Melissa Mavers, MD, PhD
@mmaversmdphd.bsky.social
Assistant Professor | Peds Stem Cell Transplant and Cell Therapies | Physician Scientist | Immune regulation of GVHD | iNKT cells | Views not medical advice (she/her)
Deeply grateful to our funding sources for this work, including the St. Baldricks Foundation and the NIH (NHLBI & NCI).
May 13, 2025 at 12:03 AM
Deeply grateful to our funding sources for this work, including the St. Baldricks Foundation and the NIH (NHLBI & NCI).
Our comprehensive analysis of human iNKT cells from multiple immunologically relevant hematologic tissues provides critical insights into their transcriptional heterogeneity and an invaluable resource for future research and development of iNKT-based therapies to optimize their safety & efficacy.
May 13, 2025 at 12:03 AM
Our comprehensive analysis of human iNKT cells from multiple immunologically relevant hematologic tissues provides critical insights into their transcriptional heterogeneity and an invaluable resource for future research and development of iNKT-based therapies to optimize their safety & efficacy.
We saw 2 transcriptionally distinct CD8+ iNKT cell populations, one naïve/precursor-like & one Th1/17/NK-like, & several distinct CD4+ populations, including a Th1/17/NK-like one. These findings suggest that CD4 & 8 expression (or lack thereof) does not always correlate with functional propensity.
May 13, 2025 at 12:03 AM
We saw 2 transcriptionally distinct CD8+ iNKT cell populations, one naïve/precursor-like & one Th1/17/NK-like, & several distinct CD4+ populations, including a Th1/17/NK-like one. These findings suggest that CD4 & 8 expression (or lack thereof) does not always correlate with functional propensity.
A combined Th1/17 transcriptional signature was detected in some human iNKT cells (verified by co-expression of Tbet & RORgt protein)--similar to human MAIT cells, yet different than mouse iNKT cells. We further uncover unique transcription factor dynamics and identify TEMRA-like iNKT cells.
May 13, 2025 at 12:03 AM
A combined Th1/17 transcriptional signature was detected in some human iNKT cells (verified by co-expression of Tbet & RORgt protein)--similar to human MAIT cells, yet different than mouse iNKT cells. We further uncover unique transcription factor dynamics and identify TEMRA-like iNKT cells.
We analyzed human iNKT cells from several immunologically relevant hematologic tissues & saw 3 main transcriptional signatures: naïve/precursor, transitional, and Th1/17/NK-like, providing new insights into iNKT development & functional potential, with similarities & differences to mouse iNKT cells.
May 13, 2025 at 12:03 AM
We analyzed human iNKT cells from several immunologically relevant hematologic tissues & saw 3 main transcriptional signatures: naïve/precursor, transitional, and Th1/17/NK-like, providing new insights into iNKT development & functional potential, with similarities & differences to mouse iNKT cells.
We analyzed human iNKT cells from several immunologically relevant hematologic tissues & saw 3 main transcriptional signatures: naïve/precursor, transitional, and Th1/17/NK-like, providing new insights into iNKT development & functional potential, with similarities & differences to mouse iNKT cells.
May 13, 2025 at 12:00 AM
We analyzed human iNKT cells from several immunologically relevant hematologic tissues & saw 3 main transcriptional signatures: naïve/precursor, transitional, and Th1/17/NK-like, providing new insights into iNKT development & functional potential, with similarities & differences to mouse iNKT cells.
This might be the coolest thing I’ve ever seen on Pubmed!
February 16, 2025 at 8:37 AM
This might be the coolest thing I’ve ever seen on Pubmed!
Oh great, thank you, and thanks for taking the time to put this together!
January 28, 2025 at 2:15 AM
Oh great, thank you, and thanks for taking the time to put this together!
Been looking for something like this, thank you! (Viewers, feel free to add me too.)
January 27, 2025 at 7:55 PM
Been looking for something like this, thank you! (Viewers, feel free to add me too.)
This gave me a chuckle I needed this morning!
January 20, 2025 at 2:51 PM
This gave me a chuckle I needed this morning!