Megan E. Kelley, PhD
@meganekelley.bsky.social
Postdoc at Sloan Kettering Institute in http://sfeirlab.com | former Kapoor Laboratory at RU | interested in #CancerBiology #DNARepair #DrugResistance #Mitosis | opinions my own | she/her
Reposted by Megan E. Kelley, PhD
📢 SIGN & SHARE THE PETITION! 📢
New York needs an Empire Biomedical Research Institute to create new statewide funding opportunities for scientists & physician-scientists so that patients and their families get the life-saving and life-changing new therapeutics they're hoping for ✏️ c.org/TDMy2H9JTW
New York needs an Empire Biomedical Research Institute to create new statewide funding opportunities for scientists & physician-scientists so that patients and their families get the life-saving and life-changing new therapeutics they're hoping for ✏️ c.org/TDMy2H9JTW
Sign the Petition
Support a New York State Biomedical Institute for a Healthier, More Affordable Future
c.org
November 24, 2025 at 3:53 PM
📢 SIGN & SHARE THE PETITION! 📢
New York needs an Empire Biomedical Research Institute to create new statewide funding opportunities for scientists & physician-scientists so that patients and their families get the life-saving and life-changing new therapeutics they're hoping for ✏️ c.org/TDMy2H9JTW
New York needs an Empire Biomedical Research Institute to create new statewide funding opportunities for scientists & physician-scientists so that patients and their families get the life-saving and life-changing new therapeutics they're hoping for ✏️ c.org/TDMy2H9JTW
Reposted by Megan E. Kelley, PhD
As part of our National Postdoc Appreciation Week tradition, we are celebrating our remarkable #MSKPostdocs with social cards & profiles! 🎉🙌 Stay tuned over the next two weeks to meet the outstanding scientists driving innovation at @mskcancercenter.bsky.social💡🧬🥼👩🔬👨🔬 #NPAW2025
September 16, 2025 at 3:53 PM
As part of our National Postdoc Appreciation Week tradition, we are celebrating our remarkable #MSKPostdocs with social cards & profiles! 🎉🙌 Stay tuned over the next two weeks to meet the outstanding scientists driving innovation at @mskcancercenter.bsky.social💡🧬🥼👩🔬👨🔬 #NPAW2025
Reposted by Megan E. Kelley, PhD
Well don't I feel stupid
September 26, 2025 at 11:02 PM
Well don't I feel stupid
It was an honor to have made it to the Postdoc SLAM finals and I'm thrilled to have earned 2nd place! The entire lineup was amazing. Thank you @mskeducation.bsky.social for kicking off #NPAW with such a great event and many thanks to our audience and judges for coming out to support science at MSK
🎉 Congratulations to our 10 MSK Postdoc Slam finalists! 👏 You were all fantastic and it was truly inspiring to learn about the incredible and diverse work happening at @mskcancercenter.bsky.social. Our #MSKPostdocs gave the judges a real challenge… choosing winners was no easy task! 🤗 #NPAW2025
September 16, 2025 at 1:32 AM
It was an honor to have made it to the Postdoc SLAM finals and I'm thrilled to have earned 2nd place! The entire lineup was amazing. Thank you @mskeducation.bsky.social for kicking off #NPAW with such a great event and many thanks to our audience and judges for coming out to support science at MSK
Reposted by Megan E. Kelley, PhD
It’s SHOW TIME! 🎤 Kicking off the MSK Postdoc Slam is @meganekelley.bsky.social from the @agnelsfeir.bsky.social lab, diving into how error-prone DNA repair fuels drug resistance in cancer 🧬💊
September 15, 2025 at 8:09 PM
It’s SHOW TIME! 🎤 Kicking off the MSK Postdoc Slam is @meganekelley.bsky.social from the @agnelsfeir.bsky.social lab, diving into how error-prone DNA repair fuels drug resistance in cancer 🧬💊
Reposted by Megan E. Kelley, PhD
Wild side note on medical research: 1 million people is a lot of people to have in a study. Denmark can do it because, more than a country, it's a continuous natural experiment of every healthcare issue.
The public healthcare system keeps unusually easy to cross reference databases of its users.
The public healthcare system keeps unusually easy to cross reference databases of its users.
Yet another study (Danish) has found no association between aluminum in childhood vaccines & 50 different health conditions, including autism, asthma & autoimmune diseases. In this study, they tracked 1 million kids over 21 years.
🧪🔗 en.ssi.dk/news/news/20...
🧪🔗 en.ssi.dk/news/news/20...
Large Danish Study: No link between vaccines and autism or 49 other health conditions
A new Danish study finds no association between aluminum in childhood vaccines and 50 different health conditions, including autism, asthma, and autoimmune diseases. The findings reaffirm the safety o...
en.ssi.dk
July 29, 2025 at 12:51 AM
Wild side note on medical research: 1 million people is a lot of people to have in a study. Denmark can do it because, more than a country, it's a continuous natural experiment of every healthcare issue.
The public healthcare system keeps unusually easy to cross reference databases of its users.
The public healthcare system keeps unusually easy to cross reference databases of its users.
Reposted by Megan E. Kelley, PhD
If you're a scientist or interested in science, it's well worth listening to Tom Lehrer's "The Elements" (sung by the author) in his honor (especially the last line 😉) 🧪
en.wikipedia.org/wiki/The_Ele...
en.wikipedia.org/wiki/The_Ele...
The Elements (song) - Wikipedia
en.wikipedia.org
July 28, 2025 at 12:05 AM
If you're a scientist or interested in science, it's well worth listening to Tom Lehrer's "The Elements" (sung by the author) in his honor (especially the last line 😉) 🧪
en.wikipedia.org/wiki/The_Ele...
en.wikipedia.org/wiki/The_Ele...
Reposted by Megan E. Kelley, PhD
Lamenting our microscopes aren't hooked up for sound..
Soooooo… Nematostella fart.
That is what you are telling me?
That is what you are telling me?
We thought we were just studying mesoglea biogenesis…Turns out Nematostella has been hiding a sophisticated backup pressure valve! Work driven by the talented PhD student Soham Basu! @embl.org www.biorxiv.org/content/10.1...
May 28, 2025 at 2:43 PM
Lamenting our microscopes aren't hooked up for sound..
Reposted by Megan E. Kelley, PhD
On the first day of the conference, find the biggest, most senior professor, and punch him directly in the face
This week in my graduate-level Science Communication class, we're discussing scientific conferences, including how to find a conference that's helpful for you, how to make the most of attending a conference, networking, and effective presentation skills.
Anyone have any advice to share? 🧪🦑🌎
Anyone have any advice to share? 🧪🦑🌎
May 28, 2025 at 12:58 AM
On the first day of the conference, find the biggest, most senior professor, and punch him directly in the face
Reposted by Megan E. Kelley, PhD
Interesting opinion in Science suggesting to replace 'scientific consensus' with convergent evidence.
Because it is less easily derailed by quoting one dissenting opinion.
Seems like a good idea!
www.science.org/doi/10.1126/...
Because it is less easily derailed by quoting one dissenting opinion.
Seems like a good idea!
www.science.org/doi/10.1126/...
Convergence and consensus
In these days of political instability, geopolitical tensions, and social discontent around the world, there are continued threats to the principles, conduct, and findings of science. This assault on ...
www.science.org
April 25, 2025 at 6:58 AM
Interesting opinion in Science suggesting to replace 'scientific consensus' with convergent evidence.
Because it is less easily derailed by quoting one dissenting opinion.
Seems like a good idea!
www.science.org/doi/10.1126/...
Because it is less easily derailed by quoting one dissenting opinion.
Seems like a good idea!
www.science.org/doi/10.1126/...
Reposted by Megan E. Kelley, PhD
The Science I Would Be Doing if I Weren’t in ICE Detention
By Kseniia Petrova
"Ms. Petrova is a Russian scientist who works in a lab at Harvard Medical School. She told her story through a Times Opinion editor, Alex Ellerbeck, over multiple calls from an ICE detention center."
By Kseniia Petrova
"Ms. Petrova is a Russian scientist who works in a lab at Harvard Medical School. She told her story through a Times Opinion editor, Alex Ellerbeck, over multiple calls from an ICE detention center."
Opinion | The Science I Would Be Doing if I Weren’t in ICE Detention
www.nytimes.com
May 13, 2025 at 12:20 PM
The Science I Would Be Doing if I Weren’t in ICE Detention
By Kseniia Petrova
"Ms. Petrova is a Russian scientist who works in a lab at Harvard Medical School. She told her story through a Times Opinion editor, Alex Ellerbeck, over multiple calls from an ICE detention center."
By Kseniia Petrova
"Ms. Petrova is a Russian scientist who works in a lab at Harvard Medical School. She told her story through a Times Opinion editor, Alex Ellerbeck, over multiple calls from an ICE detention center."
Reposted by Megan E. Kelley, PhD
New preprint from the lab led by Yanyang Chen identifies BAF as a key regulator of TREX1 activity at micronuclei.
ER-tethering directs TREX1 penetration of a BAF-dependent barrier at micronuclei https://www.biorxiv.org/content/10.1101/2025.04.14.648782v1
April 16, 2025 at 11:39 AM
New preprint from the lab led by Yanyang Chen identifies BAF as a key regulator of TREX1 activity at micronuclei.
Reposted by Megan E. Kelley, PhD
US students. Looking to apply to graduate school? Had an offer rescinded recently? The University of British Columbia in Canada will re-open the application portal in some departments for US students from April 14-18.
Details: www.grad.ubc.ca/us-applicant...
#ubc #AcademicSky #PhDSky #ScienceSky
Details: www.grad.ubc.ca/us-applicant...
#ubc #AcademicSky #PhDSky #ScienceSky
US Applicant Week
www.grad.ubc.ca
April 11, 2025 at 7:03 PM
US students. Looking to apply to graduate school? Had an offer rescinded recently? The University of British Columbia in Canada will re-open the application portal in some departments for US students from April 14-18.
Details: www.grad.ubc.ca/us-applicant...
#ubc #AcademicSky #PhDSky #ScienceSky
Details: www.grad.ubc.ca/us-applicant...
#ubc #AcademicSky #PhDSky #ScienceSky
Reposted by Megan E. Kelley, PhD
I am a Biology Section leader for @aaas.org. I have one-year, complimentary student memberships to AAAS for undergrads, grads, and postdocs. If interested, please DM me.
AAAS has 100,000+ members and is a major advocacy group for science, which is critical now. AAAS publishes the journal Science.
AAAS has 100,000+ members and is a major advocacy group for science, which is critical now. AAAS publishes the journal Science.
a woman in a red dress holds a microphone and says you get one and you get one we all get one
Alt: a woman (Oprah Winfrey) in a red dress holds a microphone and says you get one and you get one we all get one
media.tenor.com
April 2, 2025 at 5:52 PM
I am a Biology Section leader for @aaas.org. I have one-year, complimentary student memberships to AAAS for undergrads, grads, and postdocs. If interested, please DM me.
AAAS has 100,000+ members and is a major advocacy group for science, which is critical now. AAAS publishes the journal Science.
AAAS has 100,000+ members and is a major advocacy group for science, which is critical now. AAAS publishes the journal Science.
Reposted by Megan E. Kelley, PhD
Countdown to an epic new pre-print.
Mitochondria are cells within our cells. They need the same core activities - replication, transcription, translation. How do cells enable these diverse activities in both compartments? We uncover an unexpected + broad strategy with ancient origins. Stay tuned!
Mitochondria are cells within our cells. They need the same core activities - replication, transcription, translation. How do cells enable these diverse activities in both compartments? We uncover an unexpected + broad strategy with ancient origins. Stay tuned!
March 25, 2025 at 10:35 AM
Countdown to an epic new pre-print.
Mitochondria are cells within our cells. They need the same core activities - replication, transcription, translation. How do cells enable these diverse activities in both compartments? We uncover an unexpected + broad strategy with ancient origins. Stay tuned!
Mitochondria are cells within our cells. They need the same core activities - replication, transcription, translation. How do cells enable these diverse activities in both compartments? We uncover an unexpected + broad strategy with ancient origins. Stay tuned!
Reposted by Megan E. Kelley, PhD
Happy to have contributed a small part to this exciting story about the ancestors of eukaryotic tubulin in Asgard archaea. Congratulations to all the co-authors!
Asgard archaea have actin - but what about microtubules? Where do they come from? 🧐 Our new paper www.cell.com/cell/fulltex... by @xujwet.bsky.social & @florianwollweber.bsky.social, in collaboration with the Schleper & Wieczorek labs, describes tiny Asgard microtubules! #TeamTomo #ArchaeaSky 1/6
March 22, 2025 at 8:02 AM
Happy to have contributed a small part to this exciting story about the ancestors of eukaryotic tubulin in Asgard archaea. Congratulations to all the co-authors!
Reposted by Megan E. Kelley, PhD
1/ Transposable elements are often called "jumping genes" because they mobilize within genomes. 🧬
But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯
Our new study reveals how retrotransposons invade the germline directly from somatic cells.
www.biorxiv.org/content/10.1...
A short thread 🧵👇
But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯
Our new study reveals how retrotransposons invade the germline directly from somatic cells.
www.biorxiv.org/content/10.1...
A short thread 🧵👇
March 17, 2025 at 11:56 AM
1/ Transposable elements are often called "jumping genes" because they mobilize within genomes. 🧬
But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯
Our new study reveals how retrotransposons invade the germline directly from somatic cells.
www.biorxiv.org/content/10.1...
A short thread 🧵👇
But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯
Our new study reveals how retrotransposons invade the germline directly from somatic cells.
www.biorxiv.org/content/10.1...
A short thread 🧵👇
Reposted by Megan E. Kelley, PhD
In the midst of all the NIH & NSF chaos, I want to take a moment to focus on some good news and talk about science! 🧬✨
🚨 New preprint alert! 🚨 doi.org/10.1101/2025...
🧵👇 (1/)
🚨 New preprint alert! 🚨 doi.org/10.1101/2025...
🧵👇 (1/)
doi.org
February 27, 2025 at 3:15 AM
In the midst of all the NIH & NSF chaos, I want to take a moment to focus on some good news and talk about science! 🧬✨
🚨 New preprint alert! 🚨 doi.org/10.1101/2025...
🧵👇 (1/)
🚨 New preprint alert! 🚨 doi.org/10.1101/2025...
🧵👇 (1/)
Reposted by Megan E. Kelley, PhD
Please check out our preprint where we find that mitotic transcription helps ensure ecDNA inheritance through chromosomal tethering:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
February 17, 2025 at 11:04 AM
Please check out our preprint where we find that mitotic transcription helps ensure ecDNA inheritance through chromosomal tethering:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Megan E. Kelley, PhD
Taking pictures of cells with a microscope, then extracting thousands of features from them is uncannily effective for quantifying cell state, esp. for genes and chemicals (e.g., Cell Painting). But we often average the rich single-cell data to simplify analysis. Can we do better?
#bioML 🧪
1/n
#bioML 🧪
1/n
![(a) Human U2OS cells treated with dimethyl sulfoxide (DMSO) and stained using the Cell Painting assay, which employs six dyes in five channels to label eight cellular compartments. The top row (from left to right) shows mitochondrial staining; actin, Golgi, and plasma membrane staining; and nucleolar and cytoplasmic RNA staining. The bottom row (from left to right) displays endoplasmic reticulum staining, DNA staining, and a montage of all five channels (from Cimini et al. [21]). (b) Thousands of features are extracted from each segmented cell in microscopy images of wells. A learned function f(x) (CytoSummaryNet) aggregates this data into a single feature vector: the sample’s profile. (c) An in-depth look at the model architecture used in this study. The model consists of three elements: a function φ(x), which maps the input data from ℝD to ℝL space, a summation, which collapses the cell dimension, and ρ(z), which maps the collapsed representation from ℝN to ℝL space. (d) During training, replicate compound profiles are forced to attract each other (green arrows) and simultaneously repel every other compound (red arrows) in the learned feature space. Here, all forces are drawn for a single profile of compound B.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:raswr6mjt7sbppdo6kcce4mz/bafkreicppuq2utmxkx5kpaggndigq7qcat6ppdqqajxhphpyi53ydlbbeq@jpeg)
December 19, 2024 at 11:31 PM
Taking pictures of cells with a microscope, then extracting thousands of features from them is uncannily effective for quantifying cell state, esp. for genes and chemicals (e.g., Cell Painting). But we often average the rich single-cell data to simplify analysis. Can we do better?
#bioML 🧪
1/n
#bioML 🧪
1/n
Reposted by Megan E. Kelley, PhD
Do you love science and want research experience before your next step? NY-RaMP is a 1 year paid opportunity for recent college graduates to do research in my lab or another lab at Hunter College. Learn more at a free webinar on Wed Dec 11 at 3 PM EST nyramp.org/webinars
December 9, 2024 at 2:14 PM
Do you love science and want research experience before your next step? NY-RaMP is a 1 year paid opportunity for recent college graduates to do research in my lab or another lab at Hunter College. Learn more at a free webinar on Wed Dec 11 at 3 PM EST nyramp.org/webinars
Reposted by Megan E. Kelley, PhD
Super excited for my first day as Assistant Prof at @cuanschutz.bsky.social in the Dept of Pharmacology! The lab is open, and now I can't wait to do exciting science! #FirstGen #newPI #STEM #AcademicLife #ExcitingScience #PhDLife #WomenInSTEM #MomInSTEM #GenomeStability #CellBiology #DNARepair
December 2, 2024 at 11:41 PM
Super excited for my first day as Assistant Prof at @cuanschutz.bsky.social in the Dept of Pharmacology! The lab is open, and now I can't wait to do exciting science! #FirstGen #newPI #STEM #AcademicLife #ExcitingScience #PhDLife #WomenInSTEM #MomInSTEM #GenomeStability #CellBiology #DNARepair
Reposted by Megan E. Kelley, PhD
When I will respond to your email
November 20, 2024 at 6:38 PM
When I will respond to your email
Reposted by Megan E. Kelley, PhD
Hey, does anyone have any tips on how to analyze a truck load of single cell calcium imaging data?
I was thinking of clustering, but it feels off somehow.
Pointers, pubs, appreciated!
I was thinking of clustering, but it feels off somehow.
Pointers, pubs, appreciated!
November 18, 2024 at 2:10 PM
Hey, does anyone have any tips on how to analyze a truck load of single cell calcium imaging data?
I was thinking of clustering, but it feels off somehow.
Pointers, pubs, appreciated!
I was thinking of clustering, but it feels off somehow.
Pointers, pubs, appreciated!