We found that bone marrow myeloid cells were enriched for IFN-γ signaling and the downstream IL-10 receptor, thereby priming myeloid cells for IL-10-mediated immunosuppression in metastatic lesions. This reveals how tumors reprogram the bone marrow to create a permissive premetastatic niche.
November 10, 2025 at 5:59 PM
We found that bone marrow myeloid cells were enriched for IFN-γ signaling and the downstream IL-10 receptor, thereby priming myeloid cells for IL-10-mediated immunosuppression in metastatic lesions. This reveals how tumors reprogram the bone marrow to create a permissive premetastatic niche.
We found that bone marrow myeloid cells were enriched for IFN-γ signaling, priming them for IL-10–mediated immunosuppression in metastatic lesions.
This reveals how tumors reprogram the bone marrow to create a permissive premetastatic niche.
This reveals how tumors reprogram the bone marrow to create a permissive premetastatic niche.
August 29, 2025 at 1:18 PM
We found that bone marrow myeloid cells were enriched for IFN-γ signaling, priming them for IL-10–mediated immunosuppression in metastatic lesions.
This reveals how tumors reprogram the bone marrow to create a permissive premetastatic niche.
This reveals how tumors reprogram the bone marrow to create a permissive premetastatic niche.