Mingzuyu Pan
@mingzuyu-pan.bsky.social
PhD student at Szpiech lab @Penn state. Population genetics. Computational simulation. Spatial Popgen. Human genetics.
Reposted by Mingzuyu Pan
Really excited to see this work, led by Mike Grundler, published! It's a new method for inferring the geographic locations of shared genetic ancestors. In the paper, we and use it to infer the geographic history of human genetic ancestry
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
A geographic history of human genetic ancestry
Describing the distribution of genetic variation across individuals is a fundamental goal of population genetics. We present a method that capitalizes on the rich genealogical information encoded in g...
www.science.org
March 28, 2025 at 5:26 PM
Really excited to see this work, led by Mike Grundler, published! It's a new method for inferring the geographic locations of shared genetic ancestors. In the paper, we and use it to infer the geographic history of human genetic ancestry
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Mingzuyu Pan
Thrilled to have a new paper out where we use 12+ years of monitoring data to document the impacts of inbreeding on fitness in eastern massasauga rattlesnakes! www.pnas.org/doi/10.1073/...
Inbreeding reduces fitness in spatially structured populations of a threatened rattlesnake | PNAS
Small and fragmented populations are at high risk of local extinction, in part because
of elevated inbreeding and subsequent inbreeding depression....
www.pnas.org
August 20, 2025 at 4:12 AM
Thrilled to have a new paper out where we use 12+ years of monitoring data to document the impacts of inbreeding on fitness in eastern massasauga rattlesnakes! www.pnas.org/doi/10.1073/...
Reposted by Mingzuyu Pan
Excited for our publication on how the geographic scale of a sample affects the discovery of rare, deleterious variants to be out this week. With a mix of theory, simulation, and data analysis, we show when samples are narrow vs broad, the number of variants discovered and their frequencies change
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
June 5, 2025 at 5:55 PM
Excited for our publication on how the geographic scale of a sample affects the discovery of rare, deleterious variants to be out this week. With a mix of theory, simulation, and data analysis, we show when samples are narrow vs broad, the number of variants discovered and their frequencies change
Reposted by Mingzuyu Pan
I am thrilled to share this paper outlining some ideas I’ve been thinking about for a little while on a simple but powerful approach for predicting risk of inbreeding depression from long runs of homozygosity and non-ROH heterozygosity. 1/n @klohmueller.bsky.social doi.org/10.1016/j.tr...
August 4, 2025 at 5:10 PM
I am thrilled to share this paper outlining some ideas I’ve been thinking about for a little while on a simple but powerful approach for predicting risk of inbreeding depression from long runs of homozygosity and non-ROH heterozygosity. 1/n @klohmueller.bsky.social doi.org/10.1016/j.tr...