Matt Rich
@mattrich.bsky.social
Geneticist in Erik Jorgensen's lab @UUtah. Trying to turn worms into yeast. Also neuron maturation and giant ankyrin. PhD with Stan Fields @uwgenome. Princeton ‘09. (he/him)
New preprint!
It turns out you can integrate arrays with super high efficiency using PhiC31.
www.biorxiv.org/content/10.1...
It turns out you can integrate arrays with super high efficiency using PhiC31.
www.biorxiv.org/content/10.1...
High-efficiency targeted integration of extrachromosomal arrays in C. elegans using PhiC31 integrase
Extrachromosomal arrays are unique chromosome-like structures created from DNA injected into the C. elegans germline. Arrays are easy to create and allow for high expression of multiple transgenes. Th...
www.biorxiv.org
November 13, 2025 at 2:59 AM
New preprint!
It turns out you can integrate arrays with super high efficiency using PhiC31.
www.biorxiv.org/content/10.1...
It turns out you can integrate arrays with super high efficiency using PhiC31.
www.biorxiv.org/content/10.1...
Will Scharf in the server room with a sledgehammer
WHITE HOUSE: FEDERAL STATISTICAL SYSTEM MAY HAVE PERMANENTLY BEEN DAMAGED WHITE HOUSE: OCTOBER JOBS REPORTS LIKELY NEVER RELEASED
November 12, 2025 at 8:02 PM
Will Scharf in the server room with a sledgehammer
Let’s send a socialist to Congress!
‘Extreme’ gerrymander: Utah judge rejects GOP lawmakers’ congressional map, picks districts favoring Democrats
A Utah judge rejected new congressional boundaries proposed by Republican lawmakers, instead choosing a map that will create a heavily Democratic-leaning district in Salt Lake County.
www.sltrib.com
November 11, 2025 at 2:03 PM
Let’s send a socialist to Congress!
Reposted by Matt Rich
3 years ago Elon enabled the funniest day in Twitter history.
November 10, 2025 at 8:05 PM
3 years ago Elon enabled the funniest day in Twitter history.
Reposted by Matt Rich
It should be illegal to be this stupid
Shaheen: "We've heard from a number of our colleagues on the other side of the aisle that they're willing to come to the table, they're willing to work with us once the govt is open to get this done. We've heard the same thing from the White House. So now we'll see if they're really gonna work w/us"
November 10, 2025 at 3:39 PM
It should be illegal to be this stupid
Reposted by Matt Rich
On Friday, Mick Fleetwood surprised fans by playing “Tusk” with the Trojan Marching Band. But Dr. Bartner, the 85-year-old band director who helped bring it to life and earned USC two platinum, albums also surprised Mick. Inside the very L.A. story of the iconic “Tusk.”
www.espn.com/college-foot...
www.espn.com/college-foot...
'It's our tune': How Fleetwood Mac worked with the USC Marching Band to create 'Tusk'
The idea initially sounded so far-fetched band directors thought it was a prank. But the collaboration became a sensation.
www.espn.com
November 10, 2025 at 1:14 PM
On Friday, Mick Fleetwood surprised fans by playing “Tusk” with the Trojan Marching Band. But Dr. Bartner, the 85-year-old band director who helped bring it to life and earned USC two platinum, albums also surprised Mick. Inside the very L.A. story of the iconic “Tusk.”
www.espn.com/college-foot...
www.espn.com/college-foot...
Reposted by Matt Rich
When the president gets ordered, multiple times, to pay out federal food benefits as the law requires:
November 8, 2025 at 12:39 AM
When the president gets ordered, multiple times, to pay out federal food benefits as the law requires:
Reposted by Matt Rich
KOKO: Chatgpt, good chatgpt, vibe code app
ME: No Koko the app doesn't work, it won't function
KOKO: Gorilla code, gorilla engineer
ME: Koko the app doesn't even load on mobile
KOKO: jealousy cynic
ME: No Koko the app doesn't work, it won't function
KOKO: Gorilla code, gorilla engineer
ME: Koko the app doesn't even load on mobile
KOKO: jealousy cynic
November 7, 2025 at 3:23 PM
KOKO: Chatgpt, good chatgpt, vibe code app
ME: No Koko the app doesn't work, it won't function
KOKO: Gorilla code, gorilla engineer
ME: Koko the app doesn't even load on mobile
KOKO: jealousy cynic
ME: No Koko the app doesn't work, it won't function
KOKO: Gorilla code, gorilla engineer
ME: Koko the app doesn't even load on mobile
KOKO: jealousy cynic
Reposted by Matt Rich
I didn't even *want* to lean on the barrier until I saw this cool guy doing it
November 6, 2025 at 5:59 PM
I didn't even *want* to lean on the barrier until I saw this cool guy doing it
why anyone thinks it’s a good idea to torment your readers with images of douthat is beyond me
LOL, naturally the NYTimes, engaging in just the most open self-parody, has a big homepage video for Ross Douthat "Mamdani's victory is less significant than you think" so you have to scroll down to see anything else, because they have to be sullen and bitter about it.
November 6, 2025 at 2:32 PM
why anyone thinks it’s a good idea to torment your readers with images of douthat is beyond me
Oh you mean this guy hates NY?
November 5, 2025 at 7:25 PM
Oh you mean this guy hates NY?
November 5, 2025 at 3:16 PM
Reposted by Matt Rich
came across this with no context but you know what, sure okay
in short:
if you're looking for love, get your nuts out by the fire.
if you're looking for love, get your nuts out by the fire.
November 5, 2025 at 2:33 PM
came across this with no context but you know what, sure okay
Reposted by Matt Rich
it is the marshawn lynch approach to politics
November 5, 2025 at 1:40 AM
it is the marshawn lynch approach to politics
Reposted by Matt Rich
This is so much goddamn work!!
They made... an AI tool... to make AI... which is already built on actual writing... seem less like slop...
JUST DO THE WRITING YOURSELF TO BEGIN WITH JESUS FUCKING CHRIST
JUST DO THE WRITING YOURSELF TO BEGIN WITH JESUS FUCKING CHRIST
November 4, 2025 at 2:30 AM
This is so much goddamn work!!
“we polled 9 people outside the ny post office and one said they would leave if mamdani were elected…”
Nearly a million New Yorkers ready to flee NYC if Mamdani becomes mayor — possibly igniting mass exodus: poll
Nearly a million New Yorkers ready to flee NYC if Mamdani becomes mayor — possibly igniting mass exodus: poll
Hundreds of thousands of New Yorkers are prepared to bolt from the Big Apple if socialist candidate Zohran Mamdani wins Tuesday's mayoral race — potentially setting the stage for the largest population flight in US history, a new poll warns.
nypost.com
November 3, 2025 at 2:23 PM
“we polled 9 people outside the ny post office and one said they would leave if mamdani were elected…”
my god
November 2, 2025 at 12:22 AM
my god
Reposted by Matt Rich
“They were careless people, Tom and Daisy—they smashed up things and creatures and then retreated back into their money or their vast carelessness or whatever it was that kept them together, and let other people clean up the mess...”
Per Danny Kemp via press pool
Trump is at the Halloween party at MAL
“Official theme is Gatsby and ‘a little party never killed nobody’, we’re told.”
Trump is at the Halloween party at MAL
“Official theme is Gatsby and ‘a little party never killed nobody’, we’re told.”
November 1, 2025 at 3:09 AM
“They were careless people, Tom and Daisy—they smashed up things and creatures and then retreated back into their money or their vast carelessness or whatever it was that kept them together, and let other people clean up the mess...”
Submitted a job application. Gonna throw up lol.
October 30, 2025 at 3:56 PM
Submitted a job application. Gonna throw up lol.
Reposted by Matt Rich
I use Claude (an AI) to scan my posts for spelling and grammar errors. On the most recent post (about the East Wing, link below), I got a really amazing addendum.
www.pbump.net/o/yes-most-a...
www.pbump.net/o/yes-most-a...
October 30, 2025 at 3:03 PM
I use Claude (an AI) to scan my posts for spelling and grammar errors. On the most recent post (about the East Wing, link below), I got a really amazing addendum.
www.pbump.net/o/yes-most-a...
www.pbump.net/o/yes-most-a...
or you could be nice, go over for the bbq, and get your tastebuds lit up in ways you’ve never experienced before
Vance says it is "totally reasonable and acceptable" for people to not want to live next door to people who speak a different language than they do
October 29, 2025 at 6:37 PM
or you could be nice, go over for the bbq, and get your tastebuds lit up in ways you’ve never experienced before
Reposted by Matt Rich
I know it’s too much to expect them to know their history, but if the American Revolution had a motto, it definitely would not have been “immigrants go home.”
It would have been “get your fucking soldiers out of our cities.”
It would have been “get your fucking soldiers out of our cities.”
October 28, 2025 at 1:48 PM
I know it’s too much to expect them to know their history, but if the American Revolution had a motto, it definitely would not have been “immigrants go home.”
It would have been “get your fucking soldiers out of our cities.”
It would have been “get your fucking soldiers out of our cities.”
Reposted by Matt Rich
i really resent the continued assertion that there’s so much anger on both sides, as if the causes of the anger are equally legitimate. we’re angry because masked maniacs are violently snatching our family and neighbors off the street, and they’re angry because we’re calling them out for it.
October 25, 2025 at 5:57 PM
i really resent the continued assertion that there’s so much anger on both sides, as if the causes of the anger are equally legitimate. we’re angry because masked maniacs are violently snatching our family and neighbors off the street, and they’re angry because we’re calling them out for it.
All the boys these days have mustaches.
Are beards out? Don’t their cheeks get cold?
Are beards out? Don’t their cheeks get cold?
October 24, 2025 at 3:33 PM
All the boys these days have mustaches.
Are beards out? Don’t their cheeks get cold?
Are beards out? Don’t their cheeks get cold?