Wouter Meuleman
@meuleman.bsky.social
Affiliate Associate Professor @ UW.
Previously @ Altius Institute (Principal Investigator), @csail.mit.edu (postdoc), @nkinl.bsky.social / @tudelfteemcs.bsky.social (PhD).
Loves a good analogy!
Previously @ Altius Institute (Principal Investigator), @csail.mit.edu (postdoc), @nkinl.bsky.social / @tudelfteemcs.bsky.social (PhD).
Loves a good analogy!
We've Open Sourced all code, including the genome browser (@alexreynolds.bsky.social):
github.com/meuleman/epi...
...as well as the software to generate epilogos tracks of your own data:
github.com/meuleman/epi...
(or just run `pip install epilogos`)
github.com/meuleman/epi...
...as well as the software to generate epilogos tracks of your own data:
github.com/meuleman/epi...
(or just run `pip install epilogos`)
September 10, 2025 at 9:09 AM
We've Open Sourced all code, including the genome browser (@alexreynolds.bsky.social):
github.com/meuleman/epi...
...as well as the software to generate epilogos tracks of your own data:
github.com/meuleman/epi...
(or just run `pip install epilogos`)
github.com/meuleman/epi...
...as well as the software to generate epilogos tracks of your own data:
github.com/meuleman/epi...
(or just run `pip install epilogos`)
In addition to human data from Roadmap Epigenomics (2015, 127 biosamples) and EpiMap (2021, 833 biosamples), we now also include data from the International Human Epigenome Consortium across a whopping 1698 biosamples:
September 10, 2025 at 9:09 AM
In addition to human data from Roadmap Epigenomics (2015, 127 biosamples) and EpiMap (2021, 833 biosamples), we now also include data from the International Human Epigenome Consortium across a whopping 1698 biosamples:
Visualization of thousands of genome-wide tracks in conventional genome browsers is an absolute pain, so we developed our own on top of higlass.
Our browser provides easy access to the features described above, and offers functionality for exporting figures and data.
Our browser provides easy access to the features described above, and offers functionality for exporting figures and data.
September 10, 2025 at 9:09 AM
Visualization of thousands of genome-wide tracks in conventional genome browsers is an absolute pain, so we developed our own on top of higlass.
Our browser provides easy access to the features described above, and offers functionality for exporting figures and data.
Our browser provides easy access to the features described above, and offers functionality for exporting figures and data.
We observe a lot of stereotypical patterning across the genome, and so we implemented a basic pattern matching and search algorithm.
Think of it as a (rudimentary) genomic recommender system -- given a region of interest, identify others like it:
Think of it as a (rudimentary) genomic recommender system -- given a region of interest, identify others like it:
September 10, 2025 at 9:09 AM
We observe a lot of stereotypical patterning across the genome, and so we implemented a basic pattern matching and search algorithm.
Think of it as a (rudimentary) genomic recommender system -- given a region of interest, identify others like it:
Think of it as a (rudimentary) genomic recommender system -- given a region of interest, identify others like it:
Over the years, we've added many features, including the ability to compare groups of different cell types of biosamples.
For example, shown here for Male versus Female donors (many more examples in the paper and online):
For example, shown here for Male versus Female donors (many more examples in the paper and online):
September 10, 2025 at 9:09 AM
Over the years, we've added many features, including the ability to compare groups of different cell types of biosamples.
For example, shown here for Male versus Female donors (many more examples in the paper and online):
For example, shown here for Male versus Female donors (many more examples in the paper and online):
In this work, we aimed to simplify the interpretation and visualization of large amounts of genome-wide annotation data.
Using simple information theoretic methods, we summarize complex multi-factor data across (thousands of) biosamples into a single interpretable genomic track:
Using simple information theoretic methods, we summarize complex multi-factor data across (thousands of) biosamples into a single interpretable genomic track:
September 10, 2025 at 9:09 AM
In this work, we aimed to simplify the interpretation and visualization of large amounts of genome-wide annotation data.
Using simple information theoretic methods, we summarize complex multi-factor data across (thousands of) biosamples into a single interpretable genomic track:
Using simple information theoretic methods, we summarize complex multi-factor data across (thousands of) biosamples into a single interpretable genomic track:
The best moment to put this out there was 10 years ago, the second best moment is right now :-)
"Epilogos: information-theoretic navigation of multi-tissue functional genomic annotations"
"Epilogos: information-theoretic navigation of multi-tissue functional genomic annotations"
September 10, 2025 at 9:09 AM
The best moment to put this out there was 10 years ago, the second best moment is right now :-)
"Epilogos: information-theoretic navigation of multi-tissue functional genomic annotations"
"Epilogos: information-theoretic navigation of multi-tissue functional genomic annotations"
After nine years at the Altius Institute for Biomedical Sciences, I’ve decided it’s time to move on.
For the past two-plus years I’ve been nine hours ahead in the Netherlands. The calendars usually lined up, but life and sleep rarely did － so I’ve reset the clock.
For the past two-plus years I’ve been nine hours ahead in the Netherlands. The calendars usually lined up, but life and sleep rarely did － so I’ve reset the clock.
July 4, 2025 at 12:18 PM
After nine years at the Altius Institute for Biomedical Sciences, I’ve decided it’s time to move on.
For the past two-plus years I’ve been nine hours ahead in the Netherlands. The calendars usually lined up, but life and sleep rarely did － so I’ve reset the clock.
For the past two-plus years I’ve been nine hours ahead in the Netherlands. The calendars usually lined up, but life and sleep rarely did － so I’ve reset the clock.
New paper out in @cp-cellsystems.bsky.social in collaboration with the lab of Georg Seelig at UW, and led by the awesome Chris Yin and @castillohair.bsky.social
Using a variety of deep-learning models, we design synthetic enhancer elements:
Using a variety of deep-learning models, we design synthetic enhancer elements:
June 19, 2025 at 2:24 PM
New paper out in @cp-cellsystems.bsky.social in collaboration with the lab of Georg Seelig at UW, and led by the awesome Chris Yin and @castillohair.bsky.social
Using a variety of deep-learning models, we design synthetic enhancer elements:
Using a variety of deep-learning models, we design synthetic enhancer elements: