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#RNA #Biotechnology #ViennaRNA #ComputationalBiology
8/n

Incorporating modified bases into #RNA structure predictions can reveal striking changes in RNA functionality.

For instance, using more than 600 #tRNA sequences from tRNAdb, we've shown how modified bases significantly impact predicted structures.

#Bioinformatics #SyntheticBiology
7/n

If a loop lacks specific parameters, we substitute the unmodified counterpart as a fallback—making predictions more flexible and accurate. 🖥️

#NucleotideModifications #RNAComputing
6/n

What makes the #ViennaRNA Package unique? 🤔

We don't rely on a pre-compiled, complete set of energy parameters for modified bases. Instead, we use a mix of hard- and soft-constraints to adjust predictions where we have parameters.

#RNAScience #RNABioinformatics
5/n

Did you know? The #ViennaRNA Package can handle a wide range of RNA modifications, including:

#Inosine (I)
#Pseudouridine (P)
#N6-methyladenosine (m6A)
#7-deaza-adenosine (7DA)
#Nebularine (purine)
#Dihydrouridine (D)

#Bioinformatics #ComputationalBiology #RNAStructure #SyntheticBiology
4/n

They play vital roles in regulating gene expression by influencing processes like splicing, stability, and translation. To truly understand cellular processes and disease mechanisms, we must explore how these modifications shape RNA structure and function.

#ViennaRNA
3/n

#RNA molecules are incredibly versatile, and one way they showcase this is through post-transcriptional modifications. These modifications expand the classic four-letter RNA alphabet (A, C, G, U) to include over 300 unique bases! 🌟

#RNAResearch #RNAEditing #LifeSciences
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