Mcclelland lab
@mcclellandlab.bsky.social
Investigating origins and vulnerabilities of cancer chromosomal instability at the Barts Cancer Institute, London UK. Www.Mcclellandlab.com
Reposted by Mcclelland lab
Ready to start your own independent research programme?
We're inviting applications for early career group leaders in all areas of biology and biomedicine @crick.ac.uk
Apply by 27 Nov 2025:
www.crick.ac.uk/careers-stud...
#EarlyCareerResearchers #GroupLeader #ScienceCareers
We're inviting applications for early career group leaders in all areas of biology and biomedicine @crick.ac.uk
Apply by 27 Nov 2025:
www.crick.ac.uk/careers-stud...
#EarlyCareerResearchers #GroupLeader #ScienceCareers
October 9, 2025 at 3:01 PM
Ready to start your own independent research programme?
We're inviting applications for early career group leaders in all areas of biology and biomedicine @crick.ac.uk
Apply by 27 Nov 2025:
www.crick.ac.uk/careers-stud...
#EarlyCareerResearchers #GroupLeader #ScienceCareers
We're inviting applications for early career group leaders in all areas of biology and biomedicine @crick.ac.uk
Apply by 27 Nov 2025:
www.crick.ac.uk/careers-stud...
#EarlyCareerResearchers #GroupLeader #ScienceCareers
Reposted by Mcclelland lab
We are looking for a senior technician (can undertake PhD) at Uni of Birmingham (UK) to study chromatin replication and ubiquitylation using Xenopus egg extract. Deadline 28/10/25. Get in touch with me or @m-saponaro.bsky.social for informal inquiries. Please share.
www.jobs.ac.uk/job/DOW912/s...
www.jobs.ac.uk/job/DOW912/s...
Senior Research Technician at University of Birmingham
Explore an exciting academic career as a Senior Research Technician. Don't miss out on other academic jobs. Click to apply and explore more opportunities.
www.jobs.ac.uk
October 7, 2025 at 8:51 AM
We are looking for a senior technician (can undertake PhD) at Uni of Birmingham (UK) to study chromatin replication and ubiquitylation using Xenopus egg extract. Deadline 28/10/25. Get in touch with me or @m-saponaro.bsky.social for informal inquiries. Please share.
www.jobs.ac.uk/job/DOW912/s...
www.jobs.ac.uk/job/DOW912/s...
Reposted by Mcclelland lab
3-year technician position with a possibility of doing a PhD available to study chromatin replication and ubiquitylation using cell free system of Xenopus laevis egg extract. Closing date 28/10/25. Get in touch @agagambus.bsky.social or @m-saponaro.bsky.social for informal inquiries
lnkd.in/etU3yydb
lnkd.in/etU3yydb
LinkedIn
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lnkd.in
October 7, 2025 at 8:52 AM
3-year technician position with a possibility of doing a PhD available to study chromatin replication and ubiquitylation using cell free system of Xenopus laevis egg extract. Closing date 28/10/25. Get in touch @agagambus.bsky.social or @m-saponaro.bsky.social for informal inquiries
lnkd.in/etU3yydb
lnkd.in/etU3yydb
Reposted by Mcclelland lab
Shortlisted candidates will be invited to give a seminar at the Fellows Conference, which will be held on 10 March 2026.
Candidates who win Fellowships will be offered a Tenure Track Group Leader position from the outset, initially for 5 years.
Find out more: www.jic.ac.uk/training-car...
Candidates who win Fellowships will be offered a Tenure Track Group Leader position from the outset, initially for 5 years.
Find out more: www.jic.ac.uk/training-car...
Independent Research Fellowships Leading to Tenured Faculty Positions | John Innes Centre
The John Innes Centre (JIC), is a world leading centre of excellence in plant and microbial sciences based on the Norwich Research Park, UK. We are inviting applications from outstanding researchers…
www.jic.ac.uk
October 3, 2025 at 3:12 PM
Shortlisted candidates will be invited to give a seminar at the Fellows Conference, which will be held on 10 March 2026.
Candidates who win Fellowships will be offered a Tenure Track Group Leader position from the outset, initially for 5 years.
Find out more: www.jic.ac.uk/training-car...
Candidates who win Fellowships will be offered a Tenure Track Group Leader position from the outset, initially for 5 years.
Find out more: www.jic.ac.uk/training-car...
Reposted by Mcclelland lab
Are you a future black leader in cancer? Come join @mirazrahman.bsky.social and my labs @qmbci.bsky.social @kingscollegelondon.bsky.social to work on turning defective cell cycle checkpoints into innovative cancer therapies! Get in touch for more details www.colcc.ac.uk/2026-blic-ph...
October 2, 2025 at 2:59 PM
Are you a future black leader in cancer? Come join @mirazrahman.bsky.social and my labs @qmbci.bsky.social @kingscollegelondon.bsky.social to work on turning defective cell cycle checkpoints into innovative cancer therapies! Get in touch for more details www.colcc.ac.uk/2026-blic-ph...
We are looking for our next PhD student to join us 🤩 www.mcclellandlab.com to understand cancer radiation therapy's impact on DNA damage repair and chromosomal instability. Prestigious funding from CRUK RadNet. Please contact me informally - deadline 5th Nov! crukradnet.colcc.ac.uk/phd-students...
October 2, 2025 at 3:49 PM
We are looking for our next PhD student to join us 🤩 www.mcclellandlab.com to understand cancer radiation therapy's impact on DNA damage repair and chromosomal instability. Prestigious funding from CRUK RadNet. Please contact me informally - deadline 5th Nov! crukradnet.colcc.ac.uk/phd-students...
Reposted by Mcclelland lab
Our first Centre for Cancer Evolution PI retreat! A wonderful day at Goodenough House discussing science, strategy and forging new collaborations @qmbci.bsky.social
October 1, 2025 at 12:00 PM
Our first Centre for Cancer Evolution PI retreat! A wonderful day at Goodenough House discussing science, strategy and forging new collaborations @qmbci.bsky.social
Reposted by Mcclelland lab
Last day of the @theaacr.bsky.social Advances in Pancreatic Cancer Research Conference in Boston!
Yesterday I presented my poster on genome evolution & chemoresistance in PDAC, from @mcclellandlab.bsky.social. Thanks for the great feedback — and to @pancreaticcanuk.bsky.social for the opportunity!
Yesterday I presented my poster on genome evolution & chemoresistance in PDAC, from @mcclellandlab.bsky.social. Thanks for the great feedback — and to @pancreaticcanuk.bsky.social for the opportunity!
October 1, 2025 at 12:46 PM
Last day of the @theaacr.bsky.social Advances in Pancreatic Cancer Research Conference in Boston!
Yesterday I presented my poster on genome evolution & chemoresistance in PDAC, from @mcclellandlab.bsky.social. Thanks for the great feedback — and to @pancreaticcanuk.bsky.social for the opportunity!
Yesterday I presented my poster on genome evolution & chemoresistance in PDAC, from @mcclellandlab.bsky.social. Thanks for the great feedback — and to @pancreaticcanuk.bsky.social for the opportunity!
Come and join us at the Barts Cancer Institute @qmbci.bsky.social ! Our medical school, part of Queen Mary University of London @qmulfmd.bsky.social is hiring 10 professors!! www.veredus.co.uk/job/job-747a/. Contact me for a chat if interested.
Professors x 10, Faculty of Medicine & Dentistry | Veredus
QUEEN MARY UNIVERSITY OF LONDON Professors x 10, Faculty of Medicine and Dentistry London Competitive Remuneration Package Queen Mary University of London seeks up to 10 world-leading translational re...
www.veredus.co.uk
October 1, 2025 at 7:34 AM
Come and join us at the Barts Cancer Institute @qmbci.bsky.social ! Our medical school, part of Queen Mary University of London @qmulfmd.bsky.social is hiring 10 professors!! www.veredus.co.uk/job/job-747a/. Contact me for a chat if interested.
Reposted by Mcclelland lab
Dosage responses of aneuploid autosomal chromosomes https://www.biorxiv.org/content/10.1101/2025.09.18.677044v1
September 20, 2025 at 9:30 PM
Dosage responses of aneuploid autosomal chromosomes https://www.biorxiv.org/content/10.1101/2025.09.18.677044v1
Reposted by Mcclelland lab
@mariasecrier.bsky.social & I are looking for an enthusiastic & excellent data scientist for a 4-year postdoc to understand cell cycle dysregulation in cancer.
Deadline 15th October. Get in touch if you have any questions.
Please repost!
More details:
www.imperial.ac.uk/jobs/search-...
Deadline 15th October. Get in touch if you have any questions.
Please repost!
More details:
www.imperial.ac.uk/jobs/search-...
Description
Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...
www.imperial.ac.uk
September 18, 2025 at 8:02 PM
@mariasecrier.bsky.social & I are looking for an enthusiastic & excellent data scientist for a 4-year postdoc to understand cell cycle dysregulation in cancer.
Deadline 15th October. Get in touch if you have any questions.
Please repost!
More details:
www.imperial.ac.uk/jobs/search-...
Deadline 15th October. Get in touch if you have any questions.
Please repost!
More details:
www.imperial.ac.uk/jobs/search-...
Please visit our newly refreshed and updated website mcclellandlab.com We seem to be hard to find on Google for some reason, any tips from website savvy people?? 🙏
September 18, 2025 at 7:24 AM
Please visit our newly refreshed and updated website mcclellandlab.com We seem to be hard to find on Google for some reason, any tips from website savvy people?? 🙏
Reposted by Mcclelland lab
Checkout our latest research in @natcomms.nature.com
rdcu.be/eBqBI A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells. A collaboration with Mike Boemo’s team
rdcu.be/eBqBI A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells. A collaboration with Mike Boemo’s team
A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells
Nature Communications - Determining how replication forks move across the human genome is critical for the effective use of agents that target replication stress. Here, the authors present...
rdcu.be
September 1, 2025 at 10:04 AM
Checkout our latest research in @natcomms.nature.com
rdcu.be/eBqBI A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells. A collaboration with Mike Boemo’s team
rdcu.be/eBqBI A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells. A collaboration with Mike Boemo’s team
Reposted by Mcclelland lab
Now out! Led by @susana-sousa.bsky.social and Noa Amin, and thanks to our collaborators in the Harrington @icr.ac.uk and Stucki and Choudhary @jc4-jyoti.bsky.social labs
www.cell.com/cell-reports...
www.cell.com/cell-reports...
September 16, 2025 at 3:30 PM
Now out! Led by @susana-sousa.bsky.social and Noa Amin, and thanks to our collaborators in the Harrington @icr.ac.uk and Stucki and Choudhary @jc4-jyoti.bsky.social labs
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Reposted by Mcclelland lab
Alex's highly complementary study and fantastic story here: www.nature.com/articles/s41...
Learning the cellular origins across cancers using single-cell chromatin landscapes - Nature Communications
Understanding the cellular origins of cancers is crucial for improving diagnosis and treatment. Here, the authors utilize single cell chromatin accessibility data, patient whole-genome sequencing muta...
www.nature.com
September 17, 2025 at 8:18 PM
Alex's highly complementary study and fantastic story here: www.nature.com/articles/s41...
The ‘surprise baby’ of papers, we trained visiting lecturer from Thailand 🇹🇭 Raksawan, who co-led by @nadeemshaikh.bsky.social and @mollyguscott.bsky.social produced our first work investigating CIN in Cholangiocarcinoma (prevalent in Northern🇹🇭 ). Congrats to co-corr author @nadeemshaikh.bsky.social!
@mcclellandlab.bsky.social hosted Prof Raksawan Deenonpoe from Thailand so she could collaborate with @mollyguscott.bsky.social & I to look for evidence of chromosomal instability in cholangiocarcinoma. Our work is now published in Journal of Pathology.
September 17, 2025 at 6:22 AM
The ‘surprise baby’ of papers, we trained visiting lecturer from Thailand 🇹🇭 Raksawan, who co-led by @nadeemshaikh.bsky.social and @mollyguscott.bsky.social produced our first work investigating CIN in Cholangiocarcinoma (prevalent in Northern🇹🇭 ). Congrats to co-corr author @nadeemshaikh.bsky.social!
Reposted by Mcclelland lab
🎉 Join us in congratulating four BCI researchers who have been promoted!
Promoted to Professor:
🔹Professor Angus Cameron
🔹Professor Jun Wang
Promoted to Senior Lecturer:
🔹Dr Diu Nguyen
Promoted to Reder:
🔹Dr Miguel Ganuza
@qmul.bsky.social @qmulfmd.bsky.social @cruk-cityoflondon.bsky.social
Promoted to Professor:
🔹Professor Angus Cameron
🔹Professor Jun Wang
Promoted to Senior Lecturer:
🔹Dr Diu Nguyen
Promoted to Reder:
🔹Dr Miguel Ganuza
@qmul.bsky.social @qmulfmd.bsky.social @cruk-cityoflondon.bsky.social
September 10, 2025 at 10:38 AM
🎉 Join us in congratulating four BCI researchers who have been promoted!
Promoted to Professor:
🔹Professor Angus Cameron
🔹Professor Jun Wang
Promoted to Senior Lecturer:
🔹Dr Diu Nguyen
Promoted to Reder:
🔹Dr Miguel Ganuza
@qmul.bsky.social @qmulfmd.bsky.social @cruk-cityoflondon.bsky.social
Promoted to Professor:
🔹Professor Angus Cameron
🔹Professor Jun Wang
Promoted to Senior Lecturer:
🔹Dr Diu Nguyen
Promoted to Reder:
🔹Dr Miguel Ganuza
@qmul.bsky.social @qmulfmd.bsky.social @cruk-cityoflondon.bsky.social
Exciting work from my colleague Ben @benjaminwerner.bsky.social and others!
📰Rogue DNA rings could provide early clues to brain cancer’s growth, according to new results co-led by Dr @benjaminwerner.bsky.social, as part of international @cancergrand.bsky.social collaboration
@qmul.bsky.social | @crick.ac.uk | @stanford.edu | @aacrjournals.bsky.social | #medsky #oncosky 🧪
@qmul.bsky.social | @crick.ac.uk | @stanford.edu | @aacrjournals.bsky.social | #medsky #oncosky 🧪
Rogue’ DNA rings reveal earliest clues to deadly brain cancer’s growth - Barts Cancer Institute - Queen Mary University of London
An international team of scientists has revealed how rogue rings of DNA that float outside of our chromosomes – known as extrachromosomal DNA, or ecDNA – can drive the growth of a large proportion of ...
www.bci.qmul.ac.uk
September 8, 2025 at 9:34 PM
Exciting work from my colleague Ben @benjaminwerner.bsky.social and others!
Calling all non-scientists interested in asking questions about cancer research for our new podcast-in-making!!! Please message your questions or contact me for more details 🤩
September 8, 2025 at 7:10 PM
Calling all non-scientists interested in asking questions about cancer research for our new podcast-in-making!!! Please message your questions or contact me for more details 🤩
Reposted by Mcclelland lab
Very happy to share our work on signature SBS5. See Molly's thread for a short summary
In these dark times, it comes as a rare pleasure to highlight @natanaels.bsky.social & @marcdemanuel.bsky.social's work on germline and somatic mutations in humans. 1/n
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
Collateral mutagenesis funnels multiple sources of DNA damage into a ubiquitous mutational signature
Mutations reflect the net effects of myriad types of damage, replication errors, and repair mechanisms, and thus are expected to differ across cell types with distinct exposures to mutagens, division ...
www.biorxiv.org
September 3, 2025 at 3:56 PM
Very happy to share our work on signature SBS5. See Molly's thread for a short summary
Reposted by Mcclelland lab
#1 Centromeres are epigenetic loci defined by CENP-A, positioned in unmethylated DNA flanked by highly methylated regions. Our work, published in @natgenet.nature.com in collaboration with @naltemose.bsky.social investigates the role of DNAme at human centromeres www.nature.com/articles/s41...
DNA methylation influences human centromere positioning and function - Nature Genetics
Genome-wide and targeted perturbation of DNA methylation at centromeres affects CENP-A positioning and centromere structure, resulting in aneuploidy and reduced cell viability.
www.nature.com
September 4, 2025 at 1:10 PM
#1 Centromeres are epigenetic loci defined by CENP-A, positioned in unmethylated DNA flanked by highly methylated regions. Our work, published in @natgenet.nature.com in collaboration with @naltemose.bsky.social investigates the role of DNAme at human centromeres www.nature.com/articles/s41...
Reposted by Mcclelland lab
My first post on bsky to share our latest research in @nature.com: “DNA2 enables growth by restricting recombination-restarted replication” - defines DNA2’s essential function & elucidates links with primordial dwarfism and cancer. Thanks to the lab, collaborators & @ukri.org @acmedsci.bsky.social
DNA2 enables growth by restricting recombination-restarted replication - Nature
DNA2 suppresses recombination-restarted replication and checkpoint activation at stalled forks, and its loss triggers recombination-dependent synthesis, checkpoint signalling and cell-cycle exit, high...
www.nature.com
September 3, 2025 at 3:59 PM
My first post on bsky to share our latest research in @nature.com: “DNA2 enables growth by restricting recombination-restarted replication” - defines DNA2’s essential function & elucidates links with primordial dwarfism and cancer. Thanks to the lab, collaborators & @ukri.org @acmedsci.bsky.social
Reposted by Mcclelland lab
Narozna et al @gorbskylab.bsky.social uncover a high-frequency, chromosome 12-specific mis-segregation error in iPSCs. Eroded 12p arms lead to bridging & micronucleation, enabling widespread trisomy 12. A slight growth advantage allows trisomic cells to persist & dominate rupress.org/jcb/article/...
August 13, 2025 at 5:15 PM
Narozna et al @gorbskylab.bsky.social uncover a high-frequency, chromosome 12-specific mis-segregation error in iPSCs. Eroded 12p arms lead to bridging & micronucleation, enabling widespread trisomy 12. A slight growth advantage allows trisomic cells to persist & dominate rupress.org/jcb/article/...
Reposted by Mcclelland lab
