Authors 𝗺𝗮𝗽𝗽𝗲𝗱 𝘁𝗵𝗲 𝗻𝗮𝗻𝗼𝘀𝗰𝗮𝗹𝗲 𝟯𝗗 𝗼𝗿𝗴𝗮𝗻𝗶𝘇𝗮𝘁𝗶𝗼𝗻 𝗼𝗳 𝘁𝗵𝗲 𝗽𝗿𝗲𝘀𝘆𝗻𝗮𝗽𝘁𝗶𝗰 𝗮𝗰𝘁𝗶𝘃𝗲 𝘇𝗼𝗻𝗲 and revealed that the C-terminus of the scaffolding protein bassoon is oriented toward the synaptic cleft, while its N-terminus extends toward synaptic vesicles.

Fantastic work by Florelle Domart, Evelyn Garlick, Isabelle Jansen, Maria Augusta Lima, & Thomas Dresbach!

We’re thrilled to report 𝗮𝘂𝘁𝗵𝗼𝗿𝘀 𝘂𝘀𝗲𝗱 𝗼𝘂𝗿 𝗮𝗻𝘁𝗶-𝗿𝗮𝗯𝗯𝗶𝘁, 𝗮𝗻𝘁𝗶-𝗺𝗼𝘂𝘀𝗲, 𝗮𝗻𝘁𝗶-𝗚𝗙𝗣, 𝗮𝗻𝗱 𝗮𝗻𝘁𝗶-𝗔𝗟𝗙𝗔 𝘁𝗮𝗴 𝗗𝗡𝗔-𝗣𝗔𝗜𝗡𝗧 𝗸𝗶𝘁𝘀 𝗳𝗼𝗿 𝗶𝗺𝗮𝗴𝗶𝗻𝗴!

Why our DNA-PAINT Halo Kits?
✔️ Ultra-precise labeling with small single-domain antibodies (~15 kDa)
✔️ Full compatibility with the Halo system - no interference with Halo-ligand binding
✔️ Unmatched resolution with DNA-PAINT (10–20 nm)
✔️ Seamless integration into existing super-resolution workflows

⭐ Anti-Halo single-domain antibodies licensed from @nanotag.bsky.social, where they’re available unmodified and fluorophore-coupled.

🧬 Curious about starting DNA-PAINT super-resolution microscopy? Reach out: info@massive-photonics.com

💡 𝗣𝗿𝗼 𝗧𝗶𝗽: For maximum resolution use imager dye 𝗖𝘆𝟯𝗕.

Speed or resolution: which will drive your next discovery?

𝗦𝘁𝗮𝗻𝗱𝗮𝗿𝗱 𝘀𝗲𝗾𝘂𝗲𝗻𝗰𝗲𝘀 (in DNA-PAINT Kits)
🔹 Resolution: ~20 nm
🔹 Imaging time: 30–60 min/target
🔹 Exposure: 150–250 ms
👉 Compatible with 𝗠𝗜𝗡𝗙𝗟𝗨𝗫 𝗗𝗡𝗔-𝗣𝗔𝗜𝗡𝗧

𝗙𝗔𝗦𝗧-𝗟𝗕 𝘀𝗲𝗾𝘂𝗲𝗻𝗰𝗲𝘀 (option in FAST Kits)
🔹 Resolution: ~10 nm
🔹 Imaging time: 10–30 min/target
🔹 Exposure: 100–150 ms
👉 Best for 𝗵𝗶𝗴𝗵𝗲𝘀𝘁 𝗿𝗲𝘀𝗼𝗹𝘂𝘁𝗶𝗼𝗻
👉 Compatible with 𝗠𝗜𝗡𝗙𝗟𝗨𝗫 𝗗𝗡𝗔-𝗣𝗔𝗜𝗡𝗧

𝗙𝗔𝗦𝗧 𝘀𝗲𝗾𝘂𝗲𝗻𝗰𝗲𝘀 (option in FAST Kits)
🔹 Resolution: ~15 nm
🔹 Imaging time: 5–15 min/target
🔹 Exposure: 30–75 ms
👉 Best for 𝗳𝗮𝘀𝘁𝗲𝗿 𝗶𝗺𝗮𝗴𝗶𝗻𝗴

💡 𝗣𝗿𝗼 𝗧𝗶𝗽: For maximum resolution use imager dye 𝗖𝘆𝟯𝗕.

Speed or resolution: which will drive your next discovery?

✨ 𝗦𝘁𝗮𝗻𝗱𝗮𝗿𝗱 𝘀𝗲𝗾𝘂𝗲𝗻𝗰𝗲𝘀 (in DNA-PAINT Kits)
🔹 Resolution: ~20 nm
🔹 Imaging time: 30–60 min/target
🔹 Exposure: 150–250 ms
👉 Compatible with 𝗠𝗜𝗡𝗙𝗟𝗨𝗫 𝗗𝗡𝗔-𝗣𝗔𝗜𝗡𝗧

✨ 𝗙𝗔𝗦𝗧-𝗟𝗕 𝘀𝗲𝗾𝘂𝗲𝗻𝗰𝗲𝘀 (option in FAST Kits)
🔹 Resolution: ~10 nm
🔹 Imaging time: 10–30 min/target
🔹 Exposure: 100–150 ms
👉 Best for 𝗵𝗶𝗴𝗵𝗲𝘀𝘁 𝗿𝗲𝘀𝗼𝗹𝘂𝘁𝗶𝗼𝗻
👉 Compatible with 𝗠𝗜𝗡𝗙𝗟𝗨𝗫 𝗗𝗡𝗔-𝗣𝗔𝗜𝗡𝗧

✨ 𝗙𝗔𝗦𝗧 𝘀𝗲𝗾𝘂𝗲𝗻𝗰𝗲𝘀 (option in FAST Kits)
🔹 Resolution: ~15 nm
🔹 Imaging time: 5–15 min/target
🔹 Exposure: 30–75 ms
👉 Best for 𝗳𝗮𝘀𝘁𝗲𝗿 𝗶𝗺𝗮𝗴𝗶𝗻𝗴

🤔 Not sure where to start? Email us at info@massive-photonics.com

anti-ALFA single-domain antibodies licensed from @nanotag.bsky.social where it's available unmodified and fluorophore-coupled

The 𝗔𝗟𝗙𝗔-𝘁𝗮𝗴 𝗶𝘀 𝗮 𝘀𝗺𝗮𝗹𝗹 𝗿𝗮𝘁𝗶𝗼𝗻𝗮𝗹𝗹𝘆 𝗱𝗲𝘀𝗶𝗴𝗻𝗲𝗱 𝗽𝗿𝗼𝘁𝗲𝗶𝗻 𝘁𝗮𝗴 that facilitates highly specific labeling when combined with the anti-ALFA single-domain antibody (rdcu.be/eFy86 ).

𝗥𝗘𝗦𝗜 𝗶𝘀 𝗮 𝗗𝗡𝗔-𝗣𝗔𝗜𝗡𝗧 𝗯𝗮𝘀𝗲𝗱 𝗺𝗲𝘁𝗵𝗼𝗱 that achieves sub-nanometer spatial-resolution in cells, enabling precise imaging of individual proteins (rdcu.be/eFy7c).

🔬 𝗢𝘂𝗿 𝗥𝗘𝗦𝗜 𝗞𝗶𝘁𝘀 𝗱𝗲𝗹𝗶𝘃𝗲𝗿:
✔️ Single-protein resolution even in dense formations like dimers and clusters
✔️ Full field-of-view imaging for robust statistics and whole-cell investigations
✔️ Compatibility with widefield-TIRF and commercial SMLM microscopes

Start revealing cellular structures with nanoscale precision today!

#SMLM #Microscopy #DNAPAINT #MassivePhotonics

🔬 DNA-PAINT is compatible with widefield-TIRF and commercial SMLM microscopes
💻 Analyze your data with SMLM software or the open-source Picasso toolkit (www.biochem.mpg.de/jungmann/sof...)

👉 www.massive-photonics.com/technology/