14/ Big thanks also to the institutions that provided tumor samples @dukepress.bsky.social, @mdanderson.bsky.social, Tokyo University Hospital, Pitié-Salpêtrière Hospital, St. Michael's Hospital, Seoul National University and NORLUX and funders NIH, NCI, Mark Foundation and Sontag Foundation.

13/ @weizmanninstitute.bsky.social, Mass General Brigham (Cancer Center, Pathology), @broadinstitute.org, @yalepress.bsky.social and University of Miami.

12/ Big thanks to the PIs that supervised the project @itaytirosh.bsky.social, @suvalab.bsky.social, @roelverhaak.bsky.social, Antonio Iavarone and Anna Lasorella, all collaborators and institutions involved in the CARE consortium >

4/ And now for the results! Across the cohort the most consistent change at recurrence was reduced malignant cell fraction, with a reciprocal increase in glial and neuronal TME cells. This was observed in ~66% of patients, suggesting increased tumor integration into brain tissue.

3/ We first leveraged this large cohort to revisit the intra- and inter-tumor heterogeneity in GBM and characterized three multi-layered transcriptional ecosystems. Read more about this study in this great thread by @masashi-nomura.bsky.social →

bsky.app/profile/masa...

1/ Truly excited to share our new study that I had to privilege to co-lead during my PhD alongside great friends and collaborators @masashi-nomura.bsky.social, @kevin-johnson.bsky.social and Luciano Garofano, published at Nature Genetics @natureportfolio.nature.com!

www.nature.com/articles/s41...

1/ Thrilled to share our TWO back-to-back papers published in Nature Genetics today! www.nature.com/articles/s41... , www.nature.com/articles/s41...