Natacha Comandante-Lou
@natacom.bsky.social
Postdoc @ColumbiaUniversity at the Center for Translational & Computational Neuroimmunology | systems biology, cell signaling, plasticity 🏳️🌈🇲🇴 (she/her)
Pinned
PLXNB1 and other signaling drives a pathologic astrocyte state contributing to cognitive decline in Alzheimer's Disease https://www.biorxiv.org/content/10.1101/2025.02.24.639868v1
🚀 Excited to share our latest work uncovering the cell-cell signals driving an #astrocyte state linked to cognitive decline in #Alzheimer’s 🧠✨ Huge thanks to my amazing collaborators Aiqun Li, Bin Zhang, Roland Friedel, @typlab.bsky.social, David Bennett!
#SingleCell #SpatialTranscriptomics #Glia
#SingleCell #SpatialTranscriptomics #Glia
Reposted by Natacha Comandante-Lou
New TYP lab publication led by PhD student @alexlish.bsky.social out today in @cp-cellreports.bsky.social! We present a reproducible neuron-astrocyte-microglia tri-culture model to better reproduce intercellular interactions in Alzheimer's disease. Read more here: www.cell.com/cell-reports...
Astrocyte induction of disease-associated microglia is suppressed by acute exposure to fAD neurons in human iPSC triple cultures
Lish et al. present a co-culture system of iPSC-derived human microglia, astrocytes,
and neurons to investigate intercellular communication across different environmental
and genetic contexts. Transcr...
www.cell.com
June 5, 2025 at 12:49 AM
New TYP lab publication led by PhD student @alexlish.bsky.social out today in @cp-cellreports.bsky.social! We present a reproducible neuron-astrocyte-microglia tri-culture model to better reproduce intercellular interactions in Alzheimer's disease. Read more here: www.cell.com/cell-reports...
Reposted by Natacha Comandante-Lou
Interested in #oligodendrocyte metabolism and/or #multiplesclerosis? Our paper is now at Biorxiv! We show that oligos express MCT2, the high affinity monocarboxylate transporter, well known for supplying neurons with astrocyte-derived lactate (astro-neuron lactate shuttle)👇
Monocarboxylate transporter 2 is required for the maintenance of myelin and axonal integrity by oligodendrocytes https://www.biorxiv.org/content/10.1101/2025.01.10.632306v1
January 11, 2025 at 9:25 PM
Interested in #oligodendrocyte metabolism and/or #multiplesclerosis? Our paper is now at Biorxiv! We show that oligos express MCT2, the high affinity monocarboxylate transporter, well known for supplying neurons with astrocyte-derived lactate (astro-neuron lactate shuttle)👇
Reposted by Natacha Comandante-Lou
Multi-cohort cerebrospinal fluid proteomics identifies robust molecular signatures across the Alzheimer disease continuum: Neuron www.cell.com/neuron/fullt...
March 14, 2025 at 2:37 PM
Multi-cohort cerebrospinal fluid proteomics identifies robust molecular signatures across the Alzheimer disease continuum: Neuron www.cell.com/neuron/fullt...
Reposted by Natacha Comandante-Lou
How does a brain with #Alzheimer look in the microscope? Neurons are dying, and I literally see holes in the tissue, like below. You can see microglia (🟡), brain immune cells, accumulating where the tissue disappears (hippocampus & entorhinal cortex). Additional markers: Astrocyte(🟣), pTau(🔵). 🧠🔬
March 8, 2025 at 10:04 PM
How does a brain with #Alzheimer look in the microscope? Neurons are dying, and I literally see holes in the tissue, like below. You can see microglia (🟡), brain immune cells, accumulating where the tissue disappears (hippocampus & entorhinal cortex). Additional markers: Astrocyte(🟣), pTau(🔵). 🧠🔬
Reposted by Natacha Comandante-Lou
Science is an investment that pays enormous dividends. So if you’re business-minded, it’s an offer you can’t refuse!
Here's my full speech from the Stand Up For Science rally in DC today: www.youtube.com/watch?v=eemj...
Here's my full speech from the Stand Up For Science rally in DC today: www.youtube.com/watch?v=eemj...
March 7, 2025 at 11:01 PM
Science is an investment that pays enormous dividends. So if you’re business-minded, it’s an offer you can’t refuse!
Here's my full speech from the Stand Up For Science rally in DC today: www.youtube.com/watch?v=eemj...
Here's my full speech from the Stand Up For Science rally in DC today: www.youtube.com/watch?v=eemj...
Reposted by Natacha Comandante-Lou
Microglial mechanisms drive amyloid-β clearance in immunized patients with Alzheimer’s disease @naturemedicine.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Microglial mechanisms drive amyloid-β clearance in immunized patients with Alzheimer’s disease - Nature Medicine
Spatial transcriptomics reveals distinct microglial mechanisms driving amyloid-β clearance in both passively and actively immunized patients with Alzheimer’s disease.
www.nature.com
March 6, 2025 at 11:31 PM
Microglial mechanisms drive amyloid-β clearance in immunized patients with Alzheimer’s disease @naturemedicine.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Natacha Comandante-Lou
I can’t wait to stand up for science on Friday! Join us in the DC rally or another rally in virtually any other state!
STAND UP FOR SCIENCE SPEAKER ANNOUNCEMENT! ☀️
Dr. Itai Yanai will be speaking at Stand Up for Science in D.C. on March 7th!
@itaiyanai.bsky.social
More speaker announcements coming soon, stay tuned! 👀☀️
Dr. Itai Yanai will be speaking at Stand Up for Science in D.C. on March 7th!
@itaiyanai.bsky.social
More speaker announcements coming soon, stay tuned! 👀☀️
March 6, 2025 at 12:25 AM
I can’t wait to stand up for science on Friday! Join us in the DC rally or another rally in virtually any other state!
🚀 Excited to share our latest work uncovering the cell-cell signals driving an #astrocyte state linked to cognitive decline in #Alzheimer’s 🧠✨ Huge thanks to my amazing collaborators Aiqun Li, Bin Zhang, Roland Friedel, @typlab.bsky.social, David Bennett!
#SingleCell #SpatialTranscriptomics #Glia
#SingleCell #SpatialTranscriptomics #Glia
PLXNB1 and other signaling drives a pathologic astrocyte state contributing to cognitive decline in Alzheimer's Disease https://www.biorxiv.org/content/10.1101/2025.02.24.639868v1
February 27, 2025 at 3:39 AM
🚀 Excited to share our latest work uncovering the cell-cell signals driving an #astrocyte state linked to cognitive decline in #Alzheimer’s 🧠✨ Huge thanks to my amazing collaborators Aiqun Li, Bin Zhang, Roland Friedel, @typlab.bsky.social, David Bennett!
#SingleCell #SpatialTranscriptomics #Glia
#SingleCell #SpatialTranscriptomics #Glia
Reposted by Natacha Comandante-Lou
PLXNB1 and other signaling drives a pathologic astrocyte state contributing to cognitive decline in Alzheimer's Disease https://www.biorxiv.org/content/10.1101/2025.02.24.639868v1
February 25, 2025 at 10:25 PM
PLXNB1 and other signaling drives a pathologic astrocyte state contributing to cognitive decline in Alzheimer's Disease https://www.biorxiv.org/content/10.1101/2025.02.24.639868v1