Michael Dannemann
@mdannemann.bsky.social
Associate Professor of Evolutionary Genomics
Centre for Genomics, Evolution and Medicine
Institute of Genomics, University of Tartu
Centre for Genomics, Evolution and Medicine
Institute of Genomics, University of Tartu
Reposted by Michael Dannemann
We are excited to share GPN-Star, a cost-effective, biologically grounded genomic language modeling framework that achieves state-of-the-art performance across a wide range of variant effect prediction tasks relevant to human genetics.
www.biorxiv.org/content/10.1...
(1/n)
www.biorxiv.org/content/10.1...
(1/n)
September 22, 2025 at 5:29 AM
We are excited to share GPN-Star, a cost-effective, biologically grounded genomic language modeling framework that achieves state-of-the-art performance across a wide range of variant effect prediction tasks relevant to human genetics.
www.biorxiv.org/content/10.1...
(1/n)
www.biorxiv.org/content/10.1...
(1/n)
Reposted by Michael Dannemann
In my latest, I look at one of the main components of immune system variation, the HLA system, and what today’s people have inherited from the archaic peoples of East and island Southeast Asia that we know as today as Denisovans.
www.johnhawks.net/p/denisovan-...
www.johnhawks.net/p/denisovan-...
Denisovan HLA and its role in immunity
Today's people have inherited several immune alleles from archaic people. Understanding what difference they made is a continuing challenge.
www.johnhawks.net
August 11, 2025 at 5:41 PM
In my latest, I look at one of the main components of immune system variation, the HLA system, and what today’s people have inherited from the archaic peoples of East and island Southeast Asia that we know as today as Denisovans.
www.johnhawks.net/p/denisovan-...
www.johnhawks.net/p/denisovan-...
Reposted by Michael Dannemann
Interested in how ancient genomes are providing insights into the our evolutionary past? @pontus-skoglund.bsky.social and I are excited about the great program coming together for this meeting in London in November! Register now to join us!
We’ve got some good news! The deadline to submit abstracts for our “Ancient #Genomes: Perspectives on Human Biology and Medicine” meeting has been extended to 31 July 2025. So if you were thinking about submitting, there’s still plenty of time!
genetics.org.uk/events/ancie...
genetics.org.uk/events/ancie...
Ancient genomes: perspectives on human biology and medicine | Genetics Society
It is our great pleasure to invite you to participate in the Autumn Meeting of the Genetics Society. This meeting will provide a unique forum to network and socialise with a wide cross-section of the ...
genetics.org.uk
July 2, 2025 at 7:52 AM
Interested in how ancient genomes are providing insights into the our evolutionary past? @pontus-skoglund.bsky.social and I are excited about the great program coming together for this meeting in London in November! Register now to join us!
Reposted by Michael Dannemann
🎉 This paper has been a long time and a labour of love (and hardship) for multiple group members, but, finally: we MPRA'ed 25k introgressed variants (Denisovan and Neanderthal) segregating at allele frequencies > 0.15 in humans today to evaluate their potential to regulate gene expression.
Mapping the gene regulatory landscape of archaic hominin introgression in modern Papuans https://www.biorxiv.org/content/10.1101/2025.05.04.652069v1
May 5, 2025 at 2:43 AM
🎉 This paper has been a long time and a labour of love (and hardship) for multiple group members, but, finally: we MPRA'ed 25k introgressed variants (Denisovan and Neanderthal) segregating at allele frequencies > 0.15 in humans today to evaluate their potential to regulate gene expression.