 PM
Using RNA sequencing and transcriptomic analysis we found that cilia paralysis impacts mainly the expression of genes associated with ciliary motility.
Leveraging the genetic advantages of #zebrafish, we aimed to address the function of motile cilia in the brain. By using a mutant with paralyzed motile cilia, we first showed that loss of ciliary motility does not impact brain morphology, despite leading to slightly enlarged ventricle.
January 17, 2025 at 1:58 PM
Leveraging the genetic advantages of #zebrafish, we aimed to address the function of motile cilia in the brain. By using a mutant with paralyzed motile cilia, we first showed that loss of ciliary motility does not impact brain morphology, despite leading to slightly enlarged ventricle.
It is well known that cilia contribute to CSF flow in the brain ventricles of all vertebrates (see here a video of CSF movement in zebrafish embryos from Olstad, Ringers et al, CB, 2019). Yet the function of cilia-mediated flow remains highly debated.
January 17, 2025 at 1:58 PM
It is well known that cilia contribute to CSF flow in the brain ventricles of all vertebrates (see here a video of CSF movement in zebrafish embryos from Olstad, Ringers et al, CB, 2019). Yet the function of cilia-mediated flow remains highly debated.