Meagan Phelan
@meagan-g-phelan.bsky.social
Curious human. Communications Director at the Science family of journals. Interested in what makes good leaders—& good jokes.
Reposted by Meagan Phelan
The team is already working to expand the platform’s abilities, including testing in clinically relevant immune and stem cells, and engineering future versions of the system that can rearrange sequences beyond one megabase.
Learn more in the full paper: www.science.org/doi/10.1126/...
Learn more in the full paper: www.science.org/doi/10.1126/...
Megabase-scale human genome rearrangement with programmable bridge recombinases
Bridge recombinases are naturally occurring RNA-guided DNA recombinases that we previously demonstrated can programmably insert, excise, and invert DNA in vitro and in Escherichia coli. In this study,...
www.science.org
September 25, 2025 at 6:27 PM
The team is already working to expand the platform’s abilities, including testing in clinically relevant immune and stem cells, and engineering future versions of the system that can rearrange sequences beyond one megabase.
Learn more in the full paper: www.science.org/doi/10.1126/...
Learn more in the full paper: www.science.org/doi/10.1126/...
Reposted by Meagan Phelan
🌉 Patrick Hsu’s Lab reports the discovery and engineering of the bridge recombinase ortholog ISCro4 for universal rearrangements of the human genome.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Megabase-scale human genome rearrangement with programmable bridge recombinases
Bridge recombinases are naturally occurring RNA-guided DNA recombinases that we previously demonstrated can programmably insert, excise, and invert DNA in vitro and in Escherichia coli. In this study,...
www.science.org
October 2, 2025 at 1:45 PM
🌉 Patrick Hsu’s Lab reports the discovery and engineering of the bridge recombinase ortholog ISCro4 for universal rearrangements of the human genome.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Meagan Phelan
yep - and in some ways Science did this with the technical comments. but none of this is evident in the citation, PubMed record, search result, PDF, etc. unless the paper is formally retracted
July 27, 2025 at 4:12 PM
yep - and in some ways Science did this with the technical comments. but none of this is evident in the citation, PubMed record, search result, PDF, etc. unless the paper is formally retracted