Nick Altemose
@naltemose.bsky.social
Assistant Professor of Genetics at Stanford | centromeres, heterochromatin, and long-read sequencing | 🇺🇸🇧🇴🏳️🌈 | altemoselab.stanford.edu
Reposted by Nick Altemose
A new and fascinating story from @bencarty.bsky.social and the group, with crucial help from the teams of @naltemose.bsky.social, Simona Giunta, and @dfachinetti.bsky.social. Many thanks to all for a fantastic collaboration.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 25, 2025 at 12:16 PM
A new and fascinating story from @bencarty.bsky.social and the group, with crucial help from the teams of @naltemose.bsky.social, Simona Giunta, and @dfachinetti.bsky.social. Many thanks to all for a fantastic collaboration.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Nick Altemose
📢ONLINE @natgenet.nature.com
📰DNA methylation influences human centromere positioning and function.
By Catalina Salinas-Luypaert, @dfachinetti.bsky.social, @naltemose.bsky.social and colleagues.
⬇️
www.nature.com/articles/s41...
📰DNA methylation influences human centromere positioning and function.
By Catalina Salinas-Luypaert, @dfachinetti.bsky.social, @naltemose.bsky.social and colleagues.
⬇️
www.nature.com/articles/s41...
DNA methylation influences human centromere positioning and function - Nature Genetics
Genome-wide and targeted perturbation of DNA methylation at centromeres affects CENP-A positioning and centromere structure, resulting in aneuploidy and reduced cell viability.
www.nature.com
September 5, 2025 at 12:32 PM
📢ONLINE @natgenet.nature.com
📰DNA methylation influences human centromere positioning and function.
By Catalina Salinas-Luypaert, @dfachinetti.bsky.social, @naltemose.bsky.social and colleagues.
⬇️
www.nature.com/articles/s41...
📰DNA methylation influences human centromere positioning and function.
By Catalina Salinas-Luypaert, @dfachinetti.bsky.social, @naltemose.bsky.social and colleagues.
⬇️
www.nature.com/articles/s41...
Reposted by Nick Altemose
#1 Centromeres are epigenetic loci defined by CENP-A, positioned in unmethylated DNA flanked by highly methylated regions. Our work, published in @natgenet.nature.com in collaboration with @naltemose.bsky.social investigates the role of DNAme at human centromeres www.nature.com/articles/s41...
DNA methylation influences human centromere positioning and function - Nature Genetics
Genome-wide and targeted perturbation of DNA methylation at centromeres affects CENP-A positioning and centromere structure, resulting in aneuploidy and reduced cell viability.
www.nature.com
September 4, 2025 at 1:10 PM
#1 Centromeres are epigenetic loci defined by CENP-A, positioned in unmethylated DNA flanked by highly methylated regions. Our work, published in @natgenet.nature.com in collaboration with @naltemose.bsky.social investigates the role of DNAme at human centromeres www.nature.com/articles/s41...
Are you preparing to go on the biomedical faculty job market? Do you have a track record of excellence in research, leadership, mentorship, & community engagement? Apply to the 2025 Next Generation Faculty Symposium: www.berkeleystanfordnextgensymposium.com! The deadline is May 30. Please repost!
May 27, 2025 at 5:27 PM
Are you preparing to go on the biomedical faculty job market? Do you have a track record of excellence in research, leadership, mentorship, & community engagement? Apply to the 2025 Next Generation Faculty Symposium: www.berkeleystanfordnextgensymposium.com! The deadline is May 30. Please repost!
Federal research funding not only advances healthcare and technology, but it also reliably grows the economy. These are some of the best-spent dollars in our government! Divesting from this golden goose will sacrifice future economic growth and make us all worse off. www.forbes.com/sites/johndr...
Trump’s NIH And NSF Cuts Could Cost The U.S. Economy $10 Billion Annually
Economists find public R&D drives a quarter of U.S. productivity growth — and pays for itself
www.forbes.com
May 19, 2025 at 12:44 PM
Federal research funding not only advances healthcare and technology, but it also reliably grows the economy. These are some of the best-spent dollars in our government! Divesting from this golden goose will sacrifice future economic growth and make us all worse off. www.forbes.com/sites/johndr...
Reposted by Nick Altemose
I am proud to share my first preprint working with @naltemose.bsky.social, where we redesign DiMeLo-seq from the ground up. Thankful for the help and input of collaborators in @astraight.bsky.social and Aaron streets’ lab at Berkeley. More to come soon!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
DiMeLo-cito: a one-tube protocol for mapping protein-DNA interactions reveals CTCF bookmarking in mitosis
Genome regulation relies on complex and dynamic interactions between DNA and proteins. Recently, powerful methods have emerged that leverage third-generation sequencing to map protein-DNA interactions...
www.biorxiv.org
March 14, 2025 at 9:04 PM
I am proud to share my first preprint working with @naltemose.bsky.social, where we redesign DiMeLo-seq from the ground up. Thankful for the help and input of collaborators in @astraight.bsky.social and Aaron streets’ lab at Berkeley. More to come soon!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Nick Altemose
🚨Pre-Print
Tired of losing valuable DNA-protein interaction information from your long-read seq data during wash steps?
New wash-free, one tube DiMeLo-cito protocol from @naltemose.bsky.social @astraight.bsky.social @ngamarra.bsky.social for max quality + yield!
🧪🖥️🧬 #STS
👇
doi.org/10.1101/2025...
Tired of losing valuable DNA-protein interaction information from your long-read seq data during wash steps?
New wash-free, one tube DiMeLo-cito protocol from @naltemose.bsky.social @astraight.bsky.social @ngamarra.bsky.social for max quality + yield!
🧪🖥️🧬 #STS
👇
doi.org/10.1101/2025...
DiMeLo-cito: a one-tube protocol for mapping protein-DNA interactions reveals CTCF bookmarking in mitosis
Genome regulation relies on complex and dynamic interactions between DNA and proteins. Recently, powerful methods have emerged that leverage third-generation sequencing to map protein-DNA interactions...
www.biorxiv.org
March 14, 2025 at 3:59 PM
🚨Pre-Print
Tired of losing valuable DNA-protein interaction information from your long-read seq data during wash steps?
New wash-free, one tube DiMeLo-cito protocol from @naltemose.bsky.social @astraight.bsky.social @ngamarra.bsky.social for max quality + yield!
🧪🖥️🧬 #STS
👇
doi.org/10.1101/2025...
Tired of losing valuable DNA-protein interaction information from your long-read seq data during wash steps?
New wash-free, one tube DiMeLo-cito protocol from @naltemose.bsky.social @astraight.bsky.social @ngamarra.bsky.social for max quality + yield!
🧪🖥️🧬 #STS
👇
doi.org/10.1101/2025...
Reposted by Nick Altemose
@bencarty.bsky.social and the team did a fantastic job in a wonderful collaboration with @naltemose.bsky.social as well as Dani Fachinetti and Simona Giunta’s teams to help define the molecular basis for maintaining centromeric chromatin size and position. www.biorxiv.org/content/10.1...
February 5, 2025 at 5:33 PM
@bencarty.bsky.social and the team did a fantastic job in a wonderful collaboration with @naltemose.bsky.social as well as Dani Fachinetti and Simona Giunta’s teams to help define the molecular basis for maintaining centromeric chromatin size and position. www.biorxiv.org/content/10.1...
Reposted by Nick Altemose
New conference that will explore gene regulation mechanisms at molecular resolution. We bring bring together a fine crowd that uses microscopy, genomics and theory to chart the future of the booming fields of #singlemoleculegenomics and #singlemoleculemicroscopy. Join us July 15-18th 2025 at EMBL
November 14, 2024 at 8:43 AM
New conference that will explore gene regulation mechanisms at molecular resolution. We bring bring together a fine crowd that uses microscopy, genomics and theory to chart the future of the booming fields of #singlemoleculegenomics and #singlemoleculemicroscopy. Join us July 15-18th 2025 at EMBL
Reposted by Nick Altemose
@arnaudkr.bsky.social and I have been talking about organizing a single-molecule genomics meeting for years! We're excited to do so at EMBL while bridging the fields of single-molecule genomics and microscopy with our co-organizers. Hope to see you there! July 15-18 www.embl.org/about/info/c...
November 15, 2024 at 4:50 PM
@arnaudkr.bsky.social and I have been talking about organizing a single-molecule genomics meeting for years! We're excited to do so at EMBL while bridging the fields of single-molecule genomics and microscopy with our co-organizers. Hope to see you there! July 15-18 www.embl.org/about/info/c...
Reposted by Nick Altemose
The latest from our group, led by Megan Ostrowski and @martyyang.bsky.social, is now published in final form (www.cell.com/cell/fulltex...! Many thanks to our excellent peer reviewers for suggesting several experiments (including CAF-1 perturbation) to really improve the study =) #epigenetics
The single-molecule accessibility landscape of newly replicated mammalian chromatin
By developing a long-read sequencing method to simultaneously map replication status
and protein-DNA contacts in cells, Ostrowski, Yang, et al. show that newly replicated
chromatin is enriched for unw...
www.cell.com
November 15, 2024 at 3:35 PM
The latest from our group, led by Megan Ostrowski and @martyyang.bsky.social, is now published in final form (www.cell.com/cell/fulltex...! Many thanks to our excellent peer reviewers for suggesting several experiments (including CAF-1 perturbation) to really improve the study =) #epigenetics